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公开(公告)号：US08716270B2
公开(公告)日：2014-05-06
申请号：US13166911
申请日：2011-06-23
申请人： Eric Chellquist , Mary Doubleday , Charles W. Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人： Eric Chellquist , Mary Doubleday , Charles W. Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号： C07J31/006 , C07J41/0005
摘要： The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译： 本发明涉及选择的山al胺盐，它们的合成方法，其治疗用途及其与制造有关的优点，产品的稳定性和毒性。 更具体地，本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号：US20120022035A1
公开(公告)日：2012-01-26
申请号：US13166911
申请日：2011-06-23
申请人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号： C07J31/006 , C07J41/0005
摘要： The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译： 本发明涉及选择的山al胺盐，它们的合成方法，其治疗用途及其与制造有关的优点，产品的稳定性和毒性。 更具体地，本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号：US07981876B2
公开(公告)日：2011-07-19
申请号：US11410098
申请日：2006-04-25
申请人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
发明人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy C. Levitt
CPC分类号： C07J31/006 , C07J41/0005
摘要： The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译： 本发明涉及选择的山al胺盐，它们的合成方法，其治疗用途及其与制造有关的优点，产品的稳定性和毒性。 更具体地，本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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公开(公告)号：US20070010504A1
公开(公告)日：2007-01-11
申请号：US11410098
申请日：2006-04-25
申请人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy Levitt
发明人： Eric Chellquist , Mary Doubleday , Charles Gilbert , Xuehai Zhang , Michael McLane , Kyle Armbruster , Roy Levitt
CPC分类号： C07J31/006 , C07J41/0005
摘要： The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.
摘要翻译： 本发明涉及选择的山al胺盐，它们的合成方法，其治疗用途及其与制造有关的优点，产品的稳定性和毒性。 更具体地，本申请涉及各种形式的角质胺的稀释盐及其在抑制新生血管形成和内皮细胞增殖中的用途。
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5.发明申请Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols 有权用于制备氨基甾醇的稠环系统的区域选择性和立体选择性氧化公开(公告)号：US20050187202A1
公开(公告)日：2005-08-25
申请号：US11083961
申请日：2005-03-21
申请人： William Kinney , Xuehai Zhang , Ronald Michalak
发明人： William Kinney , Xuehai Zhang , Ronald Michalak
CPC分类号： C07J9/00 , C07J21/006 , C07J31/006 , C07J41/0005
摘要： An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
摘要翻译： 描述了合成氨基甾醇化合物如角鲨胺和化合物1436的有效方法。 本发明的方法提供稠环系统的区域选择性磺化。 稠环系统碱可以是例如类固醇环基。 氨基甾醇化合物尤其是抗生素，抗血管生成剂和NHE3抑制剂是有效的。
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公开(公告)号：US06610866B2
公开(公告)日：2003-08-26
申请号：US09833055
申请日：2001-04-12
申请人： William A. Kinney , Steven Jones , Xuehai Zhang , Meena N. Rao , Michel Bulliard , Harold Meckler , Nancy Lee
发明人： William A. Kinney , Steven Jones , Xuehai Zhang , Meena N. Rao , Michel Bulliard , Harold Meckler , Nancy Lee
IPC分类号： C07J5300
CPC分类号： C07J31/006 , C07J9/00 , C07J41/0005
摘要： A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.
