公开(公告)号：US5664686A

公开(公告)日：1997-09-09

申请号：US662065

申请日：1996-06-12

申请人： Yasunobu Hosogoshi ,  Toshio Maruo ,  Yasuo Sakata ,  Katsumasa Morita ,  Takefumi Ibori ,  Harumi Kubota ,  Toshio Douzono ,  Kanemitsu Nakagawa ,  Kunio Sugihara ,  Yukio Yoshizawa ,  Yoshiaki Aridome ,  Shoji Yamanaka

发明人： Yasunobu Hosogoshi ,  Toshio Maruo ,  Yasuo Sakata ,  Katsumasa Morita ,  Takefumi Ibori ,  Harumi Kubota ,  Toshio Douzono ,  Kanemitsu Nakagawa ,  Kunio Sugihara ,  Yukio Yoshizawa ,  Yoshiaki Aridome ,  Shoji Yamanaka

IPC分类号： B07B1/38 ,  B07B1/46 ,  B07B1/49

CPC分类号： B07B1/4618 ,  B07B1/38 ,  B07B1/46

摘要： A sifter frame is composed of a pair of frame elements including an outer frame and an inner frame, and the outer frame is formed from a frame member having the same height and includes a pair of fine powder dropping ports, a rough powder dropping port and a rectangular fine powder receiving plate disposed in a region surrounded by these openings and one of the outer block frame members and the inner frame is fitted with the space above the receiving plate. A pair of the outer frame members of the inner frame in contact with the fine powder dropping ports of the inner frame are projected more to the rough powder dropping port than the outer block frame members of the inner frame in contact with the rough powder dropping port of the outer frame, receiving portions are provided with the outer frame in correspondence with the above arrangement so that the projected portions of the inner frame are placed thereon as well as the surfaces where the projected portions are engaged with the receiving portions are formed to an arc shape in order to that a depressing force of an upper stage sifter frame is applied to the engaging surfaces where the inner frame of a lower stage sifter frame is engaged with the outer frame thereof as a sealing force. With the above arrangement, there is provided a novel stacking type sifter frame by which the mixture of rough powder with fine powder can be securely prevented while limiting a portion to be periodically replaced to a minimum necessary portion.

摘要翻译： 筛子框架由包括外框架和内框架的一对框架元件构成，外框架由具有相同高度的框架构件形成，并且包括一对细粉末滴入口，粗粉末滴入口和 设置在由这些开口包围的区域中的矩形细粉末容纳板和外块体框架构件和内框架中的一个嵌合有容纳板上方的空间。 与内部框架的细粉末滴下口接触的内框架的一对外框架构件比与内部框架的外部框架构件相比突出地更多地与粗粉末滴落口 外框架的接收部分设置有与上述布置相对应的外框架，使得内框架的突出部分被放置在其上，并且突出部分与接收部分接合的表面形成为 为了使下级筛子框架的内框架与其外框架接合的接合表面施加上级筛分框架的压下力作为密封力。 通过上述结构，提供了一种新颖的堆叠式筛子框架，通过该框架可以可靠地防止粗粉末与细粉末的混合，同时将要定期更换的部分限制在最小必需部分。

公开(公告)号：US4605555A

公开(公告)日：1986-08-12

申请号：US652465

申请日：1984-09-20

申请人： Mitsunobu Sato ,  Yasuhiro Katsuragi ,  Yasuo Sakano ,  Kunio Sugihara ,  Kenji Aimoto

发明人： Mitsunobu Sato ,  Yasuhiro Katsuragi ,  Yasuo Sakano ,  Kunio Sugihara ,  Kenji Aimoto

IPC分类号： A61K38/21 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K45/02

CPC分类号： A61K47/20 ,  A61K38/21 ,  A61K47/10 ,  A61K47/26 ,  A61K9/0014

摘要： A pharmaceutical composition for treating keratosic disorders of skin and mucosa, particularly, lichen planus and leukoplakia, by topical or local administration which comprises an effective amount of human interferon, a trihydric or more higher polyhydric sugar alcohol, an organic acid buffer and, optionally, an anionic surfactant and albumin, and a conventional pharmaceutical carrier or diluent. A method for treating a human subject suffering from keratosic disorders of skin and mucosa by using this composition is also provided.

