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公开(公告)号：US07322927B2
公开(公告)日：2008-01-29
申请号：US11448613
申请日：2006-06-06
IPC分类号： C40B30/04
CPC分类号： G01N33/54346 , C07F7/025 , G01N33/533 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak, and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求保护具有（1）具有所需激发峰的至少一个供体亚基，和（2）至少一个具有期望发射峰的受体亚单位 ，其中所述衍生物能够从所述供体亚单位转移到所述受体亚单位的分子内能量。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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公开(公告)号：US06964844B1
公开(公告)日：2005-11-15
申请号：US09066255
申请日：1998-04-24
IPC分类号： C07D487/22 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/533 , G01N33/542
CPC分类号： G01N33/533 , C07D487/22 , G01N33/542 , Y10T436/145555
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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公开(公告)号：US07083984B2
公开(公告)日：2006-08-01
申请号：US09776599
申请日：2001-02-01
IPC分类号： G01N33/543
CPC分类号： G01N33/587 , C07D487/22 , C07F7/0838 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/76 , Y10S436/80
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
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公开(公告)号：US5824799A
公开(公告)日：1998-10-20
申请号：US620597
申请日：1996-03-22
IPC分类号： C07D487/22 , C07F7/08 , C09B47/04 , C09B47/08 , C09B67/02 , G01N33/533 , G01N33/58 , G01N33/76 , C09B47/00 , C09B47/30
CPC分类号： C07D487/22 , C07F7/0863 , C09B47/045 , C09B47/08 , C09B67/0097 , G01N33/533 , G01N33/582 , G01N33/585 , G01N33/76
摘要： Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogs, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
摘要翻译： 在竞争性和非竞争性测定中有用的水溶性杂合酞菁衍生物公开和要求具有（1）具有所需激发峰的至少一个供体亚基; 和（2）具有所需发射峰的至少一个受体亚基，其中所述衍生物能够从所述供体亚基到所述受体亚基的分子内能量转移。 这样的衍生物也可以含有电子转移子单元。 轴向配体可以与水溶性杂合酞菁衍生物中所含的金属共价结合。 配体，配体类似物，多肽，蛋白质和核酸可以连接到染料的轴向配体上，以形成可用于免疫测定和核酸测定的染料缀合物。
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公开(公告)号：US5302715A
公开(公告)日：1994-04-12
申请号：US864093
申请日：1992-04-06
IPC分类号： A61K38/00 , A61K39/385 , A61K39/42 , A61K47/48 , C07D243/24 , C07D403/12 , C07D409/12 , C07K5/078 , C07K5/097 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/44 , G01N33/94 , A61K31/55
CPC分类号： C07D403/12 , A61K47/4833 , C07D243/24 , C07D409/12 , C07K14/705 , C07K16/00 , C07K16/44 , C07K5/06139 , C07K5/0821 , G01N33/948 , A61K38/00
摘要： The present invention is directed to novel benzodiazepine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the benzodiazepine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译： 本发明涉及用于共价连接到抗原（蛋白质或多肽）上用于制备苯二氮卓代谢物的抗体或受体的新型苯并二氮杂衍生物。 所得的新抗原可以用于使用标准方法生产抗体或受体。 一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。
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6.发明授权Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels 失效安非他明衍生物和蛋白质和多肽苯丙胺衍生物缀合物和标签
公开(公告)号：US5470997A
公开(公告)日：1995-11-28
申请号：US864108
申请日：1992-04-06
申请人： Kenneth F. Buechler , Joseph B. Noar , Si S. Moi
发明人： Kenneth F. Buechler , Joseph B. Noar , Si S. Moi
IPC分类号： A61K39/385 , C07C271/14 , C07C323/10 , C07C323/23 , C07C323/25 , C07C323/50 , C07C323/60 , C07C327/20 , C07C327/30 , C07C327/32 , C07K1/113 , C07K14/00 , C07K14/705 , C07K16/00 , C07C327/22 , C07C323/41 , C07C323/52
CPC分类号： C07C323/25 , C07C271/14 , C07C323/60 , C07C327/30 , C07C327/32
摘要： The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
摘要翻译： 本发明涉及新颖的苯丙胺衍生物，其被合成用于与抗原（蛋白质或多肽）的共价连接，用于制备苯丙胺和苯丙胺代谢物的抗体或受体。 所得的新抗原可以用于使用标准方法生产抗体或受体。 一旦产生，共价连接到蛋白质，多肽或标记的抗体或受体和新型衍生物可用于免疫测定过程。
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