公开(公告)号：US20140186937A1

公开(公告)日：2014-07-03

申请号：US13906719

申请日：2013-05-31

申请人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

发明人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

IPC分类号： C12M3/00

CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

摘要翻译： 本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。 一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。 流体容纳系统由壳体支撑并且与生物反应器流体连通。 一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。 本发明的系统，方法和产品可用于各种临床和实验室设置。