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公开(公告)号:US20100204642A1
公开(公告)日:2010-08-12
申请号:US12762254
申请日:2010-04-16
申请人: RICHARD R. WILSON , ROBERT L. WILCOX , CURTIS GENSTLER , TIM ABRAHAMSON , WM. GERRIT BARRERE , AMY COHEN , GEORGE KEILMAN , LEONARD R. OLIVER , NATALYA PESKIN
发明人: RICHARD R. WILSON , ROBERT L. WILCOX , CURTIS GENSTLER , TIM ABRAHAMSON , WM. GERRIT BARRERE , AMY COHEN , GEORGE KEILMAN , LEONARD R. OLIVER , NATALYA PESKIN
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The method comprises providing a catheter with a plurality of ultrasound radiating members, wherein the plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. The method further comprises independently driving each group of ultrasonic radiating members, and delivering the therapeutic compound through the catheter to the treatment site.
摘要翻译: 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 该方法包括提供具有多个超声辐射构件的导管,其中多个超声辐射构件被分配成包括多于一个超声波辐射构件的电组。 该方法还包括独立地驱动每组超声辐射构件,并将治疗化合物通过导管输送到治疗部位。
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公开(公告)号:US07774933B2
公开(公告)日:2010-08-17
申请号:US11417384
申请日:2006-05-04
CPC分类号: A61B17/2202 , A61B8/12 , A61B17/22 , A61B2017/00084 , A61B2017/22021 , A61B2017/22082 , A61B2017/22088 , B29C63/42 , Y10T29/49007 , Y10T29/49117 , Y10T29/49169 , Y10T29/49826
摘要: An ultrasonic catheter is manufactured by providing an inner tube having an inner diameter sufficient to accommodate a guidewire, and mounting a tubular ultrasound radiating member around a distal region of the inner tube. Two electrical conductors are positioned along the inner tube, such that one of the electrical conductors contacts an inner side of the ultrasound radiating member while the other electrical conductor contacts an outer side of the ultrasound radiating member. An outer tube is then concentrically translated over the inner tube and the ultrasound radiating member, and radially shrunken onto the inner tube.
摘要翻译: 通过提供具有足以容纳导丝的内径的内管并且围绕内管的远侧区域安装管状超声波辐射构件来制造超声波导管。 两个电导体沿着内管定位,使得一个电导体接触超声波辐射构件的内侧,而另一个电导体接触超声波辐射构件的外侧。 然后将外管在内管和超声波辐射构件上同心地平移,并且径向缩小到内管上。
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公开(公告)号:US07727178B2
公开(公告)日:2010-06-01
申请号:US11643471
申请日:2006-12-21
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号: A61B17/20
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.
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公开(公告)号:US08167831B2
公开(公告)日:2012-05-01
申请号:US12762254
申请日:2010-04-16
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号: A61B17/20
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The method comprises providing a catheter with a plurality of ultrasound radiating members, wherein the plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. The method further comprises independently driving each group of ultrasonic radiating members, and delivering the therapeutic compound through the catheter to the treatment site.
摘要翻译: 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 该方法包括提供具有多个超声辐射构件的导管,其中多个超声辐射构件被分配成包括多于一个超声波辐射构件的电组。 该方法还包括独立地驱动每组超声辐射构件,并将治疗化合物通过导管输送到治疗部位。
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公开(公告)号:US07220239B2
公开(公告)日:2007-05-22
申请号:US10309388
申请日:2002-12-03
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号: A61B17/20
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.
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公开(公告)号:US06958040B2
公开(公告)日:2005-10-25
申请号:US10331439
申请日:2002-12-27
IPC分类号: A61B8/00 , A61B8/14 , A61B17/22 , A61M20060101 , A61N7/00
CPC分类号: A61B17/2202 , A61B2017/22021 , A61B2017/22028 , A61B2017/22082
摘要: A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end. The catheter system further comprises an inner core configured for insertion into the tubular body. The inner core has an outer surface and comprises an electrically conductive core material. The catheter system further comprises a plurality of ultrasound radiating members positioned on the outer surface of the inner core. The ultrasound radiating members are electrically connected to the electrically conductive core material. The catheter system further comprises an electrically conductive tube-shaped member disposed over the inner core and over the ultrasound radiating members positioned thereon. At least a portion of the electrically conductive tube-shaped member is electrically connected to a plurality of the ultrasound radiating members. The catheter system further comprises control circuitry configured to deliver an input signal to a plurality of the ultrasound radiating members.
