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公开(公告)号：US20060009425A1
公开(公告)日：2006-01-12
申请号：US11137611
申请日：2005-05-25
IPC分类号： A61K31/59
CPC分类号： A61K31/59
摘要： The present invention relates to oral formulations comprising paricalcitol that are available in a variety of different dosage forms that are bioequivalent to one another.
摘要翻译： 本发明涉及包含帕立骨化醇的口服制剂，其可以以彼此生物等效的各种不同剂型获得。
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2.发明申请公开(公告)号：US20050261256A1
公开(公告)日：2005-11-24
申请号：US11191196
申请日：2005-07-27
IPC分类号： A61K31/593 , A61K31/59 , A61K31/592 , A61P3/02 , A61P19/00
CPC分类号： A61K31/593 , A61K31/59 , A61K31/592
摘要： The present invention relates to a method of improving intensive care unit (ICU)-associated hypocalcemia in a mammal by the administration of a vitamin D compound, or other compounds exhibiting vitamin D-like activity, to the mammal for a sufficient period of time to improve or restore the serum calcium levels of the mammal.
摘要翻译： 本发明涉及通过向哺乳动物施用维生素D化合物或其他具有维生素D样活性的化合物足够长的时间来改善哺乳动物中重症监护病房（ICU）相关低钙血症的方法， 改善或恢复哺乳动物的血清钙水平。
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公开(公告)号：US20120208899A1
公开(公告)日：2012-08-16
申请号：US13274040
申请日：2011-10-14
申请人： Leticia Delgado-Herrera , Abhijit Barve , Kathryn Lasch , Allam Fakhoury , Smita Kothari , Akito Nishida , Patrick Marquis , Glen Spears , Bernhardt G. Zeiher , Kathleen Rees Rosa , Laura Tesler Waldman
发明人： Leticia Delgado-Herrera , Abhijit Barve , Kathryn Lasch , Allam Fakhoury , Smita Kothari , Akito Nishida , Patrick Marquis , Glen Spears , Bernhardt G. Zeiher , Kathleen Rees Rosa , Laura Tesler Waldman
CPC分类号： G06F19/3456 , A61B5/4255 , A61B5/4842 , A61B5/7475 , G16H10/20
摘要： Methods of treating and/or diagnosing irritable bowel syndrome (IBS) are provided, wherein treatment or diagnosis is undertaken on the basis of the patient's recordation of events associated with IBS in an event log and/or symptom diary.
摘要翻译： 提供治疗和/或诊断肠易激综合征（IBS）的方法，其中根据患者在事件日志和/或症状日志中与IBS相关的事件的记录进行治疗或诊断。
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公开(公告)号：US20080077025A1
公开(公告)日：2008-03-27
申请号：US11456741
申请日：2006-07-11
申请人： Leticia Delgado-Herrera , Robert J. Padley , Jeffrey E. Salon , Roopal B. Thakkar , Bidan Huang
发明人： Leticia Delgado-Herrera , Robert J. Padley , Jeffrey E. Salon , Roopal B. Thakkar , Bidan Huang
CPC分类号： A61B5/021 , A61K31/50 , G06Q30/0217 , G06Q50/22
摘要： The present invention relates to methods for determining how to treat congestive heart failure.
摘要翻译： 本发明涉及确定如何治疗充血性心力衰竭的方法。
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公开(公告)号：US20080070917A1
公开(公告)日：2008-03-20
申请号：US11741066
申请日：2007-04-27
申请人： Roopal Thakkar , Leticia Delgado-Herrera , Rajendra Pradhan , Peter Noertersheuser , Walid Awni , Wenhui Zhang
发明人： Roopal Thakkar , Leticia Delgado-Herrera , Rajendra Pradhan , Peter Noertersheuser , Walid Awni , Wenhui Zhang
CPC分类号： A61K31/50
摘要： The invention relates to a method of administering an inotropic agent (such as, but not limited to, a levosimendan compound) or a pharmaceutically acceptable salt thereof in the treatment of cardiovascular disorders.
摘要翻译： 本发明涉及在治疗心血管疾病中施用变力剂（例如但不限于，左西孟旦化合物）或其药学上可接受的盐的方法。
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公开(公告)号：US20070032557A1
公开(公告)日：2007-02-08
申请号：US11355897
申请日：2006-02-17
IPC分类号： A61K31/122
CPC分类号： A61K31/50 , A61K31/00 , A61K31/122
摘要： The invention relates to intermittent administration of an inotropic agent (such as, but not limited to a levosimendan compound) or a pharmaceutically acceptable salt thereof in the treatment of cardiovascular disorders, such as, pulmonary hypertension, myocardial ischemia, acute heart failure, chronic heart failure or acute on chronic heart failure.
