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公开(公告)号：US07762977B2
公开(公告)日：2010-07-27
申请号：US11216536
申请日：2005-08-31
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61F2/064 , A61M1/1006 , A61M1/1008 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , A61M39/10
摘要： Vascular access systems for performing hemodialysis are disclosed. The vascular access system contemplates a catheter section adapted for insertion into a vein and a graft section adapted for attachment to an artery. The catheter section may have metal or polymer wall reinforcements that allow the use of thin-walled, small outer diameter conduits for the vascular access system. One or more of the adhered, embedded or bonded conduit reinforcement structures may be removable without significant damage to the conduit sections to facilitate attachment of the sections, or to a connector between the sections. Various self-sealing materials are provided for use in the vascular access system, as well as temporary access sites and flow control/sensor systems.
摘要翻译： 公开了用于进行血液透析的血管通路系统。 血管通路系统设想适于插入静脉的导管部分和适于附接到动脉的移植部分。 导管部分可以具有允许使用用于血管通路系统的薄壁的小外径导管的金属或聚合物壁增强件。 粘合的，嵌入的或粘合的导管加强结构中的一个或多个可以是可移除的，而不会对管道部分造成显着的损害，以便于部分的连接或部分之间的连接器的连接。 提供各种自密封材料用于血管通路系统以及临时进入位置和流量控制/传感器系统。
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2.发明授权
公开(公告)号：US6162494A
公开(公告)日：2000-12-19
申请号：US538316
申请日：2000-03-30
IPC分类号： A61B5/00 , C08F2/04 , C08F2/48 , C08F2/50 , C08F220/54 , C08F220/58 , G01N21/64 , G01N21/77 , B05D5/06
CPC分类号： A61B5/14539 , A61B5/1459 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , G01N2021/7786
摘要： A method for making a optical sensor for measuring the pH of a fluid includes the steps of applying a solution containing (a) a cellulose acrylamide, (b) an acrylamide, and (c) a copolymerizable monomeric fluorescent indicator species to the distal end of an optical fiber and polymerizing the solution to form a pH sensor means.
摘要翻译： 制造用于测量流体pH值的光学传感器的方法包括以下步骤：将包含（a）纤维素丙烯酰胺，（b）丙烯酰胺和（c）可共聚单体荧光指示剂物质的溶液施加到 光纤并聚合该溶液以形成pH传感器装置。
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3.发明授权Membranes and optical sensors made therewith having improved barrier properties 失效由此制成的膜和光学传感器具有改进的阻挡性能
公开(公告)号：US6139799A
公开(公告)日：2000-10-31
申请号：US991395
申请日：1997-12-16
IPC分类号： A61B5/00 , C08F2/04 , C08F2/48 , C08F2/50 , C08F220/54 , C08F220/58 , G01N21/64 , G01N21/77
CPC分类号： A61B5/14539 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , A61B5/1459 , G01N2021/7786
摘要： The present invention discloses novel polymer compositions comprising cellulose acrylamide, acrylamide and/or a fluorescent indicator species, and membranes made with these compositions. Optical pH sensors for monitoring the pH in a fluid sample, and methods for making such pH sensors are also disclosed. The pH sensors have reduced sensitivity to sample components that can interfere with pH measurements.
摘要翻译： 本发明公开了包含纤维素丙烯酰胺，丙烯酰胺和/或荧光指示剂物质的新型聚合物组合物，以及用这些组合物制成的膜。 还公开了用于监测流体样品中的pH的光学pH传感器以及用于制备这种pH传感器的方法。 pH传感器对可能干扰pH测量的样品成分的敏感性降低。
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公开(公告)号：US20110060264A1
公开(公告)日：2011-03-10
申请号：US12831092
申请日：2010-07-06
IPC分类号： A61M1/00
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61F2/064 , A61M1/1006 , A61M1/1008 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , A61M39/10
摘要： Vascular access systems for performing hemodialysis are disclosed. The vascular access system contemplates a catheter section adapted for insertion into a vein and a graft section adapted for attachment to an artery. The catheter section may have metal or polymer wall reinforcements that allow the use of thin-walled, small outer diameter conduits for the vascular access system. One or more of the adhered, embedded or bonded conduit reinforcement structures may be removable without significant damage to the conduit sections to facilitate attachment of the sections, or to a connector between the sections. Various self-sealing materials are provided for use in the vascular access system, as well as temporary access sites and flow control/sensor systems.
