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    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF
    1.
    发明申请
    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF 失效
    重组IL-9抗体及其用途

    公开(公告)号：US20120109097A1

    公开(公告)日：2012-05-03

    申请号：US13007211

    申请日：2011-01-14

    申请人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    发明人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    IPC分类号： A61B19/00 ,  C07K16/24

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

    摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。

    ABETA BINDING MOLECULES
    3.
    发明申请
    ABETA BINDING MOLECULES 有权
    ABETA结合分子

    公开(公告)号：US20090297505A1

    公开(公告)日：2009-12-03

    申请号：US12504818

    申请日：2009-07-17

    申请人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    发明人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P25/28

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease. Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.

    摘要翻译： 本发明包括分离的抗体或其片段，其是使用来自鼠抗体266的互补决定区的鼠抗体266的人源化变体。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 。 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。

    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF
    5.
    发明申请
    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF 审中-公开
    重组IL-9抗体及其用途

    公开(公告)号：US20090047277A1

    公开(公告)日：2009-02-19

    申请号：US11769326

    申请日：2007-06-27

    申请人： Jennifer Lynne REED ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    发明人： Jennifer Lynne REED ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53 ,  A61P43/00

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

    摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。

    Recombinant IL-9 antibodies
    6.
    发明授权
    Recombinant IL-9 antibodies 失效
    重组IL-9抗体

    公开(公告)号：US07354584B2

    公开(公告)日：2008-04-08

    申请号：US10823253

    申请日：2004-04-12

    申请人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    发明人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    IPC分类号： A61K39/395 ,  G01N33/53

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

    摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。

    Nucleotide sequences and proteins conferring cycloheximide resistance
    8.
    发明授权
    Nucleotide sequences and proteins conferring cycloheximide resistance 失效
    赋予放线菌酮抗性的核苷酸序列和蛋白质

    公开(公告)号：US5958687A

    公开(公告)日：1999-09-28

    申请号：US818726

    申请日：1997-03-14

    申请人： Pierre Dehoux ,  Julian Davies

    发明人： Pierre Dehoux ,  Julian Davies

    IPC分类号： C07K14/195 ,  C07K14/00 ,  C07K14/39 ,  C07K14/41 ,  C12N1/19 ,  C12N15/09 ,  C12N15/29 ,  C12R1/84 ,  C12R1/865 ,  C12Q1/68 ,  C07H21/04 ,  C12N1/14 ,  C12N15/00

    CPC分类号： C07K14/39

    摘要： The invention relates to a nucleotide sequence coding for a cycloheximide resistance protein sensitive to concatenation of amino acids A, or coding for all or part of said optionally modified concatenation A, in as much as the formed protein confers cycloheximide resistance to a recombinant eucaryotic host transformed by the nucleotide sequence coding for said protein, in conditions appropriate for its production. The invention also relates to a sequence containing the DNA coding for the concatenation A and capable of conferring a high level of resistance to cycloheximide in a given host.

    摘要翻译： 本发明涉及编码对氨基酸A的连接敏感的放线菌酮抗性蛋白的核苷酸序列，或编码所有或部分所述任选修饰的连接A，其中形成的蛋白质赋予重组真核宿主转化的放线菌酮抗性 通过编码所述蛋白的核苷酸序列，在适于其生产的条件下。 本发明还涉及包含编码级联A的DNA并且能够赋予给定宿主中高水平的放线菌酮抗性的序列。