-
-
2.发明申请SPHINGO-GUANIDINES AND THEIR USE AS INHIBITORS OF SPHINGOSINE KINASE 审中-公开SPHINGO-GUANIDINES及其作为SPHINGOSINE KINASE的抑制剂公开(公告)号：US20120035268A1
公开(公告)日：2012-02-09
申请号：US13142421
申请日：2009-12-28
申请人： Zdzislaw M. Szulc , Alicja Bielawska , Lina M. Obeld , Yusuf A. Hannun , James Norris , Liu Xiang
发明人： Zdzislaw M. Szulc , Alicja Bielawska , Lina M. Obeld , Yusuf A. Hannun , James Norris , Liu Xiang
IPC分类号： A61K31/155 , C12N9/99 , A61P35/00 , A61P35/04 , A61P17/02 , A61P9/00 , A61P29/00 , A61P37/00 , A61P11/06 , A61P17/00 , C07C279/08 , A61P9/10
CPC分类号： A61K31/155 , C07C279/08
摘要： The presently disclosed subject matter provides compounds of the formula: (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting sphingosine kinase, and their use in the treatment and/or prevention of diseases and/or conditions associated with undesirable ceramidase or sphingosine kinase activity, including, but not limit cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, immunological disorders, asthma, atopic dermatitis, wound healing, and other proliferative diseases.
摘要翻译： 目前公开的主题提供下式的化合物：（1）及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。 还公开了制备如上所述的式的化合物，其用于抑制鞘氨醇激酶的方法及其在治疗和/或预防与不期望的神经酰胺酶或鞘氨醇激酶活性相关的疾病和/或病症中的用途的方法， 但不限于癌症，癌症转移，动脉粥样硬化，狭窄，炎症，免疫学障碍，哮喘，特应性皮炎，伤口愈合和其他增殖性疾病。
-
公开(公告)号：US08697379B2
公开(公告)日：2014-04-15
申请号：US13127888
申请日：2009-11-06
申请人： Alicja Bielawska , Aiping Bai , Zdzislaw M. Szulc , Yusuf A. Hannun , James S. Norris , Liu Xiang
发明人： Alicja Bielawska , Aiping Bai , Zdzislaw M. Szulc , Yusuf A. Hannun , James S. Norris , Liu Xiang
IPC分类号： A61K31/41 , A61K31/44 , C07C229/00 , C07D211/78
CPC分类号： A61K31/16 , C07C233/18
摘要： The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.
摘要翻译： 目前公开的主题提供式（Ia）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，X，Y和n如本文所定义。 还公开了制备如上所述的式的化合物，其用于抑制酸性神经酰胺酶和神经酰胺酶相关活性的方法，以及它们作为药物和前药用于治疗和/或预防与不期望的神经酰胺酶或鞘氨醇相关的疾病的用途的方法 激酶活性，包括但不限于癌症，癌症转移，动脉粥样硬化，狭窄，炎症，哮喘和特应性皮炎。
-
公开(公告)号：US20110251197A1
公开(公告)日：2011-10-13
申请号：US13127888
申请日：2009-11-06
申请人： Alicja Bielawska , Aiping Bai , Zdzislaw M. Szulc , Yusef A. Hannun , James Norris , Liu Xiang
发明人： Alicja Bielawska , Aiping Bai , Zdzislaw M. Szulc , Yusef A. Hannun , James Norris , Liu Xiang
IPC分类号： A61K31/5375 , C07D233/64 , C07D295/15 , C07C237/20 , A61K31/4164 , A61K31/165 , C07C233/47 , A61K31/216 , A61P35/00 , A61P35/04 , A61P9/00 , A61P9/10 , A61P29/00 , A61P11/06 , A61P17/00 , C12N9/99
CPC分类号： A61K31/16 , C07C233/18
摘要： The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.
摘要翻译： 目前公开的主题提供式（Ia）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，X，Y和n如本文所定义。 还公开了制备如上所述的式的化合物，其用于抑制酸性神经酰胺酶和神经酰胺酶相关活性的方法，以及它们作为药物和前药用于治疗和/或预防与不期望的神经酰胺酶或鞘氨醇相关的疾病的用途的方法 激酶活性，包括但不限于癌症，癌症转移，动脉粥样硬化，狭窄，炎症，哮喘和特应性皮炎。
-
-
-
搜索结果
4 条记录 (耗时 0.018 秒)
