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公开(公告)号：US08066995B2
公开(公告)日：2011-11-29
申请号：US12611470
申请日：2009-11-03
申请人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda O'Bryan (Nee Tobias) , Rong Wang
发明人： Julian Davies , Bryan Edward Jones , Andrew Ihor Korytko , Pamela Jean Mitchell , Rosamund Carol Smith , Linda O'Bryan (Nee Tobias) , Rong Wang
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bond density, or for the treatment of various disorders in mammalian and avian species, X17251.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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2.发明申请Passenger safety restraint, seat height adjustment assembly and method of restraining a passenger 审中-公开乘客安全限制，座椅高度调节组件和限制乘客的方法公开(公告)号：US20090212549A1
公开(公告)日：2009-08-27
申请号：US11920201
申请日：2006-05-08
申请人： Bryan Edward Jones
发明人： Bryan Edward Jones
IPC分类号： B60R22/20
CPC分类号： B60R22/105 , A62B35/0025 , B60N2/2866 , B60N2/7005 , B60R22/14 , B60R22/26
摘要： A restraining kit for restraining a person in a vehicle, includes a wearable harness which is wearable by a person and securing means for securing the wearable harness to a body of the vehicle when it is being worn by the person. The wearable harness includes shoulder straps, a waist strap and a crotch strap and the securing means is a second harness which is secured or securable to a seat of the vehicle. The restraining kit includes a buckle clip mechanism by which the wearable harness is securable to the second harness.
摘要翻译： 一种用于限制人员在车辆中的限制套件包括可穿戴人的可穿戴安全带和用于将人穿戴时将可穿戴安全带固定在车身上的固定装置。 可穿戴线束包括肩带，腰带和裆带，并且固定装置是固定或固定到车辆座椅上的第二线束。 限制套件包括带扣机构，通过该扣件机构，可穿戴线束可固定到第二线束。
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公开(公告)号：US20100136021A1
公开(公告)日：2010-06-03
申请号：US12693722
申请日：2010-01-26
IPC分类号： A61K39/395 , C07K16/26 , A61P9/00 , A61P29/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for mating cell proliferative disorders in a mammal.
摘要翻译： 本发明提供了非常高亲和力的抗体或其抗原结合片段，其中和成熟的人TGF-β1，TGF-β2和TGF-β1。 本发明的抗体可用于在哺乳动物中交配细胞增殖性疾病。
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公开(公告)号：US20100080811A1
公开(公告)日：2010-04-01
申请号：US12611470
申请日：2009-11-03
申请人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
发明人： JULIAN DAVIES , BRYAN EDWARD JONES , ANDREW IHOR KORYTKO , PAMELA JEAN MITCHELL , ROSAMUND CAROL SMITH , LINDA MAUREEN O'BRYAN (NEE TOBIAS) , RONG WANG
IPC分类号： A61K39/395 , A61P21/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
摘要翻译： 鉴定的抗肌生成抑制素抗体被表征为具有高亲和力，并且可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗哺乳动物和禽类物种中的各种疾病。
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公开(公告)号：US07638123B2
公开(公告)日：2009-12-29
申请号：US11678684
申请日：2007-02-26
申请人： Angelina Vucic Ciaccia , Lawrence Mark Gelbert , Brian William Grinnell , Bryan Edward Jones , David Eugene Joyce
发明人： Angelina Vucic Ciaccia , Lawrence Mark Gelbert , Brian William Grinnell , Bryan Edward Jones , David Eugene Joyce
CPC分类号： A61K38/4866 , C12Q1/56 , G01N33/86 , G01N2333/96461 , G01N2500/00 , Y10S530/868
摘要： Method of treating a disease or pathological condition with activated protein C or a compound having activated protein C activity by direct regulation of the expression of specific genes associated with the disease or pathological condition.
摘要翻译： 通过直接调节与疾病或病理状况相关的特定基因的表达，用活化蛋白C或具有活化的蛋白C活性的化合物治疗疾病或病理状况的方法。
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公开(公告)号：US20090286735A1
公开(公告)日：2009-11-19
申请号：US12421590
申请日：2009-04-09
IPC分类号： A61K38/26
CPC分类号： A61K47/183 , A61K9/0095 , A61K9/08 , A61K38/26 , A61K47/18
摘要： The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating GLP-1 receptor in a subject in need of such stimulation, by administration of the formulation of the present invention.
摘要翻译： 本发明涉及证明包含葡萄糖样肽-1化合物和特定递送剂的口服吸收的可行性的制剂以及在需要这种刺激的受试者中刺激GLP-1受体的方法，通过施用 本发明。
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公开(公告)号：US07494651B2
公开(公告)日：2009-02-24
申请号：US12096383
申请日：2006-12-20
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
摘要翻译： 本发明提供了中和成熟的人TGF-β1，TGF-β2和TGF-β3的非常高亲和力的抗体或其抗原结合片段。 本发明的抗体可用于治疗哺乳动物的细胞增殖性疾病。
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公开(公告)号：US07204981B2
公开(公告)日：2007-04-17
申请号：US10221538
申请日：2001-03-21
申请人： Angelina Vucic Ciaccia , Lawrence Mark Gelbert , Brian William Grinnell , Bryan Edward Jones , David Eugene Joyce
发明人： Angelina Vucic Ciaccia , Lawrence Mark Gelbert , Brian William Grinnell , Bryan Edward Jones , David Eugene Joyce
IPC分类号： A61K38/48 , A61K38/00 , C07K14/435
CPC分类号： A61K38/4866 , C12Q1/56 , G01N33/86 , G01N2333/96461 , G01N2500/00 , Y10S530/868
摘要： Method of treating a disease or pathological condition with activated protein C or a compound having activated protein C activity by direct regulation of the expression of specific genes associated with the disease or pathological condition.
摘要翻译： 通过直接调节与疾病或病理状况相关的特定基因的表达，用活化蛋白C或具有活化的蛋白C活性的化合物治疗疾病或病理状况的方法。
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公开(公告)号：US08492330B2
公开(公告)日：2013-07-23
申请号：US13004964
申请日：2011-01-12
IPC分类号： A61K38/00
CPC分类号： A61K47/183 , A61K9/0095 , A61K9/08 , A61K38/26 , A61K47/18
摘要： The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating GLP-1 receptor in a subject in need of such stimulation, by administration of the formulation of the present invention.
摘要翻译： 本发明涉及证明包含葡萄糖样肽-1化合物和特定递送剂的口服吸收的可行性的制剂以及在需要这种刺激的受试者中刺激GLP-1受体的方法，通过施用 本发明。
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公开(公告)号：US20110178006A1
公开(公告)日：2011-07-21
申请号：US13004964
申请日：2011-01-12
CPC分类号： A61K47/183 , A61K9/0095 , A61K9/08 , A61K38/26 , A61K47/18
摘要： The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating GLP-1 receptor in a subject in need of such stimulation, by administration of the formulation of the present invention.
摘要翻译： 本发明涉及证明包含葡萄糖样肽-1化合物和特定递送剂的口服吸收的可行性的制剂以及在需要这种刺激的受试者中刺激GLP-1受体的方法，通过施用 本发明。
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