公开(公告)号：US6010715A

公开(公告)日：2000-01-04

申请号：US954861

申请日：1997-10-21

申请人： John J. Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

发明人： John J. Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

IPC分类号： A61K9/70 ,  A61F13/02

CPC分类号： A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, the active ingredient is heat stable at the melt temperature of the matrix polymer and is selected from active agents, active agent enhancers and mixtures thereof, and the laminate is provided with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed.

摘要翻译： 公开了用于将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层和由活性成分与热塑性基质聚合物的熔体共混物形成的整体载体层的叠层体，而没有首先溶解 或将聚合物或活性成分悬浮在其溶剂中，使得载体层基本上不含残留溶剂，其中热塑性基质聚合物的熔体温度在约170℃至约200℃之间，并且选自聚醚 嵌段酰胺，乙烯甲基丙烯酸共聚物，乙烯丙烯酸共聚物，聚醚预聚物与聚对苯二甲酸丁二醇酯的共聚物，聚醚预聚物与聚异丁烯对苯二甲酸酯和聚醚聚氨酯的共聚物，活性成分在基体聚合物的熔融温度下是热稳定的， 活性剂，活性剂增强剂及其混合物，以及Lami 本发明提供了用于将层压材料固定到主体的皮肤或粘膜上的装置，使得活性成分从载体层连续释放。 还公开了组装装置的方法。

公开(公告)号：US5679373A

公开(公告)日：1997-10-21

申请号：US477042

申请日：1995-06-07

申请人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

发明人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61F13/02

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.

摘要翻译： 公开了将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层的叠层，选自活性成分的活性成分的整体载体层，活性剂增强剂及其混合物，熔体 与能够可控地释放活性成分的热塑性基质聚合物共混，其中活性成分在基质聚合物的熔融温度下是热稳定的，以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性成分 成分从载体层连续释放。 还公开了用于组装装置的方法，其中能够可控地释放活性成分的热塑性基质聚合物与在基质聚合物的熔融温度下热稳定的活性成分熔融共混，使得熔融共混物 形成活性成分和热塑性基质聚合物，将该熔融共混物形成为整体载体层，然后将载体层与背衬层组合，并将该层压材料固定在主体的皮肤或粘膜上，使得 活性成分从载体层释放出来。

公开(公告)号：US5503844A

公开(公告)日：1996-04-02

申请号：US63515

申请日：1993-05-18

申请人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

发明人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

IPC分类号： A61K9/70 ,  A61F13/00 ,  A61F13/02

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

摘要翻译： 公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。 还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。 还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

公开(公告)号：US5676969A

公开(公告)日：1997-10-14

申请号：US477312

申请日：1995-06-07

申请人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

发明人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61F13/02

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.

摘要翻译： 公开了将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层的叠层，选自活性成分的活性成分的整体载体层，活性剂增强剂及其混合物，熔体 与能够可控地释放活性成分的热塑性基质聚合物共混，其中活性成分在基质聚合物的熔融温度下是热稳定的，以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性成分 成分从载体层连续释放。 还公开了用于组装装置的方法，其中能够可控地释放活性成分的热塑性基质聚合物与在基质聚合物的熔融温度下热稳定的活性成分熔融共混，使得熔融共混物 形成活性成分和热塑性基质聚合物，将该熔融共混物形成为整体载体层，然后将载体层与背衬层组合，并将该层压材料固定在主体的皮肤或粘膜上，使得 活性成分从载体层释放出来。

公开(公告)号：US5662926A

公开(公告)日：1997-09-02

申请号：US426492

申请日：1995-04-20

申请人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

发明人： John Wick ,  Ludwig J. Weimann ,  Wayne C. Pollock

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61F13/02

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.

公开(公告)号：US5629014A

公开(公告)日：1997-05-13

申请号：US476418

申请日：1995-06-07

申请人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

发明人： Alfred Kwiatek ,  Ludwig J. Weimann ,  Wayne C. Pollock ,  Sharad K. Govil

IPC分类号： A61K9/70 ,  A61F13/00

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

摘要翻译： 公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。 还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。 还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

公开(公告)号：US20100303883A1

公开(公告)日：2010-12-02

申请号：US12738113

申请日：2008-10-17

申请人： Wayne C. Pollock ,  Stuart A. Grossman ,  Albert H. Owens

发明人： Wayne C. Pollock ,  Stuart A. Grossman ,  Albert H. Owens

IPC分类号： A61F2/00 ,  A61K31/485 ,  A61P29/00 ,  B05D3/00

CPC分类号： A61K31/485 ,  A61K9/0024 ,  A61K47/34 ,  B29C45/0001 ,  B29C48/06 ,  B29C48/08 ,  B29C48/18 ,  B29K2105/0035

摘要： Implants are disclosed for delivery of therapeutic agents such as opioids and the manufacture and uses of such implants.

摘要翻译： 公开了用于递送治疗剂如阿片样物质以及这种植入物的制造和用途的植入物。

公开(公告)号：US20130236524A1

公开(公告)日：2013-09-12

申请号：US13606795

申请日：2012-09-07

申请人： Richard J. HOLL ,  Katherine HARTMAN ,  Stuart A. Grossman ,  Wayne C. Pollock

发明人： Richard J. HOLL ,  Katherine HARTMAN ,  Stuart A. Grossman ,  Wayne C. Pollock

IPC分类号： A61K9/00 ,  A61K31/485

CPC分类号： A61K9/0002 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34

摘要： Implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants are provided. In particular, subcutaneous drug delivery systems having a biocompatible thermoplastic elastomeric polymer matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible drug impermeable cross-linked silicone polymer coating said matrix and methods of making the same are provided.

摘要翻译： 提供用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。 特别地，提供了具有生物相容性热塑性弹性体聚合物基质，均匀地嵌入所述基质中的治疗剂和涂覆所述基质的生物相容性药物不可渗透交联的硅氧烷聚合物的皮下药物递送系统及其制备方法。

公开(公告)号：US20120034306A1

公开(公告)日：2012-02-09

申请号：US13264813

申请日：2010-04-19

申请人： Wayne C. Pollock ,  Stuart A. Grossman ,  Albert H. Owens, JR.

发明人： Wayne C. Pollock ,  Stuart A. Grossman ,  Albert H. Owens, JR.

IPC分类号： A61K9/00 ,  A61P25/04 ,  A61K9/28 ,  A61K31/485

CPC分类号： A61K9/0024 ,  A61K31/485 ,  A61K47/34 ,  B29C45/00 ,  B29L2031/753

摘要： The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

摘要翻译： 本发明涉及用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。