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公开(公告)号：US20090131638A1
公开(公告)日：2009-05-21
申请号：US12066838
申请日：2006-10-05
申请人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda Maureen O'Bryan (nee Tobias) , Rong Wang
发明人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda Maureen O'Bryan (nee Tobias) , Rong Wang
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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公开(公告)号：US20090060924A1
公开(公告)日：2009-03-05
申请号：US12160472
申请日：2008-03-11
IPC分类号： A61K39/395 , C07K16/18 , A61P19/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US08257704B2
公开(公告)日：2012-09-04
申请号：US13165126
申请日：2011-06-21
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US07744874B2
公开(公告)日：2010-06-29
申请号：US12160472
申请日：2008-03-11
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US20100080811A1
公开(公告)日：2010-04-01
申请号：US12611470
申请日：2009-11-03
申请人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
发明人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
IPC分类号： A61K39/395 , A61P21/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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公开(公告)号：US20090252727A1
公开(公告)日：2009-10-08
申请号：US12405458
申请日：2009-03-17
IPC分类号： A61K39/395 , C07K16/00 , C12N15/63 , C12N5/00 , A61P3/10
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to glucagon receptor polypeptide antagonists which inhibit the binding of the hormone glucagon to its receptor. More particularly, the present invention relates to high affinity glucagon receptor antibodies or Fab fragments thereof that inhibit binding of glucagon to its receptor and their use in the treatment or prevention of type 2 diabetes (NIDDM) and related disorders in mammalian species.
摘要翻译： 本发明涉及抑制激素胰高血糖素与其受体结合的胰高血糖素受体多肽拮抗剂。 更具体地，本发明涉及抑制胰高血糖素与其受体的结合的高亲和力胰高血糖素受体抗体或其Fab片段及其在哺乳动物物种中治疗或预防2型糖尿病（NIDDM）和相关病症中的用途。
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公开(公告)号：US08066995B2
公开(公告)日：2011-11-29
申请号：US12611470
申请日：2009-11-03
申请人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda O'Bryan (Nee Tobias) , Rong Wang
发明人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda O'Bryan (Nee Tobias) , Rong Wang
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bond density, or for the treatment of various disorders in mammalian and avian species, X17251.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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公开(公告)号：US20110250205A1
公开(公告)日：2011-10-13
申请号：US13165126
申请日：2011-06-21
IPC分类号： A61K39/395 , A61P19/10 , A61P19/08 , C07K16/18
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US20110212092A1
公开(公告)日：2011-09-01
申请号：US13108073
申请日：2011-05-16
IPC分类号： A61K39/395 , C07K16/28 , A61P3/10 , A61P3/00
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to glucagon receptor polypeptide antagonists which inhibit the binding of the hormone glucagon to its receptor. More particularly, the present invention relates to high affinity glucagon receptor antibodies or Fab fragments thereof that inhibit binding of glucagon to its receptor and their use in the treatment or prevention of type 2 diabetes (NIDDM) and related disorders in mammalian species.
摘要翻译： 本发明涉及抑制激素胰高血糖素与其受体结合的胰高血糖素受体多肽拮抗剂。 更具体地，本发明涉及抑制胰高血糖素与其受体的结合的高亲和力胰高血糖素受体抗体或其Fab片段及其在哺乳动物物种中治疗或预防2型糖尿病（NIDDM）和相关病症中的用途。
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10.发明授权公开(公告)号：US07988970B2
公开(公告)日：2011-08-02
申请号：US12779438
申请日：2010-05-13
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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