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公开(公告)号：US5049820A
公开(公告)日：1991-09-17
申请号：US633184
申请日：1990-12-28
申请人： Jacques Briand , Laurance D. Hall
发明人： Jacques Briand , Laurance D. Hall
IPC分类号： G01R33/44 , A61B5/055 , G01R33/48 , G01R33/483
CPC分类号： G01R33/4833
摘要： A magnetic resonance signal of a volume of interest within an object is acquired by placing the object in a magnetic field and the application of three successive steps. The first step comprises an rf selective 90.degree. pulse of frequency f.sub.x applied in the presence of an x-gradient magnetic field to select a slice. The magnetization of the slice is then inverted. In the second step an rf selective 90.degree. pulse of frequency f.sub.y is applied in the presence of a y-gradient magnetic field to excite a strip of the slice, in the third step an rf selective 180.degree. pulse of frequency f.sub.z is applied in the presence of a y-gradient magnetic field to refocus the magnetization of a region of said strip. The resulting free induction signal is derived solely from said region.
摘要翻译： 通过将物体放置在磁场中并且应用三个连续的步骤来获取物体内感兴趣体积的磁共振信号。 第一步包括在存在x梯度磁场的情况下施加频率fx的rf选择性90度脉冲以选择切片。 然后切片的磁化反转。 在第二步中，在存在y梯度磁场的情况下施加频率fy的rf选择性90°脉冲以激励切片的条带，在第三步中，将频率fz的rf选择性180°脉冲施加在 存在y梯度磁场以重新聚焦所述条带的区域的磁化。 所得到的自由感应信号仅来自所述区域。
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2.发明授权
公开(公告)号：US4703270A
公开(公告)日：1987-10-27
申请号：US853447
申请日：1986-04-18
CPC分类号： G01R33/445 , G01R33/46 , G01R33/482
摘要： Zero-quantum nuclear magnetic resonance imaging and spectroscopy in an inhomogeneous or low homogeneity magnetic field are disclosed. Specific pulse sequences have been developed which produce zero-quantum coherence resolved images and spectra. Unlike conventional NMR resolved images and spectra the zero-quantum coherence resolved images and spectra are unaffected by magnetic field inhomogeneity, thereby allowing the images and spectra of substances to be obtained where magnetic field inhomogeneity would previously have made it impossible.
摘要翻译： 公开了零均衡或低均匀磁场中的零量子核磁共振成像和光谱学。 已经开发了产生零量子相干分辨图像和光谱的特定脉冲序列。 与常规NMR分辨图像和光谱不同，零量子相干分辨图像和光谱不受磁场不均匀性的影响，从而允许在磁场不均匀性先前已经使得不可能的情况下获得物质的图像和光谱。
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公开(公告)号：US5045790A
公开(公告)日：1991-09-03
申请号：US229156
申请日：1988-08-05
CPC分类号： G01R33/4608
摘要： A method of investigating a sample using nuclear magnetic resonance comprisesi) applying a magnetic field across the sample;ii) creating zero quantum coherences (ZQCs) within the sample during a preparation period of duration .tau.;iii) allowing the zero quantum coherences to evolve for a period of at least N.DELTA.+t.sub.1, where .DELTA., t.sub.1 are constant time intervals and N is an integer;iv) at the end of the step iii) applying a cohernece transfer pulse to create single quantum coherences;v) after a period .tau., collecting the free induction decay signal from the sample;vi) repeating steps ii) to v) with different values of N; and,vii) combining at least some of the free induction decay (FID) signals collected to generate the FID due to a single ZQC.
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公开(公告)号：US4520316A
公开(公告)日：1985-05-28
申请号：US488415
申请日：1983-04-25
CPC分类号： G01R33/483 , G01R33/485
摘要： A method of obtaining an NMR spectrum for at least a portion of a specimen slice is provided. The method comprises acquiring a number of projections of the specimen slice and shifting the projections by .DELTA.f for any point of interest. The shifted projections are then summed or compared to produce a resultant point spectrum. Preferably, shifted projections in each of a plurality of selected sets thereof are compared so as to produce a plurality of resultant spectra for the point which are used to produce a first iterated point spectrum. Additional stages of iteration are provided to minimize the effect of artifacts which comprises comparing aligned corresponding positions on an i iterated spectrum with a previously uncompared resultant point spectrum, so as to produce an i+1 iterated spectrum for the point, and repeating the foregoing a plurality of times, in each case using the iterated spectrum from the previous iteration as the i iterated spectrum.
