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公开(公告)号：US07208490B2
公开(公告)日：2007-04-24
申请号：US10677551
申请日：2003-10-02
申请人： Michael Robert Barbachyn , Gordan L. Bundy , Paul Joseph Dobrowolski , Alexander Ross Hurd , Gary E. Martin , Dennis Joseph McNamara , John Raymond Palmer , Donna L. Romero , Arthur Glenn Romero , J. Craig Ruble , Debra Ann Sherry , Lisa Marie Thomasco , Peter Laurence Toogood
发明人： Michael Robert Barbachyn , Gordan L. Bundy , Paul Joseph Dobrowolski , Alexander Ross Hurd , Gary E. Martin , Dennis Joseph McNamara , John Raymond Palmer , Donna L. Romero , Arthur Glenn Romero , J. Craig Ruble , Debra Ann Sherry , Lisa Marie Thomasco , Peter Laurence Toogood
IPC分类号： C07D491/10 , C07D487/10 , A61K31/499 , A61K31/5386
CPC分类号： C07D471/20 , C07D498/10 , C07D498/20
摘要： The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens
摘要翻译： 本发明包括四氢喹啉和相关的式I化合物及其药物组合物，其对广泛的人和兽医病原体表现出有用的抗菌活性
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公开(公告)号：US06875871B2
公开(公告)日：2005-04-05
申请号：US10359767
申请日：2003-02-06
IPC分类号： G01N33/53 , A61P31/04 , C07D263/20 , C07D401/10 , C07D413/10 , G01N33/60
CPC分类号： C07D263/20 , C07B2200/05 , C07B2200/07 , C07D401/10
摘要： Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.
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公开(公告)号：US06861433B2
公开(公告)日：2005-03-01
申请号：US09738022
申请日：2000-12-15
IPC分类号： G01N33/53 , A61P31/04 , C07D263/20 , C07D401/10 , C07D413/10 , G01N33/60 , A61K31/497
CPC分类号： C07D263/20 , C07B2200/05 , C07B2200/07 , C07D401/10
摘要： The present invention provides compounds of the formula: compositions comprising such compounds, and methods for using the same.
摘要翻译： 本发明提供下式的化合物：包含这些化合物的组合物及其使用方法。
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公开(公告)号：US06858635B2
公开(公告)日：2005-02-22
申请号：US10359766
申请日：2003-02-06
IPC分类号： G01N33/53 , A61P31/04 , C07D263/20 , C07D401/10 , C07D413/10 , G01N33/60 , C07D263/08 , A61K31/421
CPC分类号： C07D263/20 , C07B2200/05 , C07B2200/07 , C07D401/10
摘要： Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.
摘要翻译： 公开了作为光亲和性探针和使用恶唑烷酮光亲和探针的方法是有用和有效的新化合物。
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公开(公告)号：US08420646B2
公开(公告)日：2013-04-16
申请号：US12972921
申请日：2010-12-20
申请人： Michael Robert Barbachyn , Paul Joseph Dobrowolski , Alexander Ross Hurd , Dennis Joseph McNamara , John Raymond Palmer , Arthur Glenn Romero , J. Craig Ruble , Debra Ann Sherry , Lisa Marie Thomasco , Peter Laurence Toogood
发明人： Michael Robert Barbachyn , Paul Joseph Dobrowolski , Alexander Ross Hurd , Dennis Joseph McNamara , John Raymond Palmer , Arthur Glenn Romero , J. Craig Ruble , Debra Ann Sherry , Lisa Marie Thomasco , Peter Laurence Toogood
IPC分类号： A61K31/5383 , A61K31/527 , C07D498/20 , C07D471/20 , C07D498/04
CPC分类号： C07D471/20 , C07D498/10 , C07D498/20
摘要： The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
摘要翻译： 本发明涉及式I的三环四氢喹啉化合物及其药学上可接受的盐，其中变量R1，R2，R3，R4，R5，R20和X如本文所述及其药物组合物，其对抗 广泛的人类和兽医病原体。
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公开(公告)号：US20100022524A1
公开(公告)日：2010-01-28
申请号：US12549407
申请日：2009-08-28
申请人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
发明人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
IPC分类号： A61K31/5386 , C07D498/20 , C07D471/20 , A61P31/00 , A61K31/499 , A61P3/04
CPC分类号： C07D471/20 , C07D498/10 , C07D498/20
摘要： The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
摘要翻译： 本发明包括四氢喹啉和相关的式I化合物及其药物组合物，其对广泛范围的人和兽医病原体表现出有用的抗菌活性。
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公开(公告)号：US06972286B2
公开(公告)日：2005-12-06
申请号：US09992660
申请日：2001-11-14
IPC分类号： A61K31/422 , A61K31/4725 , A61K31/55 , A61P31/04 , C07D413/04 , C07D417/14 , G07D223/16
CPC分类号： C07D413/04
摘要： The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.
摘要翻译： 本发明提供具有苯并通氮化的6-或7-元杂环的恶唑烷酮作为抗菌剂。
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8.发明授权
公开(公告)号：US5977373A
公开(公告)日：1999-11-02
申请号：US111995
申请日：1998-07-08
IPC分类号： A61K31/4245 , A61K31/433 , A61P31/04 , C07D413/10 , C07D417/10
CPC分类号： C07D413/10 , C07D417/10
摘要： The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I ##STR1## wherein Q is thiadiazolyl or oxadiazolyl; wherein X.sup.1 and X.sup.2 are independently hydrogen, fluorine or chlorine; andwherein R.sup.1 is, for example, --COCH.sub.3 or --COCH.sub.2 CH.sub.3.These compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive and gram-negative aerobic bacteria.
摘要翻译： 本发明提供式I的噻二唑基和恶二唑基苯基唑烷酮化合物，其中Q是噻二唑基或恶二唑基; 其中X1和X2独立地为氢，氟或氯; 并且其中R 1是例如-COCH 3或-COCH 2 CH 3。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性和革兰氏阴性的需氧细菌。
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公开(公告)号：US20110092494A1
公开(公告)日：2011-04-21
申请号：US12972921
申请日：2010-12-20
申请人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
发明人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
IPC分类号： A61K31/5383 , C07D498/20 , C07D471/20 , C07D498/04 , A61K31/527 , A61P31/00
CPC分类号： C07D471/20 , C07D498/10 , C07D498/20
摘要： The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
摘要翻译： 本发明包括四氢喹啉和相关的式I化合物及其药物组合物，其对广泛范围的人和兽医病原体表现出有用的抗菌活性。
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公开(公告)号：US07605157B2
公开(公告)日：2009-10-20
申请号：US11715213
申请日：2007-03-07
申请人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
发明人： Michael Robert Barbachyn , J. Craig Ruble , Arthur Glenn Romero , Lisa Marie Thomasco , Alexander Ross Hurd , John Raymond Palmer , Peter Laurence Toogood , Dennis Joseph McNamara , Debra Ann Sherry , Paul Joseph Dobrowolski
IPC分类号： C07D491/10 , C07D487/10 , A61K31/499 , A61K31/5386
CPC分类号： C07D471/20 , C07D498/10 , C07D498/20
摘要： The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogens
摘要翻译： 本发明包括四氢喹啉和相关的式I化合物及其药物组合物，再次显示出广泛的人类和兽医病原体的有用的抗菌活性
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