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    AUTOMATED TISSUE ENGINEERING SYSTEM
    1.
    发明申请
    AUTOMATED TISSUE ENGINEERING SYSTEM 有权
    自动组织工程系统

    公开(公告)号：US20140186937A1

    公开(公告)日：2014-07-03

    申请号：US13906719

    申请日：2013-05-31

    申请人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

    发明人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

    IPC分类号： C12M3/00

    CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

    摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

    摘要翻译： 本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。 一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。 流体容纳系统由壳体支撑并且与生物反应器流体连通。 一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。 本发明的系统，方法和产品可用于各种临床和实验室设置。

    Advanced Tissue Engineering System
    2.
    发明申请
    Advanced Tissue Engineering System 有权
    高级组织工程系统

    公开(公告)号：US20080113426A1

    公开(公告)日：2008-05-15

    申请号：US11597550

    申请日：2005-05-26

    申请人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    发明人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    IPC分类号： C12M3/00

    CPC分类号： C12M21/08 ,  C12M23/24 ,  C12M23/34 ,  C12M23/44 ,  C12M25/14 ,  C12M27/16 ,  C12M41/12 ,  C12M45/09 ,  C12M47/04

    摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

    摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

    Advanced tissue engineering system
    3.
    发明授权
    Advanced tissue engineering system 有权
    高级组织工程系统

    公开(公告)号：US09499780B2

    公开(公告)日：2016-11-22

    申请号：US11597550

    申请日：2005-05-26

    申请人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    发明人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/12

    CPC分类号： C12M21/08 ,  C12M23/24 ,  C12M23/34 ,  C12M23/44 ,  C12M25/14 ,  C12M27/16 ,  C12M41/12 ,  C12M45/09 ,  C12M47/04

    摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

    摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳在一起。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

    Automated tissue engineering system
    4.
    发明授权
    Automated tissue engineering system 有权
    自动组织工程系统

    公开(公告)号：US08492140B2

    公开(公告)日：2013-07-23

    申请号：US10510777

    申请日：2003-04-08

    申请人： Timothy J. N. Smith ,  Martin R. Pecaric ,  Sydney J. Pugh ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misner

    发明人： Timothy J. N. Smith ,  Martin R. Pecaric ,  Sydney J. Pugh ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misner

    IPC分类号： C12M1/00 ,  C12M1/34 ,  C12N3/00

    CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

    摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

    摘要翻译： 本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。 一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。 流体容纳系统由壳体支撑并且与生物反应器流体连通。 一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。 本发明的系统，方法和产品可用于各种临床和实验室设置。

    Identification of tissue/cell specific marker genes and use thereof
    5.
    发明申请
    Identification of tissue/cell specific marker genes and use thereof 审中-公开
    鉴定组织/细胞特异性标记基因及其用途

    公开(公告)号：US20060008803A1

    公开(公告)日：2006-01-12

    申请号：US10517756

    申请日：2003-06-12

    申请人： Andreas Brunner ,  Rupert Hagg ,  Roberto Tommasini

    发明人： Andreas Brunner ,  Rupert Hagg ,  Roberto Tommasini

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/158

    摘要： A cartilage array comprises a plurality of different polynucleotide probe spots stably associated with a solid surface of a carrier, whereby each of said spots is made of a unique polynucleotide that corresponds to one specific cartilage marker gene. Said specific cartilage marker genes preferably are at least in part selected from a group of 467 genes that could be shown to be cartilage related.

    摘要翻译： 软骨阵列包括与载体的固体表面稳定相关的多个不同的多核苷酸探针点，其中每个所述斑点由对应于一个特定软骨标记基因的唯一多核苷酸制成。 所述特定的软骨标记基因优选至少部分选自可以显示为软骨相关的467个基因的一组。