摘要翻译： 一种用于通过局部或局部施用治疗皮肤和粘膜特别是扁平苔藓和白斑病的角质病症的药物组合物，其包含有效量的人干扰素，三元或更多元多羟基糖醇，有机酸缓冲液和任选地， 阴离子表面活性剂和白蛋白，以及常规药物载体或稀释剂。 还提供了通过使用该组合物治疗患有皮肤和粘膜角化病症的人类受试者的方法。

公开(公告)号：US5598931A

公开(公告)日：1997-02-04

申请号：US335578

申请日：1994-11-07

申请人： Yasunobu Hosogoshi ,  Toshio Maruo ,  Yasuo Sakata ,  Katsumasa Morita ,  Takefumi Ibori ,  Harumi Kubota ,  Toshio Douzono ,  Kanemitsu Nakagawa ,  Kunio Sugihara ,  Yukio Yoshizawa ,  Yoshiaki Aridome ,  Shoji Yamanaka

发明人： Yasunobu Hosogoshi ,  Toshio Maruo ,  Yasuo Sakata ,  Katsumasa Morita ,  Takefumi Ibori ,  Harumi Kubota ,  Toshio Douzono ,  Kanemitsu Nakagawa ,  Kunio Sugihara ,  Yukio Yoshizawa ,  Yoshiaki Aridome ,  Shoji Yamanaka

IPC分类号： B07B1/38 ,  B07B1/46 ,  B07B1/49

CPC分类号： B07B1/4618 ,  B07B1/38 ,  B07B1/46

摘要： A sifter frame is composed of a pair of frame elements including an outer frame and an inner frame, and the outer frame is formed from a frame member having the same height and includes a pair of fine powder dropping ports, a rough powder dropping port and a rectangular fine powder receiving plate disposed in a region surrounded by these openings and one of the outer block frame members and the inner frame is fitted with the space above the receiving plate. A pair of the outer frame members of the inner frame in contact with the fine powder dropping ports of the inner frame are projected more to the rough powder dropping port than the outer block frame members of the inner frame in contact with the rough powder dropping port of the outer frame, receiving portions are provided with the outer frame in correspondence with the above arrangement so that the projected portions of the inner frame are placed thereon as well as the surfaces where the projected portions are engaged with the receiving portions are formed to an arc shape in order to that a depressing force of an upper stage sifter frame is applied to the engaging surfaces where the inner frame of a lower stage sifter frame is engaged with the outer frame thereof as a sealing force. With the above arrangement, there is provided a novel stacking type sifter frame by which the mixture of rough powder with fine powder can be securely prevented while limiting a portion to be periodicially replaced to a minimum necessary portion.

摘要翻译： 筛子框架由包括外框架和内框架的一对框架元件构成，外框架由具有相同高度的框架构件形成，并且包括一对细粉末滴入口，粗粉末滴入口和 设置在由这些开口包围的区域中的矩形细粉末容纳板和外块体框架构件和内框架中的一个嵌合有容纳板上方的空间。 与内部框架的细粉末滴下口接触的内框架的一对外框架构件比与内部框架的外部框架构件相比突出地更多地与粗粉末滴落口 外框架的接收部分设置有与上述布置相对应的外框架，使得内框架的突出部分被放置在其上，并且突出部分与接收部分接合的表面形成为 为了使下级筛子框架的内框架与其外框架接合的接合表面施加上级筛分框架的压下力作为密封力。 通过上述布置，提供了一种新颖的堆叠式筛子框架，通过该框架可以可靠地防止粗粉末与细粉末的混合物，同时将要周期性更换的部分限制在最小必需部分。

公开(公告)号：US4605556A

公开(公告)日：1986-08-12

申请号：US652466

申请日：1984-09-20

申请人： Mitsunobu Sato ,  Yasuhiro Katsuragi ,  Yasuo Sakano ,  Kunio Sugihara ,  Kenji Aimoto

发明人： Mitsunobu Sato ,  Yasuhiro Katsuragi ,  Yasuo Sakano ,  Kunio Sugihara ,  Kenji Aimoto

IPC分类号： A61K38/21 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/26 ,  A61P17/00 ,  A61P37/00 ,  A61K45/02

CPC分类号： A61K38/21 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K9/0014

摘要： A pharmaceutical composition for treating erythematodes, particularly, lupus erythematodes discoides, or mycosis, particularly, candidasis, by topical or local administration which comprises an effective amount of human interferon, a trihydric or more higher polyhydric sugar alcohol, an organic acid buffer and, optionally, an anionic surfactant and albumin, and a conventional pharmaceutical carrier or diluent. A method for treating a human subject suffering from erythematodes and mycosis by using this composition is also provided.

