公开(公告)号：US5484778A

公开(公告)日：1996-01-16

申请号：US116259

申请日：1993-09-02

Applicant: Malcolm E. Kenney ,  Nancy L. Oleinick ,  Boris D. Rihter ,  Ying-Syi Li

Inventor： Malcolm E. Kenney ,  Nancy L. Oleinick ,  Boris D. Rihter ,  Ying-Syi Li

IPC: A61K31/695 ,  A61K31/40 ,  A61K41/00 ,  A61P35/00 ,  C07F7/08 ,  C09B47/04 ,  C09B47/08 ,  C09B47/32 ,  A61K31/555 ,  A61K31/685

CPC classification number: C07F7/0836 ,  A61K31/40 ,  A61K41/0057 ,  C07F7/0858 ,  C07F7/0863 ,  C09B47/045 ,  C09B47/08 ,  C09B47/32

Abstract: The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) germanium (Ge), gallium (Ga), tin (Sn) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.

Abstract translation: 本发明涉及一系列适用于光动力疗法的光敏剂的新型酞菁组合物（或化合物）。 具体地，本发明涉及一系列具有附着到中心金属的取代的胺或季铵轴配体的一系列新的铝（Al）锗（Ge），镓（Ga），锡（Sn）和/或硅（Si）酞菁， 以及这些新的酞菁组合物用于通过光敏化治疗癌症的用途。 此外，本发明涉及制备用于光动力疗法的这些组合物的方法。

公开(公告)号：US5576109A

公开(公告)日：1996-11-19

申请号：US425037

申请日：1995-04-18

Applicant: Takashige Yoneda ,  Takeshi Morimoto ,  Fumiaki Gunji ,  Kenji Ishizeki ,  Yukiko Ono

Inventor： Takashige Yoneda ,  Takeshi Morimoto ,  Fumiaki Gunji ,  Kenji Ishizeki ,  Yukiko Ono

IPC: B05D7/00 ,  C03C17/30 ,  C07F7/08 ,  C08G18/77 ,  C09D4/00 ,  B32B25/20

CPC classification number: B05D7/54 ,  C03C17/30 ,  C07F7/0863 ,  C08G18/778 ,  C09D4/00 ,  Y10T428/31663

Abstract: A surface treating agent containing a silicone compound of the formula (A):(R.sup.1).sub.a (R.sup.2).sub.b (Z.sup.1).sub.3-a-b SiO--[Si(R.sup.3).sub.c (R.sup.4).sub.d (Z.sup.2).sub.2-c-d O].sub.n --Si(R.sup.5).sub.e (R.sup.6).sub.f (Z.sup.3).sub.3-e-f (A)wherein each of R.sup.1 to R.sup.6 which are independent of one another, is a hydrogen atom or an organic group, provided that at least one of R.sup.1 to R.sup.6 is an organic group;each of Z.sup.1 to Z.sup.3 which are independent of one another, is an isocyanate group or a hydrolyzable group;each of a to f which are independent of one another, is an integer of 0, 1 or 2, provided l.ltoreq.a+b.ltoreq.3, 0.ltoreq.c+d.ltoreq.2, l.ltoreq.e+f.ltoreq.3 and 2.ltoreq.a+b+c+d+e+f.ltoreq.7; andn is an integer of 0 or at least 1.

Abstract translation: 含有式（A）的硅氧烷化合物的表面处理剂:( R1）a（R2）b（Z1）3-a-bSiO- [Si（R3）c（R4）d（Z2）2-c-dO ] n-Si（R 5）e（R 6）f（Z 3）3-ef（A）其中彼此独立的R 1至R 6中的每一个为氢原子或有机基团，条件是R 1至R 6中的至少一个 R6是有机基团; 彼此独立的Z 1至Z 3各自为异氰酸酯基或可水解基; 每个a至f彼此独立，为0,1或2的整数，条件是：a = a + b 3 = 0，c + d 2 / = e + f

公开(公告)号：US5484778C1

公开(公告)日：2001-05-08

申请号：US11625993

申请日：1993-09-02

Applicant: UNIV CLEVELAND HOSPITALS

Inventor： LI YING-SYI KENNEY MALCOLM E R ,  OLEINICK NANCY L

IPC: A61K31/695 ,  A61K31/40 ,  A61K41/00 ,  A61P35/00 ,  C07F7/08 ,  C09B47/04 ,  C09B47/08 ,  C09B47/32 ,  A61K31/555 ,  A61K31/685

CPC classification number: C07F7/0836 ,  A61K31/40 ,  A61K41/0057 ,  C07F7/0858 ,  C07F7/0863 ,  C09B47/045 ,  C09B47/08 ,  C09B47/32

Abstract: The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) germanium (Ge), gallium (Ga), tin (Sn) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.

公开(公告)号：US5824799A

公开(公告)日：1998-10-20

申请号：US620597

申请日：1996-03-22

Applicant: Kenneth F. Buechler ,  Joseph B. Noar ,  Lema Tadesse

Inventor： Kenneth F. Buechler ,  Joseph B. Noar ,  Lema Tadesse

IPC: C07D487/22 ,  C07F7/08 ,  C09B47/04 ,  C09B47/08 ,  C09B67/02 ,  G01N33/533 ,  G01N33/58 ,  G01N33/76 ,  C09B47/00 ,  C09B47/30

CPC classification number: C07D487/22 ,  C07F7/0863 ,  C09B47/045 ,  C09B47/08 ,  C09B67/0097 ,  G01N33/533 ,  G01N33/582 ,  G01N33/585 ,  G01N33/76

Abstract: Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogs, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.

Abstract translation: 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。