公开(公告)号：US20120046317A1

公开(公告)日：2012-02-23

申请号：US13318740

申请日：2010-05-06

Applicant: Chaitanya Dutt ,  Vijay Chauthaiwale ,  Ramesh Chandra Gupta ,  Manish Patel ,  Jignesh Kotecha ,  Sachin Latad ,  Jaya Abraham ,  Sanjay Srivastava ,  Milin Rode ,  Shailesh Deshpande ,  Anita Chaudhary ,  Amit Kumar Kesarwani

Inventor： Chaitanya Dutt ,  Vijay Chauthaiwale ,  Ramesh Chandra Gupta ,  Manish Patel ,  Jignesh Kotecha ,  Sachin Latad ,  Jaya Abraham ,  Sanjay Srivastava ,  Milin Rode ,  Shailesh Deshpande ,  Anita Chaudhary ,  Amit Kumar Kesarwani

IPC: A61K31/4535 ,  C07D213/54 ,  C07D211/34 ,  C07D409/02 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/435 ,  A61K31/445 ,  A61P25/00 ,  A61P9/12 ,  A61P9/04 ,  A61P27/02 ,  A61P9/10 ,  A61P25/28 ,  A61P13/12 ,  A61P17/00 ,  C07D409/14

CPC classification number: C07D409/06 ,  C07D211/56 ,  C07D211/60 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/04

Abstract: The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.

Abstract translation: 本发明涉及一类新的杂环化合物及其药学上可接受的盐，其制备方法，含有这些化合物的药物组合物及其用于治疗由于AGEs的形成和积累引起的疾病（高级糖化终产物） 。 本发明的化合物可用于治疗由AGEs的形成和积累引起的糖尿病和老化相关并发症，例如神经病，肾病，微血管病变，视网膜病变，高血压，心力衰竭，动脉粥样硬化，阿尔茨海默病和皮肤病。

公开(公告)号：US20110130414A1

公开(公告)日：2011-06-02

申请号：US12877704

申请日：2010-09-08

Applicant: Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

Inventor： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC: A61K31/519 ,  C07D487/04 ,  C07D471/14 ,  A61P9/00 ,  A61P13/12 ,  A61P31/00 ,  A61P35/00 ,  A61P7/06

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Abstract translation: 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US08541430B2

公开(公告)日：2013-09-24

申请号：US12877704

申请日：2010-09-08

Applicant: Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

Inventor： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC: A01N43/54 ,  A61K31/505

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Abstract translation: 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US20100190824A1

公开(公告)日：2010-07-29

申请号：US12452389

申请日：2008-06-24

Applicant: Prabhat Kumar ,  Anookh Mohanan ,  Navnath Argade ,  Chakradhar Hadole ,  Appaji Mandhare ,  Ramesh Gupta ,  Shailesh Deshpande ,  Prashant Jamadarkhana ,  Poonam Joshi

Inventor： Prabhat Kumar ,  Anookh Mohanan ,  Navnath Argade ,  Chakradhar Hadole ,  Appaji Mandhare ,  Ramesh Gupta ,  Shailesh Deshpande ,  Prashant Jamadarkhana ,  Poonam Joshi

IPC: A61K31/4545 ,  C07D211/68 ,  A61P25/28 ,  A61P25/08 ,  A61P9/10

CPC classification number: C07D401/06 ,  C07D211/74 ,  C07D409/06 ,  C07D413/06

Abstract: The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Abstract translation: 本发明涉及式（I）或（II）的新化合物，其药学上可接受的盐及其水合物，溶剂合物，立体异构体，构象异构体，互变异构体，多晶型物和前药以及含有它们的药学上可接受的组合物。其中R1，R2，R3， R4，R5，R6和R7如说明书中所定义。 本发明的化合物是HSP诱导剂，并且由于这种效果，可用于治疗伴随病理应激的各种疾病。 本发明还涉及制备所述新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。