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7.发明授权Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols 有权用于制备氨基甾醇的稠环系统的区域选择性和立体选择性氧化公开(公告)号：US07728157B2
公开(公告)日：2010-06-01
申请号：US11083961
申请日：2005-03-21
申请人： William A. Kinney , Xuehai Zhang , Ronald Michalak
发明人： William A. Kinney , Xuehai Zhang , Ronald Michalak
IPC分类号： C07J41/00
CPC分类号： C07J9/00 , C07J21/006 , C07J31/006 , C07J41/0005
摘要： An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
摘要翻译： 描述了合成氨基甾醇化合物如角鲨胺和化合物1436的有效方法。 本发明的方法提供稠环系统的区域选择性磺化。 稠环系统碱可以是例如类固醇环基。 氨基甾醇化合物尤其是抗生素，抗血管生成剂和NHE3抑制剂是有效的。
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公开(公告)号：US20150056839A1
公开(公告)日：2015-02-26
申请号：US14237305
申请日：2012-08-03
申请人： Xuehai Zhang
发明人： Xuehai Zhang
IPC分类号： H01R13/646 , H01R13/627 , H01R24/68
CPC分类号： H01R13/6581 , H01R12/724 , H01R13/506 , H01R13/6271 , H01R24/62
摘要： An electrical connector assembly comprises a receptacle electrical connector and a plug electrical connector. The receptacle electrical connector includes a first body having a first and a second tongues and a plurality of first terminals, the first terminals located on opposite surfaces of the first tongue and offset relative to each other. The plug electrical connector includes a second body and a third and fourth mating chambers located in the second body; a plurality of third terminals, wherein the third terminals located on upper and lower sides of the third mating chamber are offset relative to each other. The receptacle electrical connector and the plug electrical connector can mate with each other so the first terminals and the third terminals are mated with each other to transmit signals and the second tongue and the fourth mating chamber are connected to transmit power.
摘要翻译： 电连接器组件包括插座电连接器和插头电连接器。 插座电连接器包括具有第一和第二舌片和多个第一端子的第一本体，第一端子位于第一舌片的相对表面上并相对于彼此偏移。 插头电连接器包括第二主体和位于第二主体中的第三和第四配合室; 多个第三端子，其中位于第三配合室的上侧和下侧的第三端子相对于彼此偏移。 插座电连接器和插头电连接器可以彼此配合，使得第一端子和第三端子彼此配合以传输信号，并且第二舌片和第四配合室被连接以发射功率。
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公开(公告)号：US09543706B2
公开(公告)日：2017-01-10
申请号：US14237305
申请日：2012-08-03
申请人： Xuehai Zhang
发明人： Xuehai Zhang
IPC分类号： H01R13/6581 , H01R12/72 , H01R13/506 , H01R13/627
CPC分类号： H01R13/6581 , H01R12/724 , H01R13/506 , H01R13/6271 , H01R24/62
摘要： An electrical connector assembly comprises a receptacle electrical connector and a plug electrical connector. The receptacle electrical connector includes a first body having a first and a second tongues and a plurality of first terminals, the first terminals located on opposite surfaces of the first tongue and offset relative to each other. The plug electrical connector includes a second body and a third and fourth mating chambers located in the second body; a plurality of third terminals, wherein the third terminals located on upper and lower sides of the third mating chamber are offset relative to each other. The receptacle electrical connector and the plug electrical connector can mate with each other so the first terminals and the third terminals are mated with each other to transmit signals and the second tongue and the fourth mating chamber are connected to transmit power.
摘要翻译： 电连接器组件包括插座电连接器和插头电连接器。 插座电连接器包括具有第一和第二舌片和多个第一端子的第一本体，第一端子位于第一舌片的相对表面上并相对于彼此偏移。 插头电连接器包括第二主体和位于第二主体中的第三和第四配合室; 多个第三端子，其中位于第三配合室的上侧和下侧的第三端子相对于彼此偏移。 插座电连接器和插头电连接器可以彼此配合，使得第一端子和第三端子彼此配合以传输信号，并且第二舌片和第四配合室被连接以发射功率。
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10.发明授权Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols 有权用于制备氨基甾醇的稠环系统的区域选择性和立体选择性氧化公开(公告)号：US06933383B2
公开(公告)日：2005-08-23
申请号：US10268660
申请日：2002-10-11
申请人： William A. Kinney , Xuehai Zhang , Ronald Michalak
发明人： William A. Kinney , Xuehai Zhang , Ronald Michalak
CPC分类号： C07J9/00 , C07J21/006 , C07J31/006 , C07J41/0005
摘要： An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.
摘要翻译： 描述了合成氨基甾醇化合物如角鲨胺和化合物1436的有效方法。 本发明的方法提供稠环系统的区域选择性氧化和区域选择性磺化。 稠环基可以是例如类固醇环基。 氨基甾醇化合物作为例如抗生素，抗血管生成剂和NHE3抑制剂是有效的。
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