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公开(公告)号：US11015205B2
公开(公告)日：2021-05-25
申请号：US16472802
申请日：2017-12-21
发明人： Hoang Phan , Udo Conrad , Thuong Thi Ho
IPC分类号： A61K39/00 , A61K48/00 , A61K38/00 , C12N9/22 , A61K31/7088 , C12N15/82 , A61K39/12 , C07K14/005
摘要： The present invention relates to a method for production of an oligomeric protein in eukaryotic cells by co-expression of two fusion proteins in eukaryotic cells comprising a protein-S-Tag fusion protein, wherein the protein is an antigen or an antibody, and a S-protein-tail piece (tp) fusion protein. Furthermore the present invention relates to an oligomeric protein comprising at least a protein-S-Tag fusion protein and a S-protein-tail piece (tp) fusion protein, wherein the protein of the protein-S-Tag fusion protein is an antigen or an antibody, and the use in vaccines.
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公开(公告)号：US11483990B2
公开(公告)日：2022-11-01
申请号：US15770049
申请日：2016-09-13
发明人： Inna Lermontova
IPC分类号： A01H1/08 , C12N15/82 , A01H1/02 , C07K14/415 , A01H1/04
摘要： The present invention relates to non-transgenic and transgenic plants, preferably crop plants, comprising at least one mutation of the KINTEOCHORE NULL2 (KNL2) protein, especially a mutation causing a substitution of an amino acid within the KNL2 protein, preferably within the C-terminal region of the KNL2 protein, which preferably have the biological activity of a haploid inducer. Further, the present invention provides methods of generating the plants of the present invention and haploid and double haploid plants obtainable by crossing the plants of the present invention with wildtype plants as well as methods of facilitating cytoplasm exchange.
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公开(公告)号：US20230337611A1
公开(公告)日：2023-10-26
申请号：US18050259
申请日：2022-10-27
发明人： INNA LERMONTOVA
IPC分类号： A01H1/08 , C12N15/82 , C07K14/415 , A01H1/02 , A01H1/04
CPC分类号： A01H1/08 , C12N15/8267 , C12N15/8261 , C07K14/415 , C12N15/8287 , A01H1/022 , A01H1/045 , Y02A40/146
摘要： Non-transgenic and transgenic plants, preferably crop plants, comprising at least one mutation of the KINTEOCHORE NULL2 (KNL2) protein, especially a mutation causing a substitution of an amino acid within the KNL2 protein, preferably within the C-terminal region of the KNL2 protein, which preferably have the biological activity of a haploid inducer. Further are methods of generating plants and haploid and double haploid plants obtainable by crossing non-transgenic and transgenic plants with wildtype plants as well as methods of facilitating cytoplasm exchange.
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公开(公告)号：US20220338434A1
公开(公告)日：2022-10-27
申请号：US17762724
申请日：2020-09-22
发明人： Dmitri Demidov , Andreas Houben , Jörg Fuchs , Oda Weiss , Karla Meier , Inna Lermontova
摘要： The invention identifies plants carrying certain mutations, which can be used as haploid inducers or doubled haploid inducers in plant breeding. According to the invention, significant haploid induction and even doubled haploid induction rates can be observed when at least one functional mutation within a SAD-homology domain is present, wherein the functional mutation affects the expression of certain SAD-homology consensus sequences. The present invention further provides haploid and doubled haploid plants, which are obtained by contacting a first gamete from a plant as identified according to the invention with a second gamete from a plant expressing a wild-type SAD-homology domain to generate a zygote. Furthermore, the present invention relates to a method for identifying a plant having the activity of a haploid inducer or a doubled haploid inducer in a plant population.
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公开(公告)号：US20180179552A1
公开(公告)日：2018-06-28
申请号：US15814618
申请日：2017-11-16
发明人： Timothy Sharbel , José M. Corral
CPC分类号： C12N15/8287 , C12N9/22 , C12N15/8217
摘要： The present invention relates to methods for inducing apomixis in a plant, methods for the production of apomictic plants and the plants and plant seeds obtained thereby.
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