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公开(公告)号：US20240108706A1
公开(公告)日：2024-04-04
申请号：US18528012
申请日：2023-12-04
申请人： LENTIGEN TECHNOLOGY, INC. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/28
CPC分类号： A61K39/001113 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/2803 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed.
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公开(公告)号：US11708408B2
公开(公告)日：2023-07-25
申请号：US16707505
申请日：2019-12-09
申请人： LENTIGEN TECHNOLOGY, INC. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/28 , A61P35/00 , C07K14/705 , C07K14/725 , A61K35/17 , C12N5/0783 , A61K39/00 , A61K35/12
CPC分类号： C07K16/2803 , A61K35/17 , A61K39/0011 , A61K39/001112 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70596 , C12N5/0636 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/035 , C07K2319/30 , C07K2319/33 , C12N2501/599 , C12N2510/00
摘要： Chimeric antigen receptors containing human CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US20210361709A1
公开(公告)日：2021-11-25
申请号：US17337018
申请日：2021-06-02
IPC分类号： A61K35/17 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/28
摘要： Chimeric antigen receptors containing BCMA antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US11103533B2
公开(公告)日：2021-08-31
申请号：US16698186
申请日：2019-11-27
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
摘要： Chimeric antigen receptors containing CD38 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US11045497B2
公开(公告)日：2021-06-29
申请号：US16698186
申请日：2019-11-27
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
摘要： Chimeric antigen receptors containing CD38 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US20200231648A1
公开(公告)日：2020-07-23
申请号：US16692957
申请日：2019-11-22
IPC分类号： C07K14/725 , C07K14/705 , C07K16/28 , A61P35/02 , A61K39/00 , A61K35/17 , C12N15/85
摘要： Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.
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公开(公告)号：US10550179B2
公开(公告)日：2020-02-04
申请号：US16252158
申请日：2019-01-18
申请人： Lentigen Technology Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C12N15/62 , C12N15/63 , C12N15/09 , C12N15/10 , C12N5/0783 , C07K16/28 , C07K16/30 , C07K14/705 , C07K14/725 , A61K35/17 , A61K39/395 , C07K16/18 , A61P35/02 , A61P35/00
摘要： Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US10426797B2
公开(公告)日：2019-10-01
申请号：US15934770
申请日：2018-03-23
申请人： Lentigen Technology, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K39/00 , C12Q1/6876 , C12N15/86 , A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28 , A61P35/02 , A61K39/395 , A61K48/00
摘要： Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US20180355052A1
公开(公告)日：2018-12-13
申请号：US16050754
申请日：2018-07-31
发明人： Rimas J. Orentas , Boro Dropulic , Dina Schneider
IPC分类号： C07K16/28 , C07K14/705 , A61P35/02 , A61K35/17 , C07K14/725
CPC分类号： C07K16/2887 , A61K35/17 , A61P35/02 , C07K14/705 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
摘要： Chimeric antigen receptors containing CD19/CD20 or CD20/CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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10.发明公开公开(公告)号：US20240307448A1
公开(公告)日：2024-09-19
申请号：US18624207
申请日：2024-04-02
IPC分类号： A61K35/17 , C07K14/705 , C07K14/725 , C07K16/28
CPC分类号： A61K35/17 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/2803 , C07K2317/622 , C07K2319/03
摘要： Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.
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