公开(公告)号：US09216956B2

公开(公告)日：2015-12-22

申请号：US14125666

申请日：2012-06-20

Applicant: Leif Svensson

Inventor： Leif Svensson

IPC: C07D215/00 ,  C07D215/56 ,  A61K31/4704

CPC classification number: C07D215/56 ,  A61K31/4704

Abstract: Deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoromethyl) -phenyl]-1,2-dihydroquinoline-3-carboxamide, having a deuterium enrichment in the amide-N methyl group of at least 70%; or a salt thereof with a pharmaceutically acceptable organic or inorganic cation; and a method of preparing said compounds. The compounds are useful in therapy, e.g. for the treatment of a malignant hyperproliferative disorder or an autoimmune disease.

Abstract translation: 富含氘的4-羟基-5-甲氧基-N，1-二甲基-2-氧代-N - [（4-三氟甲基） - 苯基] -1,2-二氢喹啉-3-甲酰胺在酰胺中具有氘浓缩 -N甲基至少70％; 或其盐与药学上可接受的有机或无机阳离子; 以及制备所述化合物的方法。 这些化合物可用于治疗，例如 用于治疗恶性过度增殖性疾病或自身免疫性疾病。

公开(公告)号：US20100029767A1

公开(公告)日：2010-02-04

申请号：US12535358

申请日：2009-08-04

Applicant: Helén Tuvesson Andersson ,  Ulf Vellmar ,  Ingrid Hallin ,  Leif Svensson ,  Ingela Fritzson

Inventor： Helén Tuvesson Andersson ,  Ulf Vellmar ,  Ingrid Hallin ,  Leif Svensson ,  Ingela Fritzson

IPC: A61K31/195 ,  C07C233/00 ,  A61P37/00 ,  A61P29/00

CPC classification number: C07C233/54 ,  C07C233/63 ,  C07C2601/02

Abstract: Compounds of formula (I) are provided, wherein X is CH═CH, CH2O wherein the oxygen atom is bound to ring B, or OCH2 wherein the oxygen atom is bound to ring A; Y is hydrogen, straight or branched C1-C6 alkyl or a pharmaceutically acceptable inorganic cation; R1 is ethyl or cyclopropyl; and R2 and R3 are the same or different and are selected from F, Cl, Br, CF3 and OCF3. The compounds are useful for the treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection, and malignant neoplasia. Pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods for preparing the compounds are also provided.

Abstract translation: 提供式（I）化合物，其中X为CH-CH，CH 2 O，其中氧原子与环B结合，或OCH 2，其中氧原子与环A结合; Y是氢，直链或支链C 1 -C 6烷基或药学上可接受的无机阳离子; R1是乙基或环丙基; R2和R3相同或不同，选自F，Cl，Br，CF 3和OCF 3。 该化合物可用于治疗自身免疫性疾病，炎性疾病，器官移植排斥反应和恶性肿瘤。 还提供了包含化合物的药物组合物，使用该化合物的方法和制备化合物的方法。

公开(公告)号：US4900819A

公开(公告)日：1990-02-13

申请号：US184131

申请日：1988-04-21

Applicant: Per Ericsson ,  Leif Svensson ,  Nils-Ingvar Olsson ,  Bertil Bergstrom

Inventor： Per Ericsson ,  Leif Svensson ,  Nils-Ingvar Olsson ,  Bertil Bergstrom

IPC: C06B21/00 ,  C06B25/34 ,  C07D251/06 ,  C07D257/02

CPC classification number: C07D257/02 ,  C06B21/0091 ,  C06B25/34 ,  C07D251/06

Abstract: The disclosure relates to a method of initiating a crystal growth prior to filtering off, from the mother liquor in which they were produced, of such crystalline explosives of the type hexogen and octogen produced by the so-called Bachmann process or variations of this process.According to the invention, the mother liquor is, after the end of the chemical reaction proper, subjected to a pressure-heat treatment which initiates the partial dissolution of the crystalline explosives obtained in the process, giving rise, after cooling of the mother liquor, to larger crystals which may more readily be filtered off.According to a further improvement of the invention a relatively pure octogen may be extracted from the mother liquor by way of a thermo-filtering of said liquor at a temperature of 60.degree.-110.degree. C.

公开(公告)号：US4718346A

公开(公告)日：1988-01-12

申请号：US876500

申请日：1986-06-20

Applicant: Hermann Schmid ,  Per Sjoberg ,  Leif Svensson

Inventor： Hermann Schmid ,  Per Sjoberg ,  Leif Svensson

IPC: B21D39/04 ,  B23K20/08 ,  C06B45/10 ,  F42B1/02

CPC classification number: B23K20/085 ,  B21D39/042 ,  C06B45/10

Abstract: The disclosure relates to an explosive charge intended for the explosive jointing of, primarily, large-diameter pipes, such as pipeline pipes. The charge according to the invention is intended to be delivered as a unit ready to be applied immediately on site in the pipe. The only item which is not intended to be included is the detonator which is mounted in place immediately prior to blowing the charge. The charge includes, apart from explosive, also a polymer binder of a more closely defined type and gas blisters preferably in the form of microspheres of glass or plastic and metal or metal oxide powder. The scope of the invention embraces the general configuration of the charge and all components included therein.