摘要翻译： 本发明涉及在治疗心血管疾病如肺动脉高压，心肌缺血，急性心力衰竭，慢性心脏的间断给药中使用变力剂（例如但不限于左西孟旦化合物）或其药学上可接受的盐 失败或急性慢性心力衰竭。
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公开(公告)号：US20050148557A1
公开(公告)日：2005-07-07
申请号：US10901660
申请日：2004-07-28
IPC分类号： A61K9/00 , A61K9/70 , A61K31/401 , A61K31/59 , A61K31/592 , A61K31/593 , A61K45/06
CPC分类号： A61K31/401 , A61K9/0024 , A61K9/7023 , A61K31/59 , A61K31/592 , A61K31/593 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions containing a VDRA/Vitamin D analog to treat or prevent kidney disease, including chronic kidney disease. The present invention also relates to methods of treating kidney disease by administering to a patient a pharmaceutical composition containing a therapeutically effective amount of a VDRA/Vitamin D analog. Compositions according to the invention include a VDRA/Vitamin D analog and at least one of the following agents: an ACE inhibitor, an angiotensin (II) receptor blocker (ARB) and aldosterone blocker in therapeutically effective amounts to inhibit renin production or inhibit activation of the renin-angiotensin-aldosterone system. Preferred compositions contain paricalcitol with at least one of these other agents. Such combinations can avoid ACE inhibition escape and aldosterone escape with subsequent increase in angiotensin (II) and aldosterone generation.
摘要翻译： 公开了含有VDRA /维生素D类似物以治疗或预防肾脏疾病（包括慢性肾脏疾病）的组合物。 本发明还涉及通过向患者施用含有治疗有效量的VDRA /维生素D类似物的药物组合物来治疗肾脏疾病的方法。 根据本发明的组合物包括VDRA /维生素D类似物和至少一种以下药剂：ACE抑制剂，血管紧张素（II）受体阻断剂（ARB）和醛固酮阻滞剂，其治疗有效量抑制肾素的产生或抑制 肾素 - 血管紧张素 - 醛固酮系统。 优选的组合物含有与这些其它试剂中的至少一种的帕立骨化醇。 这样的组合可以避免ACE抑制逃避和醛固酮逃逸，随后随着血管紧张素（II）和醛固酮生成的增加。
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8.发明申请公开(公告)号：US20060293395A1
公开(公告)日：2006-12-28
申请号：US11139344
申请日：2005-05-27
申请人： Max Weil , Shije Sun , Wauchan Tang , Robert Padley , Leticia Delgado-Herrera
发明人： Max Weil , Shije Sun , Wauchan Tang , Robert Padley , Leticia Delgado-Herrera
IPC分类号： A61K31/122 , A61N1/00
CPC分类号： A61K31/50 , A61K31/122 , A61N1/39
摘要： Methods for treating mammals before, during and after cardiac arrest are disclosed. Pharmaceutical compositions comprising levosimendan useful for such treatment also are disclosed.
摘要翻译： 公开了在心脏骤停之前，期间和之后治疗哺乳动物的方法。 也公开了包含用于这种治疗的左西孟旦的药物组合物。
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公开(公告)号：US20050124591A1
公开(公告)日：2005-06-09
申请号：US10974243
申请日：2004-10-27
申请人： Jin Tian , Joel Melnick , Laura Williams , Leticia Delgado-Herrera , Ping Qiu
发明人： Jin Tian , Joel Melnick , Laura Williams , Leticia Delgado-Herrera , Ping Qiu
IPC分类号： A61K9/00 , A61K9/70 , A61K31/401 , A61K31/59 , A61K31/592 , A61K31/593 , A61K45/06
CPC分类号： A61K31/401 , A61K9/0024 , A61K9/7023 , A61K31/59 , A61K31/592 , A61K31/593 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions containing a VDRA/Vitamin D analog to treat or prevent kidney disease, including chronic kidney disease. The present invention also relates to methods of treating kidney disease by administering to a patient a pharmaceutical composition containing a therapeutically effective amount of a VDRA/Vitamin D analog. Compositions according to the invention include a VDRA/Vitamin D analog and at least one of the following agents: an ACE inhibitor, an angiotensin (II) receptor blocker (ARB) and aldosterone blocker in therapeutically effective amounts to inhibit renin production or inhibit activation of the renin-angiotensin-aldosterone system. Preferred compositions contain paricalcitol with at least one of these other agents. Such combinations can avoid ACE inhibition escape and aldosterone escape with subsequent increase in angiotensin (II) and aldosterone generation.
摘要翻译： 公开了含有VDRA /维生素D类似物以治疗或预防肾脏疾病（包括慢性肾脏疾病）的组合物。 本发明还涉及通过向患者施用含有治疗有效量的VDRA /维生素D类似物的药物组合物来治疗肾脏疾病的方法。 根据本发明的组合物包括VDRA /维生素D类似物和至少一种以下药剂：ACE抑制剂，血管紧张素（II）受体阻断剂（ARB）和醛固酮阻滞剂，其治疗有效量抑制肾素的产生或抑制 肾素 - 血管紧张素 - 醛固酮系统。 优选的组合物含有与这些其它试剂中的至少一种的帕立骨化醇。 这样的组合可以避免ACE抑制逃避和醛固酮逃逸，随后随着血管紧张素（II）和醛固酮生成的增加。
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