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公开(公告)号：US20170137529A1
公开(公告)日：2017-05-18
申请号：US14974042
申请日：2015-12-18
申请人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
发明人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that binds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
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公开(公告)号：US08623357B2
公开(公告)日：2014-01-07
申请号：US12316621
申请日：2008-12-15
申请人： Hermann Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
发明人： Hermann Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
IPC分类号： A61K39/395
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标相对的治疗性蛋白质，所述蛋白质用抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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公开(公告)号：US20140212418A1
公开(公告)日：2014-07-31
申请号：US13955785
申请日：2013-07-31
申请人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
发明人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
IPC分类号： C07K16/28
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标相对的治疗性蛋白质，所述蛋白质用抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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公开(公告)号：US07465790B2
公开(公告)日：2008-12-16
申请号：US09979948
申请日：2001-10-09
申请人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
发明人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
IPC分类号： C60K14/00 , A61K39/395
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that binds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标结合的治疗性蛋白质，所述蛋白质被抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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公开(公告)号：US20100015166A1
公开(公告)日：2010-01-21
申请号：US12316621
申请日：2008-12-15
申请人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
发明人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
IPC分类号： A61K39/395 , C07K2/00 , C07K16/00 , C07K19/00 , A61K38/02
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标相对的治疗性蛋白质，所述蛋白质用抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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