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公开(公告)号：US07322927B2
公开(公告)日：2008-01-29
申请号：US11448613
申请日：2006-06-06
IPC分类号： C40B30/04
CPC分类号： G01N33/54346 , C07F7/025 , G01N33/533 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak, and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求保护具有（1）具有所需激发峰的至少一个供体亚基，和（2）至少一个具有期望发射峰的受体亚单位 ，其中所述衍生物能够从所述供体亚单位转移到所述受体亚单位的分子内能量。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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公开(公告)号：US20060228748A1
公开(公告)日：2006-10-12
申请号：US11448613
申请日：2006-06-06
申请人： Kenneth Buechler , Joseph Noar , Lema Tadesse
发明人： Kenneth Buechler , Joseph Noar , Lema Tadesse
IPC分类号： C12Q1/68 , C07F7/02 , G01N33/551
CPC分类号： G01N33/54346 , C07F7/025 , G01N33/533 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak, and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求保护具有（1）具有所需激发峰的至少一个供体亚基，和（2）至少一个具有期望发射峰的受体亚单位 ，其中所述衍生物能够从所述供体亚单位转移到所述受体亚单位的分子内能量。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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公开(公告)号：US06964844B1
公开(公告)日：2005-11-15
申请号：US09066255
申请日：1998-04-24
IPC分类号： C07D487/22 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/533 , G01N33/542
CPC分类号： G01N33/533 , C07D487/22 , G01N33/542 , Y10T436/145555
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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4.发明授权Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds 失效使用新型化合物的荧光能量转移和颗粒中的分子内能量转移公开(公告)号：US06251687B1
公开(公告)日：2001-06-26
申请号：US08409298
申请日：1995-03-23
IPC分类号： G01N33543
CPC分类号： G01N33/587 , C09B47/08 , C09B67/0097 , G01N33/582 , Y10S436/80
摘要： The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles.
摘要翻译： 本发明描述了包含能量供体作为第一组分的颗粒和作为第二组分的荧光染料，其以彼此之间的能量交换距离定位在所述颗粒中，其中所述两种组分具有大于或等于50nm的斯托克斯位移 所述颗粒在其表面上结合了蛋白质，多肽，核酸，核苷酸或蛋白质的配体类似物。 此外，描述了新的荧光染料，其表现出分子内的能量转移用于标记各种分子，蛋白质，多肽，核苷酸和核酸或掺入到颗粒中。
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公开(公告)号：US06238931B1
公开(公告)日：2001-05-29
申请号：US08274534
申请日：1994-07-12
IPC分类号： G01N33533
CPC分类号： G01N33/587 , C09B47/08 , C09B67/0097 , G01N33/582 , Y10S436/80 , Y10S530/811 , Y10S530/812 , Y10S530/815 , Y10T428/2989 , Y10T428/2998
摘要： Particles and methods for the detection or visualization of analytes using fluorescence energy transfer. Particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed.
摘要翻译： 使用荧光能量转移检测或可视化分析物的粒子和方法。 包含作为第一成分的能量给体的粒子和以彼此间的能量交换距离定位在所述粒子中的第二成分的荧光染料，其中所述两种成分具有大于或等于50nm的斯托克斯位移，所述粒子具有 结合其表面，蛋白质，多肽，核酸，核苷酸或蛋白质的配体类似物被公开和要求保护。
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6.发明授权Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds 失效使用新型化合物的荧光能量转移和颗粒中的分子内能量转移
公开(公告)号：US5763189A
公开(公告)日：1998-06-09
申请号：US311098
申请日：1994-09-23
申请人： Kenneth F. Buechler , J. Barry Noar , Lema Tadesse
发明人： Kenneth F. Buechler , J. Barry Noar , Lema Tadesse
IPC分类号： G01N33/543 , A61K49/00 , C07D487/22 , C07F7/10 , C07K14/00 , C09B47/04 , C09B47/08 , C09B67/02 , C09K11/06 , G01N33/58 , G01N33/542 , C09K9/00 , C09K9/02
CPC分类号： G01N33/587 , C09B47/08 , C09B67/0097 , G01N33/582 , Y10S436/80 , Y10S530/811 , Y10S530/812 , Y10S530/815 , Y10T428/2989 , Y10T428/2998
摘要： Particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles.
摘要翻译： 包含作为第一成分的能量给体的粒子和以彼此间的能量交换距离定位在所述粒子中的第二成分的荧光染料，其中所述两种成分具有大于或等于50nm的斯托克斯位移，所述粒子具有 结合其表面，蛋白质，多肽，核酸，核苷酸或蛋白质的配体类似物被公开和要求保护。 此外，描述了新的荧光染料，其表现出分子内的能量转移用于标记各种分子，蛋白质，多肽，核苷酸和核酸或掺入到颗粒中。
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公开(公告)号：US07083984B2
公开(公告)日：2006-08-01
申请号：US09776599
申请日：2001-02-01
IPC分类号： G01N33/543
CPC分类号： G01N33/587 , C07D487/22 , C07F7/0838 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/76 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
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公开(公告)号：US5824799A
公开(公告)日：1998-10-20
申请号：US620597
申请日：1996-03-22
IPC分类号： C07D487/22 , C07F7/08 , C09B47/04 , C09B47/08 , C09B67/02 , G01N33/533 , G01N33/58 , G01N33/76 , C09B47/00 , C09B47/30
CPC分类号： C07D487/22 , C07F7/0863 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/585 , G01N33/76
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogs, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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