Anti-viral and immuno stimulator polynucleotide duplex and use thereof
    2.
    发明授权
    Anti-viral and immuno stimulator polynucleotide duplex and use thereof 失效
    抗病毒和免疫刺激多核苷酸双链体及其用途

    公开(公告)号:US6080726A

    公开(公告)日:2000-06-27

    申请号:US946023

    申请日:1992-09-11

    IPC分类号: A61K31/70

    CPC分类号: A61K31/712

    摘要: A method of treating HSV-2 infection which comprises administering to a host subject to said infection an effective amount of a polynucleotide of the formula polyrI.polyr(C.sub.12 U) where n is an integer from 4 to 29. The polynucleotide is advantageously administered intranasally.

    摘要翻译: 一种治疗HSV-2感染的方法,其包括向受所述感染的宿主施用有效量的多聚赖氨酸(C12U)的多核苷酸,其中n为4至29的整数。所述多核苷酸有利地是鼻内施用。

    Vaccine composition for herpes simplex virus and methods of using
    4.
    发明授权
    Vaccine composition for herpes simplex virus and methods of using 失效
    用于单纯疱疹病毒的疫苗组合物和使用方法

    公开(公告)号:US06207168B1

    公开(公告)日:2001-03-27

    申请号:US09413512

    申请日:1999-10-06

    申请人: Laure Aurelian

    发明人: Laure Aurelian

    IPC分类号: A61K39245

    摘要: The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.

    摘要翻译: 本发明公开了一种新型的单纯疱疹病毒疫苗组合物,其包含具有致癌基因缺失的全部活的HSV-2病毒。 还包括使用疫苗组合物的方法。

    Serological assay for herpes
    8.
    发明授权
    Serological assay for herpes 失效
    血清学检测疱疹

    公开(公告)号:US5919616A

    公开(公告)日:1999-07-06

    申请号:US989291

    申请日:1997-12-12

    摘要: The present method relates to the serological detection of herpes simplex virus type 2 (HSV-2) infection by means of reaction of a patient serum with a peptide specific to HSV-2 having the sequence Ala-Arg-Ser-Pro-Glu -Arg-Gln-Glu-Pro-Arg-Glu-Pro-Glu. The peptide may be further modified by the addition of a Cys or a biotin molecule. The peptide may be used in any of a number of assays including enzyme linked immunosorbent assay (ELISA), a radioimmunoassay (RIA), and other forms of immunoassay such as enzyme immunoblotting assay on a suitable adsorbent paper or an agglutination assay using the peptide composition as the antigen.

    摘要翻译: 本方法涉及通过患者血清与具有序列Ala-Arg-Ser-Pro-Glu-Arg的HSV-2特异性肽的反应的2型单纯疱疹病毒(HSV-2)感染的血清学检测 -Gln-Glu-Pro-Arg-Glu-Pro-Glu。 可以通过添加Cys或生物素分子进一步修饰肽。 肽可用于许多测定中的任一种,包括酶联免疫吸附测定(ELISA),放射免疫测定(RIA)和其它形式的免疫测定,例如在合适的吸附纸上的酶免疫印迹测定或使用肽组合物的凝集测定 作为抗原。