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公开(公告)号：US08088936B2
公开(公告)日：2012-01-03
申请号：US12720822
申请日：2010-03-10
申请人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： C07D317/44 , A61K31/405
CPC分类号： C07C59/68 , C07C59/90 , C07D209/08 , C07D213/38 , C07D213/61 , C07D239/26 , C07D277/24 , C07D317/54 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/24
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
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公开(公告)号：US20100240678A1
公开(公告)日：2010-09-23
申请号：US12720822
申请日：2010-03-10
申请人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： A61K31/505 , C07D317/46 , A61K31/357 , C07C59/31 , A61K31/194 , C07D333/10 , A61K31/381 , C07D319/14 , C07C317/14 , C07D239/24 , C07D209/04 , A61K31/404 , C07C229/34 , A61K31/195 , C07D213/55 , A61K31/44 , C07D277/62 , A61K31/428 , A61P29/00 , A61P11/06 , A61P11/00
CPC分类号： C07C59/68 , C07C59/90 , C07D209/08 , C07D213/38 , C07D213/61 , C07D239/26 , C07D277/24 , C07D317/54 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/24
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病
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公开(公告)号：US07625895B2
公开(公告)日：2009-12-01
申请号：US12050235
申请日：2008-03-18
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D471/04
摘要： and the pharmaceutically acceptable salts and esters thereof, X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
摘要翻译： 其药学上可接受的盐和酯，X，R 1，R 2，Y 1和Y 2如本文所述抑制MDM2蛋白与p53样肽的相互作用，因此具有抗增殖活性。
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公开(公告)号：US20090227603A1
公开(公告)日：2009-09-10
申请号：US12390725
申请日：2009-02-23
申请人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Jianping Lou , Qi Qiao , Achyutharao Siddurl , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Jianping Lou , Qi Qiao , Achyutharao Siddurl , Jefferson Wright Tilley
IPC分类号： A61K31/194 , A61K31/505 , A61K31/44 , A61K31/415 , A61K31/40 , A61K31/381 , A61K31/357 , C07D239/26 , C07D277/30 , C07D209/08 , C07D333/24 , C07C317/14 , A61P29/00
CPC分类号： C07C317/22 , C07C317/36 , C07C2601/02 , C07C2601/16 , C07D209/12 , C07D213/34 , C07D231/12 , C07D239/26 , C07D239/38 , C07D277/26 , C07D277/62 , C07D307/80 , C07D317/46 , C07D317/56 , C07D319/18 , C07D333/18
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病
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公开(公告)号：US20080255119A1
公开(公告)日：2008-10-16
申请号：US12050235
申请日：2008-03-18
申请人： Romyr Dominique , Robert Alan Goodnow , Qi Qiao , Binh Thanh Vu
发明人： Romyr Dominique , Robert Alan Goodnow , Qi Qiao , Binh Thanh Vu
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D471/04
摘要： and the pharmaceutically acceptable salts and esters thereof X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
摘要翻译： 及其药学上可接受的盐和酯X，R 1，R 2，Y 1和Y 2是 本文所述抑制MDM2蛋白与p53样肽的相互作用，因此具有抗增殖活性。
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公开(公告)号：US20190389904A2
公开(公告)日：2019-12-26
申请号：US15755951
申请日：2016-08-26
申请人： Nathanael S. Gray , David A. Scott , John Hatcher , Spandan Chennamadhavuni , Ari M. Melnick , Lorena Fontan Gabas , Hao Wu , Qi Qiao , Guangyan Du
发明人： Nathanael S. Gray , David A. Scott , John Hatcher , Spandan Chennamadhavuni , Ari M. Melnick , Lorena Fontan Gabas , Hao Wu , Qi Qiao , Guangyan Du
摘要： Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
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公开(公告)号：US09084094B2
公开(公告)日：2015-07-14
申请号：US13988098
申请日：2011-03-17
申请人： Zhihui Lin , Qi Qiao , Yi Liu
发明人： Zhihui Lin , Qi Qiao , Yi Liu
IPC分类号： H04H20/71 , H04W4/12 , H04L12/28 , H04L12/54 , H04W4/06 , H04L29/06 , H04L12/58 , H04L12/18 , H04W76/00 , H04W84/12
CPC分类号： H04W4/12 , H04L12/189 , H04L12/28 , H04L12/56 , H04L51/10 , H04L51/38 , H04L65/4076 , H04W4/06 , H04W76/40 , H04W84/12
摘要： The present disclosure discloses a method for group-transmitting multimedia messages. The method comprises the following steps: setting addresses of reception parties at a transmission terminal; after a multimedia message is edited by a user, the transmission terminal establishing a connection via Wireless Fidelity (WIFI) with reception terminals according to the addresses of the reception parties, and transmitting the multimedia message to the reception terminals via the established connection according to the addresses of the reception parties. The present disclosure further discloses a device for group-transmitting multimedia messages. The method and the device of the present disclosure realize the group-transmission of multimedia messages without limiting the size of the multimedia messages, thus profiting the development and popularization of the multimedia message service.
