公开(公告)号：US20140227553A1

公开(公告)日：2014-08-14

申请号：US14343955

申请日：2011-10-17

申请人： Hee-Joong Im ,  Seung-Man Nam ,  Bo-Ryong Lee ,  Kyung-Bo Kim ,  Youn-Il Jung

发明人： Hee-Joong Im ,  Seung-Man Nam ,  Bo-Ryong Lee ,  Kyung-Bo Kim ,  Youn-Il Jung

IPC分类号： C21D1/34 ,  C21D9/00

CPC分类号： C21D9/0068 ,  C21D1/09 ,  C21D1/34 ,  C21D2221/00 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/28 ,  C22C38/32 ,  C22C38/38 ,  Y10T428/12674 ,  Y10T428/12757 ,  Y10T428/12799 ,  Y10T428/12937 ,  Y10T428/31678

摘要： Disclosed are a preparation method of a steel product capable of local reinforcement using laser heat treatment, and a heat hardened steel used in the method. According to the present invention, the preparation method of a steel part comprises the following steps: (a) preparing a material comprising 0.1-0.5 wt % of C, 0.1-0.5 wt % of Si, 0.5-3.0 wt % of Mn, 0.1 wt % or less of P, 0.05 wt % or less of S, 0.01-1.0 wt % of Cr, 0.1 wt % or less of Al, 0.2 wt % or less of Ti, 0.0005-0.08 wt % of B, and the balance of Fe and inevitable impurities; (b) preparing a formed product by forming the material into a predetermined shape; and (c) locally reinforcing the high strength portion by carrying out laser heat treatment on a portion requiring high strength at the formed product.

摘要翻译： 本发明公开了一种能够使用激光热处理进行局部加强的钢制品的制备方法和该方法中使用的热硬化钢。 根据本发明，钢部件的制备方法包括以下步骤：（a）制备包含0.1-0.5重量％的C，0.1-0.5重量％的Si，0.5-3.0重量％的Mn，0.1 ，0.05重量％以下的S，0.01〜1.0重量％的Cr，0.1重量％以下的Al，0.2重量％以下的Ti，0.0005〜0.08重量％的B，余量 的铁和不可避免的杂质; （b）通过将材料形成预定的形状来制备成形产品; 和（c）通过对形成的产品需要高强度的部分进行激光热处理来局部加强高强度部分。

公开(公告)号：US08735178B2

公开(公告)日：2014-05-27

申请号：US11674947

申请日：2007-02-14

申请人： Royce Mohan ,  Paola Bargagna-Mohan ,  Kyung Bo Kim

发明人： Royce Mohan ,  Paola Bargagna-Mohan ,  Kyung Bo Kim

IPC分类号： G01N33/532 ,  G01N33/534 ,  G01N33/533

CPC分类号： B09C1/08 ,  C11D3/0084 ,  C11D3/188 ,  C11D3/382 ,  C11D3/39

摘要： Novel withanolide chemical genetic probes identify the in vivo binding target of withaferin A, which is the intermediate filament type III protein vimentin. In addition, a withanolide-based small molecule screening method screens drug candidates that target intermediate filament type III proteins. The method includes introducing a tagged linker covalently bonded to the withanolide molecule to form a withanolide probe. Better or alternative small molecule compounds as potential drug candidates can be generated based on their likely affinity for the determined binding site in vimentin. The affinity labeled withanolide can also be used to find intermediate filament-associated proteins using chemical proteomics by extracting proteins from cells that were exposed to withanolide-biotin analog. The withanolide probes can be used to monitor expression of vimentin, in tumor samples or other diseased tissues. Withaferin analogs can be used as a treatment for diverse vimentin-associated disorders, such as cancers, angiofibrotic diseases, and chronic inflammation.

