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公开(公告)号：US20180256679A1
公开(公告)日：2018-09-13
申请号：US15975591
申请日：2018-05-09
IPC分类号： A61K38/17 , C07K14/705 , A61K38/10 , C12N5/0783
CPC分类号： A61K38/177 , A61K38/10 , A61K47/68 , A61K48/00 , C07K14/70592 , C07K16/18 , C07K2319/30 , C12N5/0637 , C12Q1/6883 , G01N33/505 , G01N33/6872
摘要： The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.
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公开(公告)号：US20170232061A1
公开(公告)日：2017-08-17
申请号：US15384137
申请日：2016-12-19
发明人： Esther Bandala Sanchez , James Dromey , Leonard Charles Harrison , Yuxia Zhang , Maryam Rashidi
IPC分类号： A61K38/17
CPC分类号： A61K38/177 , A61K38/10 , A61K47/68 , A61K48/00 , C07K14/70592 , C07K16/18 , C07K2319/30 , C12N5/0637 , C12Q1/6883 , G01N33/505 , G01N33/6872
摘要： The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.
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公开(公告)号：US20240026410A1
公开(公告)日：2024-01-25
申请号：US18315332
申请日：2023-05-10
申请人： Genzyme Corporation
发明人： Victor R. Cairns , Christine DeMaria , Jason Vitko
IPC分类号： C12P21/00 , C12N15/85 , C07K14/705 , C07K14/435 , C12N5/00 , C12N5/10 , G01N15/14
CPC分类号： C12P21/00 , C12N15/85 , C07K14/70596 , C07K14/43504 , C12N5/0087 , C12N5/10 , G01N15/14 , C07K14/435 , C07K14/70592 , G01N2015/149
摘要： Provided herein are methods for selecting a population of cells expressing a target polypeptide. In some aspects, the disclosure provides methods for sorting and selecting populations of transfected host cells based on their early expression of a selectable polypeptide. In certain embodiments, the sorting is performed using fluorescence-activated cell sorting or magnetic-activated cell sorting based on the selectable polypeptide. Such selection methods can be further utilized to generate clonal populations of producer cells, e.g. for large-scale manufacturing of a target polypeptide of interest.
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公开(公告)号：US11685943B2
公开(公告)日：2023-06-27
申请号：US16683837
申请日：2019-11-14
申请人： Genzyme Corporation
发明人： Victor R. Cairns , Christine DeMaria , Jason Vitko
IPC分类号： C12N15/00 , C12P21/00 , C12N15/85 , C07K14/705 , C07K14/435 , C12N5/00 , C12N5/10 , G01N15/14
CPC分类号： C12P21/00 , C07K14/435 , C07K14/43504 , C07K14/70592 , C07K14/70596 , C12N5/0087 , C12N5/10 , C12N15/85 , G01N15/14 , G01N2015/149
摘要： Provided herein are methods for selecting a population of cells expressing a target polypeptide. In some aspects, the disclosure provides methods for sorting and selecting populations of transfected host cells based on their early expression of a selectable polypeptide. In certain embodiments, the sorting is performed using fluorescence-activated cell sorting or magnetic-activated cell sorting based on the selectable polypeptide. Such selection methods can be further utilized to generate clonal populations of producer cells, e.g. for large-scale manufacturing of a target polypeptide of interest.
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公开(公告)号：US20140212418A1
公开(公告)日：2014-07-31
申请号：US13955785
申请日：2013-07-31
申请人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
发明人： Herman Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes Da Silva Graca
IPC分类号： C07K16/28
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标相对的治疗性蛋白质，所述蛋白质用抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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公开(公告)号：US09585969B2
公开(公告)日：2017-03-07
申请号：US14351501
申请日：2012-11-15
IPC分类号： A61K38/10 , A61K47/48 , C07K14/705 , G01N33/68 , C12N5/0783 , C07K16/18 , C12Q1/68 , G01N33/50 , A61K48/00
CPC分类号： A61K38/177 , A61K38/10 , A61K47/68 , A61K48/00 , C07K14/70592 , C07K16/18 , C07K2319/30 , C12N5/0637 , C12Q1/6883 , G01N33/505 , G01N33/6872
摘要： The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.
