公开(公告)号：US07647092B2

公开(公告)日：2010-01-12

申请号：US10178062

申请日：2002-06-21

申请人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

发明人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

IPC分类号： A61B6/06

CPC分类号： A61B5/02007 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/4312 ,  A61B5/4519 ,  A61B5/7232 ,  G01N21/474 ,  G01N21/65 ,  G01N2021/4745 ,  G01N2021/4759 ,  G01N2021/656

摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.

摘要翻译： 本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。 根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。 这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。 输送光纤包括在近端耦合到光源的探针中。 用于输送纤维的过滤器包括在远端。 该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。 第二过滤器设置在收集纤维的远端。 光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。