摘要翻译： 新型的腺苷酸化学遗传探针鉴定了与卵白蛋白A的体内结合靶，其是中间丝型III型蛋白波形蛋白。 另外，以基于羊毛脂的小分子筛选方法筛选靶向中间丝III型蛋白质的候选药物。 所述方法包括引入共价键合到所述己内酯分子上的标记接头以形成己内酯探针。 可以基于它们对波形蛋白中所确定的结合位点的可能亲和力来产生作为潜在药物候选物的更好或替代的小分子化合物。 使用化学蛋白质组学技术，通过从暴露于脱乙酰壳多糖 - 生物素类似物的细胞中提取蛋白质，也可以使用标记有烯醇化物的亲和力来发现中间丝相关蛋白。 索尔诺德探针可用于监测波形蛋白在肿瘤样品或其他患病组织中的表达。 嗜铬蛋白类似物可用作治疗多种波形蛋白相关疾病，例如癌症，血管纤维化疾病和慢性炎症。

公开(公告)号：US06831099B1

公开(公告)日：2004-12-14

申请号：US09569748

申请日：2000-05-11

申请人： Craig M. Crews ,  Mikael Elofsson ,  Ute Splittgerber ,  Ny Sin ,  Kyung Bo Kim

发明人： Craig M. Crews ,  Mikael Elofsson ,  Ute Splittgerber ,  Ny Sin ,  Kyung Bo Kim

IPC分类号： A01N4320

CPC分类号： C07K5/1016 ,  C07K5/1008 ,  C07K5/101 ,  C07K7/06

摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.

摘要翻译： 包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。 具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。 例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样和PGPH活性。 基于肽的化合物包括与环官能团相邻的吸电子基团，并且肽包括至少三个肽单元。 在其他治疗用途中，基于肽的化合物表现出抗炎和抑制细胞增殖，涉及这些化合物的治疗应用。

公开(公告)号：US09566341B1

公开(公告)日：2017-02-14

申请号：US13458366

申请日：2012-04-27

申请人： Audra Stinchcomb ,  Kyung Bo Kim ,  Ragotham Reddy Pinninti ,  Priyanka Ghosh ,  Kalpana S. Paudel

发明人： Audra Stinchcomb ,  Kyung Bo Kim ,  Ragotham Reddy Pinninti ,  Priyanka Ghosh ,  Kalpana S. Paudel

IPC分类号： A61K47/48 ,  A61K9/70 ,  A61K9/00

CPC分类号： A61K47/481 ,  A61K9/0021 ,  A61K9/7084 ,  A61K47/55 ,  C07D489/02

摘要： The presently-disclosed subject matter includes compounds including a cyclooxygenase enzyme inhibitor moiety and a moiety derived from a drug of interest. In some embodiments, the drug of interest is an opioid. In some embodiments, the compound includes a diclofenac moiety and a naltrexone or naltrexol moiety. The compounds allow for enhanced delivery rates across skin.

摘要翻译： 目前公开的主题包括包含环氧合酶抑制剂部分和衍生自目的药物的部分的化合物。 在一些实施方案中，感兴趣的药物是阿片样物质。 在一些实施方案中，所述化合物包括双氯芬酸部分和纳曲酮或纳曲酮部分。 这些化合物可以提高皮肤的输送速率。

公开(公告)号：US20120156869A1

公开(公告)日：2012-06-21

申请号：US13326810

申请日：2011-12-15

申请人： Jong-Han SHIN ,  Kyung-Bo Kim

发明人： Jong-Han SHIN ,  Kyung-Bo Kim

IPC分类号： H01L21/28

CPC分类号： H01L27/10876 ,  H01L23/485 ,  H01L27/10855 ,  H01L27/10885 ,  H01L29/1037 ,  H01L29/4236 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for fabricating a semiconductor device includes forming a hard mask pattern over a substrate, forming an isolation layer for defining an active region by using the hard mask pattern, forming a buried gate in and across the active region and the isolation layer over the substrate, forming an inter-layer dielectric layer over the substrate, forming a storage node contact hole that exposes the hard mask pattern by selectively etching the inter-layer dielectric layer, extending the storage node contact hole to expose the active region by removing the hard mask pattern exposed under the storage node contact hole, and forming a storage node contact plug that fills the extended storage node contact hole.