摘要翻译： 公开了用于进行血液透析的血管通路系统。 血管通路系统设想适于插入静脉的导管部分和适于附接到动脉的移植部分。 导管部分可以具有允许使用用于血管通路系统的薄壁的小外径导管的金属或聚合物壁增强件。 粘合的，嵌入的或粘合的导管加强结构中的一个或多个可以是可移除的，而不会对管道部分造成显着的损害，以便于部分的连接或部分之间的连接器的连接。 提供各种自密封材料用于血管通路系统以及临时进入位置和流量控制/传感器系统。
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公开(公告)号：US06441057B1
公开(公告)日：2002-08-27
申请号：US09538319
申请日：2000-03-30
IPC分类号： C08F248
CPC分类号： A61B5/14539 , A61B5/1459 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , G01N2021/7786
摘要： The present invention discloses novel polymer compositions comprising cellulose acrylamide, acrylamide and/or a fluorescent indicator species, and membranes made with these compositions. Optical pH sensors for monitoring the pH in a fluid sample, and methods for making such pH sensors are also disclosed. The pH sensors have reduced sensitivity to sample components that can interfere with pH measurements.
摘要翻译： 本发明公开了包含纤维素丙烯酰胺，丙烯酰胺和/或荧光指示剂物质的新型聚合物组合物，以及用这些组合物制成的膜。 还公开了用于监测流体样品中的pH的光学pH传感器以及用于制备这种pH传感器的方法。 pH传感器对可能干扰pH测量的样品成分的敏感性降低。
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6.发明授权
公开(公告)号：US6159536A
公开(公告)日：2000-12-12
申请号：US538318
申请日：2000-03-30
IPC分类号： A61B5/00 , C08F2/04 , C08F2/48 , C08F2/50 , C08F220/54 , C08F220/58 , G01N21/64 , G01N21/77 , B05D5/06 , B05D1/38
CPC分类号： A61B5/14539 , A61B5/1459 , C08F220/54 , C08F220/58 , G01N21/6428 , G01N21/7703 , G01N2021/7786
摘要： A method for making a fiber optic sensor includes the steps of applying an adhesive composition to the distal end of an optical fiber, and applying a solution containing a copolymer of (a) a cellulose acrylamide, (b) an acrylamide, and (c) a copolymerizable monomeric fluorescent indicator species thereto to form a sensing layer.
摘要翻译： 制造光纤传感器的方法包括以下步骤：将粘合剂组合物施加到光纤的远端，并施加含有（a）纤维素丙烯酰胺，（b）丙烯酰胺和（c） 可共聚的单体荧光指示剂来形成感测层。
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公开(公告)号：US08690815B2
公开(公告)日：2014-04-08
申请号：US12831092
申请日：2010-07-06
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61F2/064 , A61M1/1006 , A61M1/1008 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , A61M39/10
摘要： Vascular access systems for performing hemodialysis are disclosed. The vascular access system contemplates a catheter section adapted for insertion into a vein and a graft section adapted for attachment to an artery. The catheter section may have metal or polymer wall reinforcements that allow the use of thin-walled, small outer diameter conduits for the vascular access system. One or more of the adhered, embedded or bonded conduit reinforcement structures may be removable without significant damage to the conduit sections to facilitate attachment of the sections, or to a connector between the sections. Various self-sealing materials are provided for use in the vascular access system, as well as temporary access sites and flow control/sensor systems.