摘要翻译： 本公开公开了一种用于组播多媒体消息的方法。 该方法包括以下步骤：在发送终端设置接收方的地址; 在由用户编辑多媒体消息之后，发送终端根据接收方的地址与接收终端建立与无线保真（WIFI）的连接，并根据所建立的连接将接收终端发送到接收终端 接待方的地址。 本公开还公开了一种用于组传送多媒体消息的设备。 本公开的方法和设备实现多媒体消息的组传输，而不限制多媒体消息的大小，从而有利于多媒体消息服务的开发和普及。
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公开(公告)号：US20130235787A1
公开(公告)日：2013-09-12
申请号：US13988098
申请日：2011-03-17
申请人： Zhihui Lin , Qi Qiao , Yi Liu
发明人： Zhihui Lin , Qi Qiao , Yi Liu
IPC分类号： H04W4/12
CPC分类号： H04W4/12 , H04L12/189 , H04L12/28 , H04L12/56 , H04L51/10 , H04L51/38 , H04L65/4076 , H04W4/06 , H04W76/40 , H04W84/12
摘要： The present disclosure discloses a method for group-transmitting multimedia messages. The method comprises the following steps: setting addresses of reception parties at a transmission terminal; after a multimedia message is edited by a user, the transmission terminal establishing a connection via Wireless Fidelity (WIFI) with reception terminals according to the addresses of the reception parties, and transmitting the multimedia message to the reception terminals via the established connection according to the addresses of the reception parties. The present disclosure further discloses a device for group-transmitting multimedia messages. The method and the device of the present disclosure realize the group-transmission of multimedia messages without limiting the size of the multimedia messages, thus profiting the development and popularization of the multimedia message service.
摘要翻译： 本公开公开了一种用于组播多媒体消息的方法。 该方法包括以下步骤：在发送终端设置接收方的地址; 在由用户编辑多媒体消息之后，发送终端根据接收方的地址与接收终端建立与无线保真（WIFI）的连接，并根据所建立的连接将接收终端发送到接收终端 接待方的地址。 本公开还公开了一种用于组传送多媒体消息的设备。 本公开的方法和设备实现多媒体消息的组传输，而不限制多媒体消息的大小，从而有利于多媒体消息服务的开发和普及。
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公开(公告)号：US20130115940A1
公开(公告)日：2013-05-09
申请号：US13259212
申请日：2010-10-12
IPC分类号： H04W48/16
摘要： The present invention discloses a method and an apparatus of downloading files based on wireless fidelity WIFI. The method comprises: setting a download task, searching an access point for accessing the network; and judging whether the found access point is a WIFI access point; if it is a WIFI access point, then downloading a file indicated by the download task. With the present invention, when a user departs the coverage area of current WIFI access point or the current WIFI access point fails, the system can automatically store the unfinished download task and continuously search a WIFI access point and continue to download the file indicated by the stored download task according to a preset condition after accessing a WIFI access point, thus overcoming the problem that there is limit in using WIFI to download files in the related art, simplifying user operation, and improving user experience.
摘要翻译： 本发明公开了一种基于无线保真WIFI下载文件的方法和装置。 该方法包括：设置下载任务，搜索接入点以访问网络; 判断发现的接入点是否为WIFI接入点; 如果是WIFI接入点，则下载由下载任务指定的文件。 利用本发明，当用户离开当前WIFI接入点的覆盖区域或者当前WIFI接入点出现故障时，系统可以自动存储未完成的下载任务，并连续搜索WIFI接入点，并继续下载由 在访问WIFI接入点之后，根据预设条件存储下载任务，从而克服了使用WIFI下载相关技术中的文件有限制的问题，简化了用户操作，并提高了用户体验。
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公开(公告)号：US20120184548A1
公开(公告)日：2012-07-19
申请号：US13347726
申请日：2012-01-11
申请人： Romyr Dominique , Kin-Chun Luk , Qi Qiao , Pamela Loreen Rossman
发明人： Romyr Dominique , Kin-Chun Luk , Qi Qiao , Pamela Loreen Rossman
IPC分类号： A61K31/4704 , C07D413/12 , A61P25/28 , A61P35/00 , A61P43/00 , C07D215/54 , A61K31/5377
CPC分类号： C07D215/54 , C07D401/12 , C07D413/12
摘要： Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer.
摘要翻译： 本发明描述了式及其药学上可接受的盐的化合物，以及含有所述化合物及其药学上可接受的盐的药物组合物，以及所述化合物和药物组合物用于治疗，控制或改善包括癌症在内的增殖性疾病的用途。
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