公开(公告)号：US5154897A

公开(公告)日：1992-10-13

申请号：US665331

申请日：1991-03-06

申请人： Gary J. Ehrhardt ,  Robert K. Guimon ,  Kurt R. Zinn ,  Steven Symes

发明人： Gary J. Ehrhardt ,  Robert K. Guimon ,  Kurt R. Zinn ,  Steven Symes

IPC分类号： C22B26/20 ,  C22B59/00

CPC分类号： C22B26/20 ,  C22B3/24 ,  C22B59/00 ,  Y02P10/234

摘要： A method and a generator for separating daughter radioisotope from a stock solution containing the daughter radioisotope and its parent are provided. The generator is provided with a glass adsorbent which preferentially adsorbs daughter radioisotope relative to the parent radioisotope and circulation means for withdrawing the stock solution from a reservoir, contacting the solution with the glass adsorbent to adsorb the daughter radioisotope and returning the parent radioisotope-enriched solution to the reservoir. In the process stock solution containing daughter radioisotope having a predetermined pH is contacted with the glass adsorbent to selectively adsorb the daughter radioisotope thereon and the daughter radioisotope is eluted with an eluant at a second predetermined pH. The process also includes a step of washing the glass adsorbent with a wash solution at the first predetermined pH to remove traces of the parent radioisotope from the adsorbent prior to eluting the daughter radioiotope. In the process the first predetermined pH is in the range of from 4.0 to 10.0 and the second predetermined pH is less than 4. Daughter radioisotopes such as Y-90, Ga-68 and Ca-47 can be separated from their parents using these process and generator.

摘要翻译： 提供了一种用于从含有儿子放射性同位素及其母体的储备溶液中分离子放射性同位素的方法和发生器。 该发生器设置有相对于母体放射性同位素优先吸附子放射性同位素的玻璃吸附剂和用于从储存器中取出储备溶液的循环装置，使该溶液与玻璃吸附剂接触以吸附子放射性同位素并返回母体放射性同位素富集溶液 到水库 在具有预定pH的含有儿子放射性同位素的方法储备溶液中与玻璃吸附剂接触以选择性地吸附其上的子放射性同位素，并且用第二预定pH的洗脱液洗脱子载体。 该方法还包括以洗涤溶液在第一预定pH下洗涤玻璃吸附剂的步骤，以在洗脱子女放射性物质之前从吸附剂中除去痕量的母体放射性同位素。 在该过程中，第一预定pH在4.0至10.0的范围内，第二预定pH小于4.可以使用这些方法将诸如Y-90，Ga-68和Ca-47之类的放射性同位素与其亲本分离 和发电机。

公开(公告)号：US5409677A

公开(公告)日：1995-04-25

申请号：US112765

申请日：1993-08-26

申请人： Kurt R. Zinn

发明人： Kurt R. Zinn

IPC分类号： A61K51/04 ,  C07B63/02 ,  G21G1/10 ,  C01F1/00

CPC分类号： G21G1/10 ,  A61K51/0478 ,  C07B63/02

摘要： A process for separating a radionuclide such as radioactive Cu-64 from a mixture containing the radionuclide and a precursor element from which the radionuclide is formed. A weak acid solution is prepared which contains the mixture of the radionuclide and the element. The solution is contacted with a ligand which preferentially forms a complex with the radionuclide relative to the precursor element. The radionuclide complexed to the ligand is separated from the precursor element and released from the ligand by contacting the ligand with an acid.

摘要翻译： 从含有放射性核素的混合物和形成放射性核素的前体元素分离放射性核素如放射性Cu-64的方法。 制备含有放射性核素和元素的混合物的弱酸溶液。 该溶液与优选与放射性核素相对于前体元件形成络合物的配体接触。 与配体络合的放射性核素与前体元件分离并通过使配体与酸接触而从配体释放。

公开(公告)号：US5403573A

公开(公告)日：1995-04-04

申请号：US872899

申请日：1992-04-23

申请人： Delbert E. Day ,  Gary J. Ehrhardt ,  Kurt R. Zinn

发明人： Delbert E. Day ,  Gary J. Ehrhardt ,  Kurt R. Zinn

IPC分类号： A61K51/08 ,  A61K51/12 ,  A61K43/00

CPC分类号： A61K51/1258 ,  A61K51/08 ,  A61K2121/00

摘要： A radiolabeled protein composition adapted for radiation therapy which comprises a radioisotope and a protein material containing about 6 or more percent amino acids which have a sulfhydryl-containing side chain. A method for carrying out radiation synovectomy of arthritic joints. Rhenium radiolabeled protein microspheres are administered which contain cysteine and other amino acids. A method for radiolabeling a protein composition whereby the composition is treated with a reducing agent capable of reducing disulfides to sulfhydryls prior to radiolabeling.

摘要翻译： 适于辐射治疗的放射性标记的蛋白质组合物，其包含放射性同位素和含有约6个或更多个具有含巯基侧链的氨基酸的蛋白质材料。 一种进行关节炎关节放射性滑膜切除术的方法。 施用含有半胱氨酸和其他氨基酸的铼放射性标记的蛋白质微球。 一种用于放射性标记蛋白质组合物的方法，其中组合物用能够在放射性标记之前将二硫键还原成巯基的还原剂进行处理。