利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.02 秒)

    Azacytidine analogues and uses thereof
    1.
    发明授权
    Azacytidine analogues and uses thereof 失效
    氮杂胞苷类似物及其用途

    公开(公告)号：US08399420B2

    公开(公告)日：2013-03-19

    申请号：US12238054

    申请日：2008-09-25

    申请人： Lewis Silverman ,  James Holland ,  Marit Liland Sandvold ,  Finn Myhren ,  Ole Henrik Eriksen

    发明人： Lewis Silverman ,  James Holland ,  Marit Liland Sandvold ,  Finn Myhren ,  Ole Henrik Eriksen

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07D405/14 ,  A61K31/53 ,  A61K31/706 ,  C07H19/12

    摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.

    摘要翻译： 本发明涉及如下式（I）化合物：其中R是H，R 5 C（O），R 5 CH 2 OC（O）或R 5 CH 2 NHC（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H，R5C（O），R5CH2OC（O）或R5CH2NHC（O），条件是R和R4不同时为H; 并且R 5具有通式：CH 3 - （CH 2）n - （CH = CH-CH 2）m -CH = CH-（CH 2）k - ; k是0至7的整数; m为0〜2的整数; n为0〜10的整数，或其药学盐。 还公开了制备和使用这些化合物的方法。

    Azacytidine analogues and uses thereof
    2.
    发明授权
    Azacytidine analogues and uses thereof 有权
    氮杂胞苷类似物及其用途

    公开(公告)号：US08158605B2

    公开(公告)日：2012-04-17

    申请号：US12238125

    申请日：2008-09-25

    申请人： Lewis Silverman ,  James Holland

    发明人： Lewis Silverman ,  James Holland

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07D405/14 ,  A61K31/53 ,  A61K31/706 ,  C07H19/12

    摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H or R5C(O), provided that R and R4 are not simultaneously H; and R5 is a C3-C26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.

    摘要翻译： 本发明涉及如下式（I）化合物：其中R为H，R 5 C（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H或R5C（O），条件是R和R4不同时为H; R5为C3-C26烯基或其药物盐。 还公开了制备和使用这些化合物的方法。

    AZACYTIDINE ANALOGUES AND USES THEREOF
    3.
    发明申请
    AZACYTIDINE ANALOGUES AND USES THEREOF 失效
    阿伐他汀类似物及其用途

    公开(公告)号：US20090209477A1

    公开(公告)日：2009-08-20

    申请号：US12238054

    申请日：2008-09-25

    申请人： Lewis Silverman ,  James Holland ,  Marit Liland Sandvold ,  Finn Myhren ,  Ole Henrik Eriksen

    发明人： Lewis Silverman ,  James Holland ,  Marit Liland Sandvold ,  Finn Myhren ,  Ole Henrik Eriksen

    IPC分类号： A61K31/706 ,  C07H19/12 ,  A61P35/00 ,  A61P29/00

    CPC分类号： C07D405/14 ,  A61K31/53 ,  A61K31/706 ,  C07H19/12

    摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.

    摘要翻译： 本发明涉及如下式（I）化合物：其中R是H，R 5 C（O），R 5 CH 2 OC（O）或R 5 CH 2 NHC（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H，R5C（O），R5CH2OC（O）或R5CH2NHC（O），条件是R和R4不同时为H; 并且R5具有以下通式：<？in-line-formula description =“In-line Formulas”end =“lead”？> CH3-（CH2）n-（CH-CH-CH2）m-CH-CH-（ CH 2）k - ; <？in-line-formula description =“In-line Formulas”end =“tail”？> k是0至7的整数; m为0〜2的整数; n为0〜10的整数，或其药学盐。 还公开了制备和使用这些化合物的方法。

    Method and system for managing account information
    4.
    发明申请
    Method and system for managing account information 有权
    用于管理帐户信息的方法和系统

    公开(公告)号：US20060204051A1

    公开(公告)日：2006-09-14

    申请号：US11373551

    申请日：2006-03-10

    申请人： James Holland

    发明人： James Holland

    IPC分类号： G06K9/00

    CPC分类号： G06Q20/02 ,  G06Q20/227 ,  G06Q20/40 ,  G06Q20/4014 ,  G06Q20/42 ,  G06Q20/425 ,  G06Q40/04 ,  G07C9/00039 ,  G07C9/00087

    摘要： A method and system for authenticating the identity of a consumer is disclosed. After the consumer is authenticated by a trusted third party, the consumer designates accounts that the consumer wishes to “lock.” When a party requests access to that account, the consumer is notified through the consumer's phone and asked to input a PIN. If the consumer provides the PIN, the requestor is granted access to the consumer's account without requiring further input from the consumer. If the party authorizing the transaction in this “two-factor” authentication does not possess both the phone and the consumer's PIN, or that party elects not to provide the PIN, the request will not be authenticated.

    摘要翻译： 公开了一种用于认证消费者身份的方法和系统。 在消费者被可靠的第三方认证之后，消费者指定消费者希望“锁定”的帐户。 当一方请求访问该帐户时，消费者将通过消费者的电话进行通知，并要求输入PIN。 如果消费者提供PIN，则请求者被授予访问消费者帐户的权限，而不需要消费者的进一步输入。 如果在“双因素”认证中授权交易的一方不具有电话和消费者的PIN，或者该方不选择提供PIN，则该请求将不被认证。

    NUCLEI DENSITY AND NUCLEI AREA METHODS FOR DETERMINING THE EFFECTS OF A BOTULINUM TOXIN ON MUSCLES
    7.
    发明申请
    NUCLEI DENSITY AND NUCLEI AREA METHODS FOR DETERMINING THE EFFECTS OF A BOTULINUM TOXIN ON MUSCLES 审中-公开
    核酸密度和核酸区域确定火鸡毒素对马铃薯的影响的方法

    公开(公告)号：US20070218005A1

    公开(公告)日：2007-09-20

    申请号：US11749427

    申请日：2007-05-16

    申请人： James Holland ,  Edward Chow

    发明人： James Holland ,  Edward Chow

    IPC分类号： A61K49/00

    CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

    摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.

    摘要翻译： 公开了确定梭菌神经毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。 这些方法可用于区分两种不同的梭菌神经毒素。 在某些实施方案中，神经毒素从肉毒杆菌获得。

    Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
    9.
    发明申请
    Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles 失效
    用于确定肉毒杆菌毒素对肌肉的影响的核密度和核区域方法

    公开(公告)号：US20050019338A1

    公开(公告)日：2005-01-27

    申请号：US10918845

    申请日：2004-08-13

    申请人： James Holland ,  Edward Chow

    发明人： James Holland ,  Edward Chow

    IPC分类号： G01N33/15 ,  A61K49/00 ,  A61K39/00 ,  A61K39/08 ,  A61K39/38

    CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

    摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.

    摘要翻译： 公开了确定梭菌神经毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。 这些方法可用于区分两种不同的梭菌神经毒素。 在某些实施方案中，神经毒素从肉毒杆菌获得。