Abstract translation: 本公开涉及用于主要是大直径管道（例如管道管道）的爆炸接合的炸药。 根据本发明的电荷旨在作为准备在管道中的现场立即应用的单元递送。 不打算包括的唯一物品是在吹送费用之前立即安装的雷管。 除了爆炸物之外，电荷还包括更密切定义的类型的聚合物粘合剂和优选以玻璃或塑料的微球形式的金属或金属氧化物粉末的气泡。 本发明的范围包括电荷的一般结构及其中包含的所有组分。

公开(公告)号：US4638065A

公开(公告)日：1987-01-20

申请号：US716066

申请日：1985-03-26

Applicant: Leif Svensson ,  Jan-Olof Nyqvist ,  Lars Westling

Inventor： Leif Svensson ,  Jan-Olof Nyqvist ,  Lars Westling

IPC: C30B29/54 ,  C06B25/04 ,  C06B25/34 ,  C07D251/54 ,  C07D257/02 ,  C07D225/02

CPC classification number: C07D257/02 ,  C06B25/34 ,  C07D251/54

Abstract: The present invention relates to a method for the recrystallization of the high explosives HMX and RDX. According to the invention, the explosive is dissolved in a low molecular weight, liquid (at room temperature) lactone, after which the degree of saturation of the solution obtained, is changed by either lowering the temperature or by diluting with water.This method produces, depending on the crystallization method chosen, .beta.-HMX crystals or RDX crystals of either 50-1500 .mu.m or 5-50 .mu.m median particle diameter respectively.

Abstract translation: 本发明涉及高爆炸HMX和RDX的再结晶方法。 根据本发明，将爆炸物溶解在低分子量的液体（室温）内酯中，然后通过降低温度或通过用水稀释来改变所得溶液的饱和度。 该方法根据所选择的结晶方法产生分别为50-1500μm或5-50μm中值粒径的β-HMX晶体或RDX晶体。

公开(公告)号：US06484992B1

公开(公告)日：2002-11-26

申请号：US09674319

申请日：2000-10-25

Applicant: Leif Svensson ,  Mats Svensson

Inventor： Leif Svensson ,  Mats Svensson

IPC: A47H110

CPC classification number: G09F17/00

Abstract: An arrangement for a flag pole which exhibits, extending along the outside of the flag pole, a raisable holder for a flag, standard, banner or similar, whereby a line is so arranged and attached to the aforementioned flag holder as to run over a line deflector pulley situated at the top of the flag pole and down to the ground. The flag holder and a number of mast track slides and a counterweight are so arranged as to be guided by a guide extending in the longitudinal sense of the flag pole on the outside thereof, and a flag, etc., is so arranged as to be detachably attached to the aforementioned guided moving parts. In addition guide runners, which are pivotally mounted and capable of lateral movement to a certain extent, are attached to the flag holder.

Abstract translation: 旗杆的布置展现出沿着旗杆的外侧延伸的标志，标准，横幅或类似物的可升起的支架，由此将一条线排列并附着到上述标记支架上以便在一条线上行驶 偏转滑轮位于旗杆顶部并向下到地面。 旗杆支架和多个桅杆轨道滑块和配重被布置成由在其外侧的标志杆的纵向方向上延伸的引导件引导，并且标志等被布置为 可拆卸地附接到上述引导的运动部件。 此外，枢转地安装并能够在一定程度上横向移动的导向滑轮附接到标记保持器。

公开(公告)号：US4706567A

公开(公告)日：1987-11-17

申请号：US876446

申请日：1986-06-20

Applicant: Hermann Schmid ,  Per Sjoberg ,  Leif Svensson

Inventor： Hermann Schmid ,  Per Sjoberg ,  Leif Svensson

IPC: B21D39/04 ,  B23K20/08 ,  C06B45/10 ,  C06B45/12 ,  F42B3/00

CPC classification number: C06B45/10 ,  B21D39/042 ,  B23K20/085 ,  C06B45/12

Abstract: The disclosure relates to a method for producing charges for explosive jointing of large-diameter pipes such as pipelines. According to the invention, such charges are formed in that a strip-shaped flat explosive is wound and joined together to form a circular ring of even thickness consisting of a plurality of closely abutting layers.

Abstract translation: 本公开涉及一种用于生产诸如管道的大直径管道的爆炸接合的费用的方法。 根据本发明，这种电荷形成为一条带状扁平炸药被卷绕并接合在一起，以形成由多个紧密邻接的层组成的均匀厚度的圆环。