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公开(公告)号：US20090209482A1
公开(公告)日：2009-08-20
申请号：US12238125
申请日：2008-09-25
申请人： Lewis SILVERMAN , James HOLLAND
发明人： Lewis SILVERMAN , James HOLLAND
IPC分类号： A61K31/7068 , C07H19/12 , A61P35/00
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H or R5C(O), provided that R and R4 are not simultaneously H; and R5 is a C3-C26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译： 本发明涉及如下式（I）化合物：其中R为H，R 5 C（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H或R5C（O），条件是R和R4不同时为H; R5为C3-C26烯基或其药物盐。 还公开了制备和使用这些化合物的方法。
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公开(公告)号：US20090209477A1
公开(公告)日：2009-08-20
申请号：US12238054
申请日：2008-09-25
IPC分类号： A61K31/706 , C07H19/12 , A61P35/00 , A61P29/00
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译： 本发明涉及如下式（I）化合物：其中R是H，R 5 C（O），R 5 CH 2 OC（O）或R 5 CH 2 NHC（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H，R5C（O），R5CH2OC（O）或R5CH2NHC（O），条件是R和R4不同时为H; 并且R5具有以下通式：<？in-line-formula description =“In-line Formulas”end =“lead”？> CH3-（CH2）n-（CH-CH-CH2）m-CH-CH-（ CH 2）k - ; <？in-line-formula description =“In-line Formulas”end =“tail”？> k是0至7的整数; m为0〜2的整数; n为0〜10的整数，或其药学盐。 还公开了制备和使用这些化合物的方法。
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公开(公告)号：US08399420B2
公开(公告)日：2013-03-19
申请号：US12238054
申请日：2008-09-25
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译： 本发明涉及如下式（I）化合物：其中R是H，R 5 C（O），R 5 CH 2 OC（O）或R 5 CH 2 NHC（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H，R5C（O），R5CH2OC（O）或R5CH2NHC（O），条件是R和R4不同时为H; 并且R 5具有通式：CH 3 - （CH 2）n - （CH = CH-CH 2）m -CH = CH-（CH 2）k - ; k是0至7的整数; m为0〜2的整数; n为0〜10的整数，或其药学盐。 还公开了制备和使用这些化合物的方法。
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公开(公告)号：US08158605B2
公开(公告)日：2012-04-17
申请号：US12238125
申请日：2008-09-25
申请人： Lewis Silverman , James Holland
发明人： Lewis Silverman , James Holland
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H or R5C(O), provided that R and R4 are not simultaneously H; and R5 is a C3-C26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译： 本发明涉及如下式（I）化合物：其中R为H，R 5 C（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H或R5C（O），条件是R和R4不同时为H; R5为C3-C26烯基或其药物盐。 还公开了制备和使用这些化合物的方法。
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