摘要翻译： 提供了一种获得用于至少一部分样品片的NMR光谱的方法。 该方法包括获取样本片段的多个投影并且通过DELTA f将投影移动到任何兴趣点。 然后将移位的投影相加或比较以产生合成点谱。 优选地，将多个选定组中的每一组中的偏移投影进行比较，以产生用于产生第一迭代点光谱的点的多个合成光谱。 提供迭代的附加阶段以最小化伪像的影响，其包括将i迭代频谱上的对准的对应位置与先前未比较的结果点频谱进行比较，以便产生该点的i + 1迭代频谱，并重复前述 在每种情况下，使用来自先前迭代的迭代频谱作为迭代频谱，多次。
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公开(公告)号：US4570120A
公开(公告)日：1986-02-11
申请号：US488414
申请日：1983-04-25
CPC分类号： G01R33/54
摘要： A method of obtaining an N.M.R. image of a specimen slice in the a-b plane is provided. The method comprises tipping the magnetization vector by an angle other than 180.degree.. The magnetization is then repeatedly reversed 180.degree. so as to produce a spin echo train. Simultaneously with the preceding steps, G.sub.a and G.sub.b sequences are applied in which the values of G.sub.a and G.sub.b remain constant over each spin echo while the absolute values or preferable their actual values thereof change from respective adjacent spin echoes, preferably incrementally in co-sinusoidal relationship. The tipping and reversing of the magnetization vector is preferably accomplished by means of rf pulses.
摘要翻译： 一种获得N.M.R.的方法 提供a-b平面中的样本片的图像。 该方法包括将磁化矢量倾斜180°以外的角度。 然后将磁化反复反转180°，以产生自旋回波串。 与上述步骤同时，应用Ga和Gb序列，其中Ga和Gb的值在每个自旋回波上保持恒定，而绝对值或优选其实际值从相应的相邻自旋回波变化，优选地以共正弦关系递增 。 磁化矢量的倾翻和反转优选通过rf脉冲来实现。
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公开(公告)号：US4424346A
公开(公告)日：1984-01-03
申请号：US270414
申请日：1981-06-04
申请人： Laurance D. Hall , Mansur Yalpani
发明人： Laurance D. Hall , Mansur Yalpani
CPC分类号： C08B37/003
摘要： Derivatives have been formed from chitins and chitosans in which the amine residues on the polyglucosamine have been modified to form the groups: (a) --N.dbd.CHR or --NHCH.sub.2 R (b) --NHR' (c) --NHR" and (d) --NH--CH.sub.2 CO.sub.2 H or --NH--glyceryl where R is an aromatic moiety having at least one hydroxyl or carboxyl group, or a macrocyclic ligand R' is an aldose or ketose residue, and, R" is an organometallic aldehyde residue. These derivatives are useful in chelating metals, in pharmaceutical formulations, in cosmetics, in chromatographic separations, in enzyme immobilization, as catalysts, etc. Galactomannans having selected amine-containing side chains have also been prepared by reductive amination.
摘要翻译： 衍生物已经由壳多糖和壳聚糖形成，其中多葡糖胺上的胺残基已被修饰形成以下基团：（a）-N = CHR或-NHCH 2 R（b）-NHR'（c）-NHR“和（d ）-NH-CH 2 CO 2 H或-NH-甘油基，其中R是具有至少一个羟基或羧基的芳族部分，或大环配体R'是醛糖或酮糖残基，R“是有机金属醛残基。 这些衍生物可用于螯合金属，药物制剂，化妆品，色谱分离，酶固定化，催化剂等。具有选择的含胺侧链的半乳甘露聚糖也可通过还原胺化制备。
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