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公开(公告)号:US11987646B2
公开(公告)日:2024-05-21
申请号:US17497069
申请日:2021-10-08
申请人: Leidos, Inc.
发明人: Gabriel M. Gutierrez , James Pannucci , Michael Ryan Weil , Timothy W. Phares , Vinayaka Kotraiah , Cecille D. Browne , Peter J. Buontempo
摘要: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:US11684921B1
公开(公告)日:2023-06-27
申请号:US16988368
申请日:2020-08-07
申请人: Leidos, Inc. , Jennifer W. Sekowski
CPC分类号: B01L3/502715 , G01N1/02 , G01N33/5302 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/04 , B01L2300/0636 , B01L2300/0809 , B01L2300/123 , B01L2300/126 , G01N2001/028
摘要: The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow. The platform enables the concurrent running of multiple detection assay techniques such as lateral flow immunoassays (LFI), Isothermal molecular assays (i.e., Recombinase Polymerase Amplification, or RPA) and/or paper-based chemical assays (i.e., M8, pH paper) from a single wet or dry sample with minimal sample processing. The PDP reduces soldier overburden by decreasing size weight, and power (SWaP) as well as training time, electronic burden, while providing a flexible, customizable assay platform that can be rapidly produced, assembled, sustained, and when contaminated, easily to dispose of.
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公开(公告)号:US20230198633A1
公开(公告)日:2023-06-22
申请号:US18068608
申请日:2022-12-20
申请人: Leidos, Inc.
发明人: Allyson O’Brien , Joseph Kovba
CPC分类号: H04B10/70 , H04L9/0852
摘要: Entangled quantum photons augment a classically encrypted data message and the augmented message, classical decryption key and quantum photon augmentation key are transmitted on a single classical transmission line to a receiver. Eavesdroppers, i.e., attacks, are detected in accordance with changes to the quantum photons in the augmented message.
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公开(公告)号:US11249183B2
公开(公告)日:2022-02-15
申请号:US17039602
申请日:2020-09-30
申请人: Leidos, Inc.
发明人: John R. Kendra
摘要: A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance.
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公开(公告)号:US11233565B2
公开(公告)日:2022-01-25
申请号:US17064061
申请日:2020-10-06
申请人: Leidos, Inc.
IPC分类号: H04B10/079 , H04B10/70
摘要: Apparatus for detecting pulse optical position modulated signals with high background noise by detection of quantum arrival rate at the detector are described. Pulse signals at the detection limit are characterized by the arrival of clusters of individual photons at an optical receiver. The receiver has embedded shot noise that interferes with the detection of the signal of interest. The apparatus distinguishes the signal of interest by a measurement of the rate of arrival of the photons of the signal of interest from the ambient shot noise rate of the receiver. The apparatus determines the optimal signal detection criteria and calculates the expected bit error rate of the decoded data.
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公开(公告)号:US11041754B2
公开(公告)日:2021-06-22
申请号:US16848922
申请日:2020-04-15
申请人: Leidos, Inc.
摘要: A system and process scans a target area at a distance of 3-30 m for one or more materials. Scanning is performed by a coherent transmit beam aimed with the help of a thermal camera. The active source of the beam is a supercontinuum (SC) laser. The transmitted source beam is modulated by a high-speed Fourier-transform spectrometer prior to interaction with the target. Target reflected source beam is detected by an infrared detector, along with a reference portion of the transmitted source beam, as a series of interferograms; passed through a digitizer for digitizing the interferograms; and processed to producing spectrograms, wherein the spectrograms are indicative of one or more materials on the target.
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公开(公告)号:US11033622B2
公开(公告)日:2021-06-15
申请号:US15989750
申请日:2018-05-25
申请人: Leidos, Inc.
IPC分类号: A61K39/395 , C12N15/00 , C07K7/06 , C07K14/705 , C07K16/28 , C07K7/08 , A61K39/39 , A61P35/00 , A61K31/7105 , A61K35/17 , A61K39/00 , A61K45/06 , A61K38/00 , A61K35/76 , A61P33/06 , A61P31/04
摘要: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:US10955523B1
公开(公告)日:2021-03-23
申请号:US15804695
申请日:2017-11-06
申请人: Leidos, Inc.
发明人: Peter N. Mikhalevsky
摘要: An underwater navigation algorithm (UNA) uses acoustic signals transmitted in the ocean from sources at known positions to compute a position underwater for a vehicle that requires no initial a priori position or any ocean sound speed information or any initial GPS position that would require surfacing. The UNA consists of two parts, (1) the Cold Start Algorithm (CSA) and (2) the CSA with Modeling (CSAM). The underwater vehicle needs to be equipped with only a single hydrophone acoustic receiver and an onboard processor. The CSA requires only measuring the travel time of the end of the arrival coda (EOC) from each of the sources to compute a position. The CSAM is a post CSA procedure to calculate a higher accuracy position using the CSA position. CSAM utilizes the CSA position and a 4D sound speed field derived from an ocean 4D General Circulation Model (GCM) constrained using Ocean Acoustic Tomography (OAT) in the ocean area of operation and further includes (1) computing a modeled result with an acoustic propagation modeling code that is compared with the received acoustic data using a known procedure called “bulk shifting” and/or (2) a new proposed procedure that uses calculated group speeds from the 4D sound speed field, to provide a higher accuracy estimate of the receiver position.
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公开(公告)号:US10799555B2
公开(公告)日:2020-10-13
申请号:US15906481
申请日:2018-02-27
申请人: Leidos, Inc.
IPC分类号: A61K38/10 , A61K39/015 , A61K38/16 , A61K39/00 , A61K35/17 , A61K38/19 , A61P33/06 , A61P31/20 , A61P37/04 , A61P35/04 , A61K45/06 , C07K7/08 , C07K14/00 , A61K39/39 , A61K48/00
摘要: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:US20200316577A1
公开(公告)日:2020-10-08
申请号:US16883425
申请日:2020-05-26
发明人: Wayne E. Jones , Jian Liu , William E. Bernier , Julia B. Tollin , Danielle McCarthy , Emilly Obuya , Jared DeCoste
IPC分类号: B01J31/38 , B01J21/06 , B01J31/16 , B01J35/00 , B01J37/08 , C02F1/32 , C02F1/72 , D01D5/00 , C04B35/622 , B01J23/42 , C04B35/624 , C04B35/626 , B01J23/06 , B01J35/10 , C04B35/628
摘要: Mixed-phase TiO2 nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO2 nanofibers relative to the anatase phase. Post-calcined TiO2 nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers' specific surface areas and their phase compositions.
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