公开(公告)号：US20190389904A2

公开(公告)日：2019-12-26

申请号：US15755951

申请日：2016-08-26

申请人： Nathanael S. Gray ,  David A. Scott ,  John Hatcher ,  Spandan Chennamadhavuni ,  Ari M. Melnick ,  Lorena Fontan Gabas ,  Hao Wu ,  Qi Qiao ,  Guangyan Du

发明人： Nathanael S. Gray ,  David A. Scott ,  John Hatcher ,  Spandan Chennamadhavuni ,  Ari M. Melnick ,  Lorena Fontan Gabas ,  Hao Wu ,  Qi Qiao ,  Guangyan Du

IPC分类号： C07K5/11 ,  A61K38/07

摘要： Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).