摘要翻译： 一种用于制造半导体器件的方法包括在衬底上形成硬掩模图案，通过使用硬掩模图案形成用于限定有源区的隔离层，在有源区和跨衬底上的隔离层中形成掩埋栅极 在衬底上形成层间电介质层，形成存储节点接触孔，通过选择性地蚀刻层间电介质层来暴露硬掩模图案，通过去除硬掩模来延伸存储节点接触孔以暴露有源区 在存储节点接触孔下暴露的图案，并形成填充扩展存储节点接触孔的存储节点接触插塞。

公开(公告)号：US07642369B2

公开(公告)日：2010-01-05

申请号：US11531129

申请日：2006-09-12

申请人： Kyung Bo Kim ,  Yik Khuan Ho

发明人： Kyung Bo Kim ,  Yik Khuan Ho

IPC分类号： C07C269/00

CPC分类号： C07D303/24 ,  C07D407/12

摘要： An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone. In addition, a method is provided for synthesizing inhibitors, which includes PI′-modified analogues. These analogues selectively bind to a major immunoproteasome catalytic subunit LMP2 and inactivate its proteolytic activity in a method of treating diseases, including myeloma and other cancers, Huntington's disease and Alzheimer's disease.

摘要翻译： 提供了一种用于制备活性离子霉素衍生物的二氢异苯菌霉素的有效新途径，其包括中间体化合物的羟基甲基取代的烯酮的合成。 此外，提供了一种合成抑制剂的方法，其包括PI'-修饰的类似物。 这些类似物选择性地结合主要的免疫蛋白酶体催化亚基LMP2，并且在治疗疾病包括骨髓瘤和其他癌症亨廷顿病和阿尔茨海默氏病的方法中使其蛋白水解活性失活。

公开(公告)号：US07476650B2

公开(公告)日：2009-01-13

申请号：US10871752

申请日：2004-06-17

申请人： Craig M. Crews ,  Mikael Elofsson ,  Ute Splittgerber ,  Kyung Bo Kim

发明人： Craig M. Crews ,  Mikael Elofsson ,  Ute Splittgerber ,  Kyung Bo Kim

IPC分类号： A01N43/02 ,  A61K38/00

CPC分类号： C07K5/1016 ,  C07K5/1008 ,  C07K5/101 ,  C07K7/06

摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.

摘要翻译： 包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。 具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。 例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样和PGPH活性。 基于肽的化合物包括与环官能团相邻的吸电子基团，并且肽包括至少三个肽单元。 在其他治疗用途中，基于肽的化合物表现出抗炎和抑制细胞增殖，涉及这些化合物的治疗应用。

公开(公告)号：US20080207574A1

公开(公告)日：2008-08-28

申请号：US11674947

申请日：2007-02-14

申请人： Royce Mohan ,  Paola Bargagna-Mohan ,  Kyung Bo Kim

发明人： Royce Mohan ,  Paola Bargagna-Mohan ,  Kyung Bo Kim

IPC分类号： A61K31/58 ,  G01N33/53 ,  C07K14/47 ,  C07J71/00

CPC分类号： B09C1/08 ,  C11D3/0084 ,  C11D3/188 ,  C11D3/382 ,  C11D3/39

摘要： Novel withanolide chemical genetic probes identify the in vivo binding target of withaferin A, which is the intermediate filament type III protein vimentin. In addition, a withanolide-based small molecule screening method screens drug candidates that target intermediate filament type III proteins. The method includes introducing a tagged linker covalently bonded to the withanolide molecule to form a withanolide probe. Better or alternative small molecule compounds as potential drug candidates can be generated based on their likely affinity for the determined binding site in vimentin. The affinity labeled withanolide can also be used to find intermediate filament-associated proteins using chemical proteomics by extracting proteins from cells that were exposed to withanolide-biotin analog. The withanolide probes can be used to monitor expression of vimentin, in tumor samples or other diseased tissues. Withaferin analogs can be used as a treatment for diverse vimentin-associated disorders, such as cancers, angiofibrotic diseases, and chronic inflammation.