摘要翻译： 公开了用于进行血液透析的血管通路系统。 血管通路系统考虑适于插入静脉的导管部分和适于附接到动脉的移植部分。 导管部分可以具有允许使用用于血管通路系统的薄壁的小外径导管的金属或聚合物壁增强件。 粘合的，嵌入的或粘合的导管加强结构中的一个或多个可以是可移除的，而不会对管道部分造成显着的损害，以便于部分的连接或部分之间的连接器的连接。 提供各种自密封材料用于血管通路系统以及临时进入位置和流量控制/传感器系统。
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公开(公告)号：US5976085A
公开(公告)日：1999-11-02
申请号：US946597
申请日：1997-10-07
IPC分类号： G01N1/00 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/155 , G01N27/26 , G01N27/416 , G01N33/487
CPC分类号： A61B5/157 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150992 , A61B5/155
摘要： A method is provided for calibrating sensors used to analyze characteristics of physiologic fluids such as blood. The method involves the use of a sensor assembly having an analyte-responsive sensor in communication with a passageway which is in divertable fluid communication with a physiologic line and a conduit by which a reference sample may be introduced into the passageway. The method involves exposing the sensor to the reference sample, thereby producing a sensor response. The method also allows performing quality control on the sensors. Also provided is an apparatus with which the claimed method may be practiced.
摘要翻译： 提供了一种用于校准用于分析生理液体如血液的特征的传感器的方法。 该方法包括使用具有分析物响应传感器的传感器组件，该传感器组件与通道相连通，所述通道可与生理线路和可以将参考样品引入通道的导管间流通。 该方法包括将传感器暴露于参考样品，从而产生传感器响应。 该方法还允许对传感器执行质量控制。 还提供了可以实施所要求保护的方法的装置。
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公开(公告)号：US5697366A
公开(公告)日：1997-12-16
申请号：US379332
申请日：1995-01-27
IPC分类号： G01N1/00 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/155 , G01N27/26 , G01N27/416 , G01N33/487
CPC分类号： A61B5/157 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150992 , A61B5/155
摘要： A method is provided for calibrating sensors used to analyze characteristics of physiologic fluids such as blood. The method involves the use of a sensor assembly having an analyte-responsive sensor in communication with a passageway which is in divertable fluid communication with a physiologic line and a conduit by which a reference sample may be introduced into the passageway. The method involves exposing the sensor to the reference sample, thereby producing a sensor response. The method also allows performing quality control on the sensors. Also provided is an apparatus with which the claimed method may be practiced.
摘要翻译： 提供了一种用于校准用于分析生理液体如血液的特征的传感器的方法。 该方法包括使用具有分析物响应传感器的传感器组件，该传感器组件与通道相连通，所述通道可与生理线路和可以将参考样品引入通道的导管间流通。 该方法包括将传感器暴露于参考样品，从而产生传感器响应。 该方法还允许对传感器执行质量控制。 还提供了可以实施所要求保护的方法的装置。
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公开(公告)号：US20080167595A1
公开(公告)日：2008-07-10
申请号：US12054128
申请日：2008-03-24
IPC分类号： A61M39/00
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61F2/064 , A61M1/1008 , A61M1/12 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3661 , A61M39/10
摘要： Methods and devices are disclosed for connecting implantable body fluid conduits, such as catheters and grafts for AV shunts. A connector with thin connector walls at the lumen openings provides a connecting lumen that is close to flush with the lumens of the attached conduits. A tapered, smooth walled connector lumen allows connection of conduits with different internal diameters while preserving laminar flow in the transition between different conduit diameters. Rounding of the connector edges at the lumen openings further reduce disturbances in flow.
摘要翻译： 公开了用于连接可植入体液管道的方法和装置，例如用于AV分流器的导管和移植物。 在管腔开口处具有薄连接器壁的连接器提供了接近与所附连接导管的内腔齐平的连接腔。 锥形，平滑的壁连接器内腔允许连接具有不同内径的导管，同时保持在不同导管直径之间的过渡中的层流。 在管腔开口处的连接器边缘的四舍五入进一步减少了流动的干扰。
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