摘要翻译: 用于将超声能量和治疗性化合物输送到患者脉管系统内的治疗部位的导管系统包括管状体。 管状体具有近端,远端和位于近端和远端之间的能量输送部分。 该导管系统还包括被配置成插入到管状体内的内芯。 内芯具有外表面并且包括导电芯材料。 导管系统还包括定位在内芯的外表面上的多个超声辐射构件。 超声波辐射构件电连接到导电芯材料。 导管系统还包括设置在内芯上并位于其上的超声辐射构件之上的导电管状构件。 导电管状构件的至少一部分电连接到多个超声波辐射构件。 导管系统还包括配置成将输入信号传送到多个超声波辐射构件的控制电路。
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公开(公告)号:US20100331763A1
公开(公告)日:2010-12-30
申请号:US12846744
申请日:2010-07-29
CPC分类号: A61B17/2202 , A61B8/12 , A61B17/22 , A61B2017/00084 , A61B2017/22021 , A61B2017/22082 , A61B2017/22088 , B29C63/42 , Y10T29/49007 , Y10T29/49117 , Y10T29/49169 , Y10T29/49826
摘要: An ultrasound catheter comprises an elongate tubular body is disclosed. The elongate tubular body has a proximal region and a distal region opposite the proximal region. The tubular body defines a central lumen having a central lumen surface that is electrically conductive. The ultrasound catheter further comprises an elongate, hollow inner core extending through the central lumen and has an inner core outer surface that is electrically conductive. The ultrasound catheter further comprises an ultrasound radiating member positioned within the distal region of the tubular body and between the tubular body and the inner core, such that the tubular body conductive surface and the inner core conductive surface are both in electrical contact with the ultrasound radiating member. The ultrasound catheter further comprises an insulating sleeve positioned between the tubular body and the inner core in a region proximal to the ultrasound radiating member.
摘要翻译: 公开了一种包括细长管状体的超声导管。 细长管状体具有近端区域和与近端区域相对的远端区域。 管状体限定具有导电性的中心管腔表面的中心管腔。 超声导管还包括延伸穿过中心腔并且具有导电的内芯外表面的细长的中空内芯。 超声波导管进一步包括超声辐射构件,该超声波辐射构件位于管体的远侧区域内并且在管状主体和内芯之间,使得管状体导电表面和内芯导电表面都与超声波辐射电接触 会员。 所述超声导管还包括位于所述管体和所述内芯之间的绝缘套管,所述绝缘套管邻近所述超声辐射构件。
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公开(公告)号:US07828762B2
公开(公告)日:2010-11-09
申请号:US11643417
申请日:2006-12-21
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号: A61B17/20
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.
摘要翻译: 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体,每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧,并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。
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公开(公告)号:US08696612B2
公开(公告)日:2014-04-15
申请号:US13431798
申请日:2012-03-27
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号: A61M25/00
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.
摘要翻译: 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体,其具有位于远端和近端之间的近端,远端和处理区,流体输送腔,位于治疗区中的至少一个超声波辐射元件,电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器,以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒,所述隔离盒位于所述管状 主体和外部系统,并且包括用于驱动超声波辐射元件的隔离屏障和电路。
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公开(公告)号:US20120253237A1
公开(公告)日:2012-10-04
申请号:US13431798
申请日:2012-03-27
申请人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人: Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
CPC分类号: A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要: A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.
摘要翻译: 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体,其具有位于远端和近端之间的近端,远端和处理区,流体输送腔,位于治疗区中的至少一个超声波辐射元件,电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器,以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒,所述隔离盒位于所述管状 主体和外部系统,并且包括用于驱动超声波辐射元件的隔离屏障和电路。
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