摘要翻译： 一种用于通过局部或局部给药治疗红斑病，特别是红斑狼疮，真菌病，特别是念珠菌病的药物组合物，其包含有效量的人干扰素，三元以上更高级的多羟基糖醇，有机酸缓冲液和 ，阴离子表面活性剂和白蛋白，以及常规的药物载体或稀释剂。 还提供了通过使用该组合物治疗患有红斑和真菌病的人受试者的方法。

公开(公告)号：US4675184A

公开(公告)日：1987-06-23

申请号：US568033

申请日：1984-01-04

申请人： Kenji Hasegawa ,  Yasuo Sakano ,  Yasuhiro Katsuragi ,  Kenji Aimoto ,  Kunio Sugihara

发明人： Kenji Hasegawa ,  Yasuo Sakano ,  Yasuhiro Katsuragi ,  Kenji Aimoto ,  Kunio Sugihara

IPC分类号： A61K9/00 ,  A61K38/21 ,  A61K47/26 ,  A61K45/02

CPC分类号： A61K47/26 ,  A61K38/21 ,  A61K9/0014 ,  Y10S435/811

摘要： A pharmaceutical composition for treating viral diseases, such as pasta, gargle, gel, ointment, suppository, spray, etc., containing interferon in a stable state which comprises an effective amount of human interferon, 15 to 60% by weight of a tri or higher polyhydric sugar alcohol and an organic acid buffer as stabilizers, and a conventional pharmaceutical carrier or diluent. The pH of the composition is about 3 to 6. Optionally, the composition can further contain as a stabilizer an anionic surfactant and/or albumin.

摘要翻译： 一种用于治疗含有稳定状态的干扰素的病毒性疾病如面食，漱口剂，凝胶剂，软膏剂，栓剂，喷雾剂等的药物组合物，其包含有效量的人类干扰素，15至60重量％的三 高级多元糖醇和作为稳定剂的有机酸缓冲液，以及常规的药物载体或稀释剂。 组合物的pH为约3至6.任选地，组合物还可以含有阴离子表面活性剂和/或白蛋白作为稳定剂。

公开(公告)号：US06173477B1

公开(公告)日：2001-01-16

申请号：US09242322

申请日：1999-02-16

申请人： Takeshi Kikutani ,  Satoru Kondo ,  Shunichi Hayashi ,  Kunio Sugihara ,  Teruko Haguri ,  Kouhei Akimoto

发明人： Takeshi Kikutani ,  Satoru Kondo ,  Shunichi Hayashi ,  Kunio Sugihara ,  Teruko Haguri ,  Kouhei Akimoto

IPC分类号： A45C1322

CPC分类号： A46B5/02 ,  A46B2200/1066 ,  Y10T16/469 ,  Y10T16/498 ,  Y10T16/513 ,  Y10T16/516

摘要： A grip member has a grip proper (1) made of a shape-memory resin in the shape of a bar, a connecting pin (4) disposed in one terminal part of the grip proper, a forked part (3) formed integrally in the other terminal side of the grip proper, and an annular part (2) formed integrally slightly toward one end of the grip proper (1) and adapted for enabling the forked part (3) to twine thereon. The grip member is enabled to cope easily with a delicate change in the gripping condition by heating the grip proper (1) and the vicinity thereof to a temperature surpassing the glass transition point of the shape-memory resin thereby endowing the shape-memory rubber with a rubbery state, causing the forked part (3) to twine itself around the annular part (2) in such a manner as to impart the shape of a loop to the grip proper.

摘要翻译： 夹持构件具有由棒状的形状记忆树脂制成的抓握件（1），设置在把手本体的一个端子部分中的连接销（4），一体形成在所述夹持部件 所述手柄本体的另一个端部侧，以及环形部分（2），其一体地稍微地形成在所述把手本体（1）的一端上，并且适于使所述叉形部分（3）在其上缠绕。 通过将把手本身（1）及其附近加热至超过形状记忆树脂的玻璃化转变温度的温度，能够通过将握持状态的微妙变化容易地处理抓握构件，从而赋予形状记忆橡胶以赋予形状记忆橡胶 橡胶状态，使得叉形部分（3）绕环形部分（2）绕其自身缠绕，以便将环形形状赋予手柄本体。