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公开(公告)号：US20140364477A1
公开(公告)日：2014-12-11
申请号：US14468408
申请日：2014-08-26
申请人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
发明人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
IPC分类号： C07D209/08 , C07D209/30 , C07D209/18
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/30 , C07D209/40
摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
摘要翻译： 式（I）的吲哚基或二氢吲哚基化合物：其中键，n，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 还公开了用这些化合物治疗癌症的方法。
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公开(公告)号：US20110245315A1
公开(公告)日：2011-10-06
申请号：US13074312
申请日：2011-03-29
申请人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
发明人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
IPC分类号： A61K31/4045 , C07D209/08 , A61P35/00
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/30 , C07D209/40
摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
摘要翻译： 式（I）的吲哚基或二氢吲哚基化合物：其中键，n，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 还公开了用这些化合物治疗癌症的方法。
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3.发明授权Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury 有权吲哚基和二氢吲哚基异肟酸盐用于治疗神经元损伤的心力衰竭公开(公告)号：US09296692B2
公开(公告)日：2016-03-29
申请号：US14345246
申请日：2012-09-15
申请人： Yi-Jen Chen , Kuo-Sheng Hung , Yu-Hsun Kao , Jing-Ping Liou , Pei-Wen Shan
发明人： Yi-Jen Chen , Kuo-Sheng Hung , Yu-Hsun Kao , Jing-Ping Liou , Pei-Wen Shan
IPC分类号： C07D209/30 , C07D209/08 , C07D209/18 , A61K31/404
CPC分类号： C07D209/30 , A61K31/404 , C07D209/08 , C07D209/18
摘要： Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.
摘要翻译： 本文公开了小分子，特别是吲哚基和二氢吲哚基异肟酸盐的新用途。 吲哚基和二氢吲哚基异羟肟酸盐可用作制备用于治疗患有心力衰竭或神经元损伤的患者的药物或药物组合物的铅化合物。
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4.发明申请Use of Indolyl and Indolinyl Hydroxamates for Treating Heart Failure of Neuronal Injury 有权吲哚基和二氢吲哚基羟基化合物用于治疗神经损伤心力衰竭的应用公开(公告)号：US20150065552A1
公开(公告)日：2015-03-05
申请号：US14345246
申请日：2012-09-15
申请人： Yi-Jen Chen , Kuo-Sheng Hung , Yu-Hsun Kao , Jing-Ping Liou , Pei-Wen Shan
发明人： Yi-Jen Chen , Kuo-Sheng Hung , Yu-Hsun Kao , Jing-Ping Liou , Pei-Wen Shan
IPC分类号： C07D209/30 , C07D209/18 , C07D209/08
CPC分类号： C07D209/30 , A61K31/404 , C07D209/08 , C07D209/18
摘要： Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.
摘要翻译： 本文公开了小分子，特别是吲哚基和二氢吲哚基异肟酸盐的新用途。 吲哚基和二氢吲哚基异羟肟酸盐可用作制备用于治疗患有心力衰竭或神经元损伤的患者的药物或药物组合物的铅化合物。
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5.发明授权Isolated transgenic mammalian neural cell for detection of a sample containing a chemical substance damage to neurological system or selection of drugs for treating neurodegenerative disorders 有权分离的转基因哺乳动物神经细胞用于检测含有化学物质损伤神经系统或选择用于治疗神经变性疾病的药物的样品公开(公告)号：US08211695B2
公开(公告)日：2012-07-03
申请号：US12751718
申请日：2010-03-31
申请人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
发明人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
CPC分类号： C12N15/85 , C12N2503/02 , C12N2517/02 , C12N2800/107 , C12N2830/002 , G01N33/5058
摘要： The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.
摘要翻译： 本发明提供一种分离的转基因哺乳动物神经细胞，其包含至少一种表达AhR / ARNT的异源载体。 还提供了检测包含对神经系统损伤的化学物质的样品和用于治疗神经变性疾病的药物的选择的方法。
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公开(公告)号：US08846748B2
公开(公告)日：2014-09-30
申请号：US13074312
申请日：2011-03-29
申请人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
发明人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
IPC分类号： A61K31/404 , C07D209/12 , C07D209/40 , C07D209/08
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/30 , C07D209/40
摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
摘要翻译： 式（I）的吲哚基或二氢吲哚基化合物：其中键，n，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 还公开了用这些化合物治疗癌症的方法。
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公开(公告)号：US20080175522A1
公开(公告)日：2008-07-24
申请号：US11654538
申请日：2007-01-18
申请人： Chin-Hsin Chuang , Yu-Chuan Lin , Kuo-Sheng Hung , Ping-Yang Chen
发明人： Chin-Hsin Chuang , Yu-Chuan Lin , Kuo-Sheng Hung , Ping-Yang Chen
摘要： A packing bag having a drawing structure comprises a bag housing and a drawn slice. The bag housing has an opening on one side thereof for placing a product conveniently into the bag housing through the opening. The drawing piece is connected on a side of the bag housing. Thereby, it is easy for customers to extract the products placed in pallets as long as equal force is applied to extract upwardly the drawing piece of the packing bags without damaging the products.
摘要翻译： 具有拉伸结构的包装袋包括袋壳体和拉伸片材。 袋壳体的一侧具有开口，用于通过开口将产品方便地放入袋壳体中。 绘图件连接在袋子外壳的一侧。 因此，只要施加相等的力量，客户就可以提取放置在托盘中的产品，以向上抽出包装袋的拉伸件而不损坏产品。
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8.发明申请ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS 有权用于检测含有对神经系统的化学物质损伤的样品或选择用于治疗神经损伤性疾病的药物的分离的转基因马马里尼神经细胞公开(公告)号：US20110244470A1
公开(公告)日：2011-10-06
申请号：US12751718
申请日：2010-03-31
申请人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
发明人： Yi-Hsuan Lee , Cheng-Yu Wang , Shu-Hui Juan , Wen-Liang Chen , Kuo-Sheng Hung , Chun-Hua Lin
CPC分类号： C12N15/85 , C12N2503/02 , C12N2517/02 , C12N2800/107 , C12N2830/002 , G01N33/5058
摘要： The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.
摘要翻译： 本发明提供一种分离的转基因哺乳动物神经细胞，其包含至少一种表达AhR / ARNT的异源载体。 还提供了检测包含对神经系统损伤的化学物质的样品和用于治疗神经变性疾病的药物的选择的方法。
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