摘要翻译： 新型的腺苷酸化学遗传探针鉴定了与卵白蛋白A的体内结合靶，其是中间丝型III型蛋白波形蛋白。 另外，以基于羊毛脂的小分子筛选方法筛选靶向中间丝III型蛋白质的候选药物。 所述方法包括引入共价键合到所述己内酯分子上的标记接头以形成己内酯探针。 可以基于它们对波形蛋白中所确定的结合位点的可能亲和力来产生作为潜在药物候选物的更好或替代的小分子化合物。 使用化学蛋白质组学技术，通过从暴露于脱乙酰壳多糖 - 生物素类似物的细胞中提取蛋白质，也可以使用标记有烯醇化物的亲和力来发现中间丝相关蛋白。 索尔诺德探针可用于监测波形蛋白在肿瘤样品或其他患病组织中的表达。 嗜铬蛋白类似物可用作治疗多种波形蛋白相关疾病，例如癌症，血管纤维化疾病和慢性炎症。

公开(公告)号：US20080064659A1

公开(公告)日：2008-03-13

申请号：US11531129

申请日：2006-09-12

申请人： Kyung Bo Kim ,  Yik Khuan Ho

发明人： Kyung Bo Kim ,  Yik Khuan Ho

IPC分类号： A61K31/695 ,  C07F7/02 ,  C07D303/36

CPC分类号： C07D303/24 ,  C07D407/12

摘要： An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone. In addition, a method is provided for synthesizing inhibitors, which includes PI′-modified analogues. These analogues selectively bind to a major immunoproteasome catalytic subunit LMP2 and inactivate its proteolytic activity in a method of treating diseases, including myeloma and other cancers, Huntington's disease and Alzheimer's disease.

摘要翻译： 提供了一种用于制备活性离子霉素衍生物的二氢异苯菌霉素的有效新途径，其包括中间体化合物的羟基甲基取代的烯酮的合成。 此外，提供了一种合成抑制剂的方法，其包括PI'-修饰的类似物。 这些类似物选择性地结合主要的免疫蛋白酶体催化亚基LMP2，并且在治疗疾病包括骨髓瘤和其他癌症亨廷顿病和阿尔茨海默氏病的方法中使其蛋白水解活性失活。

公开(公告)号：US08623727B2

公开(公告)日：2014-01-07

申请号：US13326810

申请日：2011-12-15

申请人： Jong-Han Shin ,  Kyung-Bo Kim

发明人： Jong-Han Shin ,  Kyung-Bo Kim

IPC分类号： H01L21/336

CPC分类号： H01L27/10876 ,  H01L23/485 ,  H01L27/10855 ,  H01L27/10885 ,  H01L29/1037 ,  H01L29/4236 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for fabricating a semiconductor device includes forming a hard mask pattern over a substrate, forming an isolation layer for defining an active region by using the hard mask pattern, forming a buried gate in and across the active region and the isolation layer over the substrate, forming an inter-layer dielectric layer over the substrate, forming a storage node contact hole that exposes the hard mask pattern by selectively etching the inter-layer dielectric layer, extending the storage node contact hole to expose the active region by removing the hard mask pattern exposed under the storage node contact hole, and forming a storage node contact plug that fills the extended storage node contact hole.

摘要翻译： 一种用于制造半导体器件的方法包括在衬底上形成硬掩模图案，通过使用硬掩模图案形成用于限定有源区的隔离层，在有源区和跨衬底上的隔离层中形成掩埋栅极 在衬底上形成层间电介质层，形成存储节点接触孔，通过选择性地蚀刻层间电介质层来暴露硬掩模图案，通过去除硬掩模来延伸存储节点接触孔以暴露有源区 在存储节点接触孔下暴露的图案，并形成填充扩展存储节点接触孔的存储节点接触插塞。