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公开(公告)号：US06903132B2
公开(公告)日：2005-06-07
申请号：US10459364
申请日：2003-06-11
申请人： Mark B. Anderson , Lance Christopher Christie , Quyen-Quyen Thuy Do , Jun Feng , Yufeng Hong , Haitao Li , Ved P. Pathak , Ranjan Jagath Rajapakse , Eric T. Sun , Eileen Valenzuela Tompkins
发明人： Mark B. Anderson , Lance Christopher Christie , Quyen-Quyen Thuy Do , Jun Feng , Yufeng Hong , Haitao Li , Ved P. Pathak , Ranjan Jagath Rajapakse , Eric T. Sun , Eileen Valenzuela Tompkins
IPC分类号： C07D307/68 , A61K31/341 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/443 , A61K31/4709 , A61K31/495 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/53 , A61P5/02 , A61P5/04 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/16 , A61P25/20 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P43/00 , C07D307/46 , C07D405/12 , C07D405/14 , C07D471/04 , C07D495/04 , C07D519/00 , C07D307/34
CPC分类号： C07D405/12 , A61K31/341 , A61K31/435 , A61K31/4353 , A61K31/495 , A61K31/53 , C07D307/46 , C07D495/04
摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
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2.发明授权Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use 失效非肽GnRH剂，药物组合物及其使用方法公开(公告)号：US06833372B2
公开(公告)日：2004-12-21
申请号：US10364193
申请日：2003-02-11
申请人： Lance C. Christie , Mark B. Anderson , Jun Feng , Yufeng Hong , Ved P. Pathak , Ranjan J. Rajapakse , Eileen V. Tompkins , Haresh Vazir , Haitao Li
发明人： Lance C. Christie , Mark B. Anderson , Jun Feng , Yufeng Hong , Ved P. Pathak , Ranjan J. Rajapakse , Eileen V. Tompkins , Haresh Vazir , Haitao Li
IPC分类号： A61K31505
CPC分类号： C07D405/14 , C07D405/12 , C07D471/04
摘要： Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated.
摘要翻译： 描述了抑制促性腺激素释放激素作用的非肽GnRH剂。 这些药剂可用于治疗哺乳动物生殖障碍和类固醇激素依赖性肿瘤以及调节生育能力，其中指出促性腺激素释放的抑制。
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3.发明授权公开(公告)号：US08476285B2
公开(公告)日：2013-07-02
申请号：US12494917
申请日：2009-06-30
申请人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： Ashok C. Bajji , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： A61K31/52 , C07D473/34 , A61P35/00
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group; R1 is chosen from hydro, alkyl, aryl, heteroaryl, amino, or halo; and L1, L2, are as defined herein.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途，其中A选自取代或未取代的芳基，杂芳基，杂环或碳环基团; B选自取代或未取代的哌啶，高哌啶，哌嗪，吡咯烷或氮杂环丁烷基; R 1选自氢，烷基，芳基，杂芳基，氨基或卤素; 和L1，L2如本文所定义。
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4.发明申请公开(公告)号：US20100292255A1
公开(公告)日：2010-11-18
申请号：US12780828
申请日：2010-05-14
申请人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
发明人： Ashok C. Bajji , Se-Ho Kim , Rajendra Tangallapally , Benjamin J. Markovitz , Richard Trovato , Mark B. Anderson , Daniel A. Wettstein , Mark D. Shenderovich
IPC分类号： A61K31/52 , C07D473/36 , A61P35/00
CPC分类号： C07D473/34
摘要： The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders, such as cancer.
摘要翻译： 本发明提供新颖的治疗化合物，包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗疾病和病症如癌症的方法。
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公开(公告)号：US20100216862A1
公开(公告)日：2010-08-26
申请号：US12775253
申请日：2010-05-06
IPC分类号： A61K31/402 , C07D207/327 , A61P25/28 , C12N5/071
CPC分类号： C07D207/327 , C07D207/325 , C07D207/33 , C07D207/34
摘要： Novel pyrrole derivatives are disclosed as Aβ42-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the Aβ42 peptide.
摘要翻译： 公开了新颖的吡咯衍生物作为治疗和预防神经变性疾病的42降低剂，其特征在于包含Aβ42肽的淀粉样蛋白斑的形成或积累。
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公开(公告)号：US20080249135A1
公开(公告)日：2008-10-09
申请号：US11696526
申请日：2007-04-04
申请人： Rachel Slade , Yevgeniya Klimova , Robert J. Halter , Ashantai J. Yungai , Warren S. Weiner , Ruth J. Walton , Jon Adam Willardsen , Mark B. Anderson , Kenton Zavitz
发明人： Rachel Slade , Yevgeniya Klimova , Robert J. Halter , Ashantai J. Yungai , Warren S. Weiner , Ruth J. Walton , Jon Adam Willardsen , Mark B. Anderson , Kenton Zavitz
IPC分类号： A61K31/44 , A61K31/404 , A61P25/28 , C07D257/04 , C07D401/00 , C07D209/04 , A61K31/41
CPC分类号： C07D209/60 , A61K31/403 , C07D209/08 , C07D209/10 , C07D209/14 , C07D231/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/10 , C07F7/1804
摘要： The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH2, -L-C(═O)NH(C1-3 alkyl), -L-C(═O)N(C1-3 alkyl)2, -L-S(═O)2(C1-3alkyl), -L-S(═O)2NH2, -L-S(═O)2N(C1-3 alkyl)2, -L-S(═O)2NH(C1-3 alkyl), -L-C(═O)NHOH, -L-C(═O)CH2NH2, -L-C(═O)CH2OH, -L-C(═O)CH2SH, -L-C(═O)NHCN, -L-NHC(═O)ORo, -L-C(═O)NHRo, -L-NH(C═O)NHRo, -L-C(═O)N(Ro)2, -L-NH(C═O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.
