公开(公告)号：US06903132B2

公开(公告)日：2005-06-07

申请号：US10459364

申请日：2003-06-11

申请人： Mark B. Anderson ,  Lance Christopher Christie ,  Quyen-Quyen Thuy Do ,  Jun Feng ,  Yufeng Hong ,  Haitao Li ,  Ved P. Pathak ,  Ranjan Jagath Rajapakse ,  Eric T. Sun ,  Eileen Valenzuela Tompkins

发明人： Mark B. Anderson ,  Lance Christopher Christie ,  Quyen-Quyen Thuy Do ,  Jun Feng ,  Yufeng Hong ,  Haitao Li ,  Ved P. Pathak ,  Ranjan Jagath Rajapakse ,  Eric T. Sun ,  Eileen Valenzuela Tompkins

IPC分类号： C07D307/68 ,  A61K31/341 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61P5/02 ,  A61P5/04 ,  A61P13/08 ,  A61P15/00 ,  A61P15/08 ,  A61P15/16 ,  A61P25/20 ,  A61P31/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D307/46 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04 ,  C07D495/04 ,  C07D519/00 ,  C07D307/34

CPC分类号： C07D405/12 ,  A61K31/341 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/495 ,  A61K31/53 ,  C07D307/46 ,  C07D495/04

摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

公开(公告)号：US07101878B1

公开(公告)日：2006-09-05

申请号：US09763216

申请日：1999-08-20

申请人： Mark Brian Anderson ,  Haresh N. Vazir ,  David Robert Luthin ,  Genevieve DeGuzman Paderes ,  Ved P. Pathak ,  Lance Christopher Christie ,  Yufeng Hong ,  Eileen Valenzuela Tompkins ,  Haitao Li ,  James Faust

发明人： Mark Brian Anderson ,  Haresh N. Vazir ,  David Robert Luthin ,  Genevieve DeGuzman Paderes ,  Ved P. Pathak ,  Lance Christopher Christie ,  Yufeng Hong ,  Eileen Valenzuela Tompkins ,  Haitao Li ,  James Faust

IPC分类号： C07D405/12 ,  C07D307/68 ,  A61K31/34 ,  A61K31/505 ,  A61P5/04

CPC分类号： C07D307/68 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

摘要翻译： 描述了能抑制促性腺激素释放激素作用的非肽GnRH剂。 这些化合物及其药学上可接受的盐，多聚体，前药和活性代谢物适用于治疗哺乳动物生殖障碍和类固醇激素依赖性肿瘤以及调节生育能力，其中指出促性腺激素释放的抑制。 还描述了合成化合物的方法和可用于其制备的中间体。