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13 条记录 (耗时 0.029 秒)

    Polymorph and process for preparing same
    1.
    发明授权
    Polymorph and process for preparing same 有权
    多晶型物及其制备方法

    公开(公告)号：US06753426B2

    公开(公告)日：2004-06-22

    申请号：US10300448

    申请日：2002-11-20

    申请人： Lin-Hua Zhang ,  Lei Zhu

    发明人： Lin-Hua Zhang ,  Lei Zhu

    IPC分类号： C07D40512

    CPC分类号： C07D401/12 ,  C07D231/40 ,  C07D401/14 ,  C07D405/12

    摘要： Disclosed are processes, polymorph and intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

    摘要翻译： 公开了用于制备其中Ar1，Ar2，L，Q和X的式（I）的芳基和杂芳基取代的脲化合物的方法，多晶型物和中间体化合物。 产品化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。

    Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    2.
    发明授权
    Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents 有权
    用作抗炎剂的杂芳基取代的脲化合物的合成方法

    公开(公告)号：US06583282B1

    公开(公告)日：2003-06-24

    申请号：US09611109

    申请日：2000-07-06

    申请人： Lin-Hua Zhang ,  Lei Zhu

    发明人： Lin-Hua Zhang ,  Lei Zhu

    IPC分类号： C07D41312

    CPC分类号： C07D401/12 ,  C07D231/40 ,  C07D401/14 ,  C07D405/12

    摘要： Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

    摘要翻译： 公开了用于制备式（I）的芳基 - 和杂芳基取代的脲化合物的新方法和新型中间体化合物，其中Ar1，Ar2，L，Q和X在本文中描述。 产品化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。

    Intermediates for the synthesis of anthrapyrazolone anticancer agents
    4.
    发明授权
    Intermediates for the synthesis of anthrapyrazolone anticancer agents 失效
    蒽醌类抗癌药合成中间体

    公开(公告)号：US5393886A

    公开(公告)日：1995-02-28

    申请号：US142635

    申请日：1993-10-25

    申请人： Lin-Hua Zhang ,  Joseph Auerbach

    发明人： Lin-Hua Zhang ,  Joseph Auerbach

    IPC分类号： C07D231/54

    CPC分类号： C07D231/54

    摘要： This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

    摘要翻译： 本发明涉及化合物，包括5-氯-2- [2 - [[（4-甲基苯基）磺酰基]氧基]乙基] -7- [2,4,6-三甲基苯基）甲氧基]蒽[1,9-cd ]吡唑-6（2H） - 酮及其类似物，其可用作合成蒽唑酮抗癌剂的中间体，包括依索沙龙。 本发明还涉及合成蒽唑酮抗癌剂的方法，其包括依索沙龙。

    Polycyclo heterocyclic derivatives as antiinflammatory agents
    5.
    发明授权
    Polycyclo heterocyclic derivatives as antiinflammatory agents 有权
    多环杂环衍生物作为抗炎剂

    公开(公告)号：US06242453B1

    公开(公告)日：2001-06-05

    申请号：US09503263

    申请日：2000-02-14

    申请人： Pier F. Cirillo ,  Eugene R. Hickey ,  John R. Regan ,  Lin-Hua Zhang

    发明人： Pier F. Cirillo ,  Eugene R. Hickey ,  John R. Regan ,  Lin-Hua Zhang

    IPC分类号： C07D48704

    CPC分类号： C07D487/04 ,  A61K31/517

    摘要： Disclosed are novel aromatic polycyclo heterocyclic compounds of the formula(I) wherein A, B, C, G, Ar, L, Q and X are described herein. The compounds are useful in pharmaceutical compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes of making such compounds.

    摘要翻译： 公开了式（I）的新型芳族多环杂环化合物，其中A，B，C，G，Ar，L，Q和X如本文所述。 该化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。 还公开了制备这些化合物的方法。

    Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    8.
    发明授权
    Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents 有权
    用作抗炎剂的杂芳基取代的脲化合物的合成方法

    公开(公告)号：US06835832B2

    公开(公告)日：2004-12-28

    申请号：US10361731

    申请日：2003-02-10

    申请人： Lin-Hua Zhang ,  Lei Zhu

    发明人： Lin-Hua Zhang ,  Lei Zhu

    IPC分类号： C07D295135

    CPC分类号： C07D401/12 ,  C07D231/40 ,  C07D401/14 ,  C07D405/12

    摘要： Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

    摘要翻译： 公开了用于制备式（I）的芳基和杂芳基取代的脲化合物的新方法和新型中间体化合物，其中本文描述了Ar1，Ar2，L，Q和X。 产品化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。