摘要翻译： 本发明提供了可用于治疗包括阿尔茨海默病和痴呆的神经变性疾病的新化合物。 化合物具有选自-LC（-O）OH，-L-CH-CHC（-O）OH，-LC（-O）NH 2，-LC（-O）NH （C 1-3烷基），-LC（-O）N（C 1-3烷基）亚磺酰基，-LS（-O ）2（C 1-3烷基），-LS（-O）2 NH 2，-LS （-O）2 N（C 1-3烷基）2，-LS（-O）2 NH（C 1-3烷基），-LC（-O）NHOH，-LC（-O）CH 2 NH 2 - ， - LC（-O）CH 2 OH，-LC（-O）CH 2 SH，-LC（-O）NHCN，-L-NHC（-O）OR -OC（-O）NHR o，-L-NH（CO）NHR o，-LC（-O）N（ 2-N，R-NH（CO）N（R 0）2 - ， - 磺基，-L-（2,6-二氟苯酚），-L-膦酰基和-L-四唑基，其中L是连接体。
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7.发明授权Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (e-selectin) and LECAM-1 (l-selectin) 失效三萜酸的衍生物作为细胞粘附分子的抑制剂ELAM-1（e-选择蛋白）和LECAM-1（l-选择素）
公开(公告)号：US5624909A
公开(公告)日：1997-04-29
申请号：US468888
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K31/704 , A61K49/00 , A61K51/00 , A61K51/04 , A61P29/00 , C07H15/18 , C07H15/203 , C07H15/207 , C07H15/24 , C07H15/256 , C07H17/04 , C07J63/00 , A01N37/00 , A01N39/00 , A61K31/00 , A61K31/56
CPC分类号： C07J63/008 , A61K51/04 , C07H15/18 , C07H15/203 , C07H15/24 , C07H15/256 , C07H17/04 , A61K2121/00
摘要： Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.
摘要翻译： 已经发现三萜酸衍生物具有与天然配体相似的结构，使得这些衍生物与天然选择素受体结合，包括内皮白细胞粘附分子-1（ELAM-1）和白细胞/内皮细胞粘附分子-1（LECAM-1） 。 分子可以自己或以药物制剂施用于患者，以减轻炎症和/或治疗与白细胞与内皮受体的过度结合相关的其它异常。
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8.发明授权Method and apparatus for improving digital predistortion correction with amplifier device biasing 有权用于利用放大器装置偏置改善数字预失真校正的方法和装置公开(公告)号：US08374282B2
公开(公告)日：2013-02-12
申请号：US12179035
申请日：2008-07-24
IPC分类号： H04L25/49
CPC分类号： H04L27/367 , H03F1/30 , H03F1/3241 , H03F3/195 , H03F3/24 , H03F2200/447 , H03F2200/451 , H03F2200/465 , H03F2201/3233
摘要： A method, apparatus, and electronic device for using digital predistortion are disclosed. A transmitter 212 may transmits a transmission signal. A receiver 214 may monitor the transmission signal to execute digital predistortion of the transmission signal to compensate for distortion. A field programmable gate array or application specific integrated circuit 226 may adjust a power amplifier bias to improve the digital predistortion.
摘要翻译： 公开了一种使用数字预失真的方法，装置和电子设备。 发送器212可以发送发送信号。 接收器214可以监视发送信号以执行发送信号的数字预失真以补偿失真。 现场可编程门阵列或专用集成电路226可以调整功率放大器偏置以改善数字预失真。
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公开(公告)号：US20100093773A1
公开(公告)日：2010-04-15
申请号：US12574632
申请日：2009-10-06
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , C07D239/94
摘要： Disclosed is (4-Methoxy-phenyl)-methyl-(2-methyl-quinazolin-4-yl)-amine hydrochloride effective as a vascular disrupting agent. (4-Methoxy-phenyl)-methyl-(2-methyl-quinazolin-4-yl)-amine hydrochloride is useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to its use in treating cancer.
摘要翻译： 公开了作为血管破坏剂有效的（4-甲氧基 - 苯基） - 甲基 - （2-甲基 - 喹唑啉-4-基） - 胺盐酸盐。 （4-甲氧基 - 苯基） - 甲基 - （2-甲基 - 喹唑啉-4-基） - 胺盐酸盐可用于治疗异常细胞发生不受控生长和扩散的各种临床病症，特别是 其用于治疗癌症。
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公开(公告)号：US20100016586A1
公开(公告)日：2010-01-21
申请号：US12494917
申请日：2009-06-30
申请人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
发明人： ASHOK C. BAJJI , Se-Ho Kim , Benjamin Markovitz , Richard Trovato , Rajendra Tangallapally , Mark B. Anderson , Daniel Wettstein , Mark Shenderovich , John A. Vanecko
IPC分类号： C07D413/14 , C07D473/34
CPC分类号： A61K31/52 , A61K31/522 , C07D473/34
摘要： The invention relates to compounds of Formulae I-III and their therapeutic uses.
摘要翻译： 本发明涉及式I-III的化合物及其治疗用途。
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