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公开(公告)号：US20100080811A1
公开(公告)日：2010-04-01
申请号：US12611470
申请日：2009-11-03
申请人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
发明人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
IPC分类号： A61K39/395 , A61P21/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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公开(公告)号：US20090131638A1
公开(公告)日：2009-05-21
申请号：US12066838
申请日：2006-10-05
申请人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda Maureen O'Bryan (nee Tobias) , Rong Wang
发明人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda Maureen O'Bryan (nee Tobias) , Rong Wang
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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