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公开(公告)号:US08716270B2
公开(公告)日:2014-05-06
申请号:US13166911
申请日:2011-06-23
申请人: Eric Chellquist , Mary Doubleday , Charles W. Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人: Eric Chellquist , Mary Doubleday , Charles W. Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号: C07J31/006 , C07J41/0005
摘要: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译: 本发明涉及选择的山al胺盐,它们的合成方法,其治疗用途及其与制造有关的优点,产品的稳定性和毒性。 更具体地,本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号:US07981876B2
公开(公告)日:2011-07-19
申请号:US11410098
申请日:2006-04-25
申请人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号: C07J31/006 , C07J41/0005
摘要: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译: 本发明涉及选择的山al胺盐,它们的合成方法,其治疗用途及其与制造有关的优点,产品的稳定性和毒性。 更具体地,本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号:US20070010504A1
公开(公告)日:2007-01-11
申请号:US11410098
申请日:2006-04-25
申请人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy Levitt
发明人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy Levitt
CPC分类号: C07J31/006 , C07J41/0005
摘要: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译: 本发明涉及选择的山al胺盐,它们的合成方法,其治疗用途及其与制造有关的优点,产品的稳定性和毒性。 更具体地,本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号:US20120022035A1
公开(公告)日:2012-01-26
申请号:US13166911
申请日:2011-06-23
申请人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人: Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号: C07J31/006 , C07J41/0005
摘要: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译: 本发明涉及选择的山al胺盐,它们的合成方法,其治疗用途及其与制造有关的优点,产品的稳定性和毒性。 更具体地,本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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