摘要翻译： 本公开涉及可溶性CD52糖蛋白及其在治疗由效应T细胞调节的疾病中的用途，例如自身免疫性疾病如1型糖尿病。 本公开还涉及包含可溶性糖蛋白的融合蛋白与表达高水平的CD52的细胞，以及基于检测受试者中CD52表达水平的诊断方法。
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公开(公告)号：US20150259412A1
公开(公告)日：2015-09-17
申请号：US14440703
申请日：2013-03-25
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/70592 , C07K16/2803 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K2317/76 , C07K2319/30 , C12N5/0637 , G01N33/502 , G01N33/564 , G01N33/6872 , G01N33/6893 , G01N2333/70592 , G01N2800/26 , G01N2800/285 , G01N2800/50 , G01N2800/52
摘要： The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.
摘要翻译： 本公开涉及可溶性CD52糖蛋白在治疗由效应T细胞调节的疾病中的用途，例如败血症或多发性硬化症。 本公开还涉及基于检测受试者中CD52表达水平的诊断方法。
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公开(公告)号：US08623357B2
公开(公告)日：2014-01-07
申请号：US12316621
申请日：2008-12-15
申请人： Hermann Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
发明人： Hermann Waldmann , Mark Raymond Frewin , Lisa Kim Gilliland , Luis Richardo Simoes da Silva Graca
IPC分类号： A61K39/395
CPC分类号： C07K16/2893 , A61K47/6849 , A61K2039/505 , C07K14/70592 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2318/10 , C07K2319/00
摘要： A pharmaceutical comprising a therapeutic protein that hinds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.
摘要翻译： 一种药物，其包含与治疗靶标相对的治疗性蛋白质，所述蛋白质用抑制蛋白质与治疗靶标结合的化合物修饰，所述修饰蛋白质有效降低针对所述蛋白质的免疫应答并产生治疗效果 通过结合治疗靶标。 治疗性蛋白质可以是包含结合治疗靶标的抗体结合位点的抗体。
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公开(公告)号：US5786176A
公开(公告)日：1998-07-28
申请号：US374533
申请日：1995-02-03
申请人： Geoffrey Hale , Herman Waldmann , Masahide Tone , John Tite , Christine Hale
发明人： Geoffrey Hale , Herman Waldmann , Masahide Tone , John Tite , Christine Hale
IPC分类号： G01N33/574 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , G01N33/53
CPC分类号： C07K14/70592
摘要： The invention relates to recombinant cell lines, in particular mamalian cell lines, capable of expressing recombinant CDw52 antigen or an antigenic fragment thereof. The cell lines can be used for the production of recombinant CDw52 antigen and in assaying for anti-CDw52 antibody in a sample.
摘要翻译： PCT No.PCT / GB93 / 01482 Sec。 371日期：1995年2月3日 102（e）日期1995年2月3日PCT提交1993年7月14日PCT公布。 公开号WO94 / 02604 日期1994年2月3日本发明涉及能够表达重组CDw52抗原或其抗原性片段的重组细胞系，特别是mamalian细胞系。 细胞系可用于重组CDw52抗原的生产和样品中抗CDw52抗体的测定。
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公开(公告)号：US20180119192A1
公开(公告)日：2018-05-03
申请号：US15727272
申请日：2017-10-06
申请人： Genzyme Corporation
发明人： Victor R. Cairns , Christine DeMaria , Jason Vitko
IPC分类号： C12P21/00 , C12N15/85 , C07K14/705 , C07K14/435
CPC分类号： C12P21/00 , C07K14/435 , C07K14/70592 , C12N15/85
摘要： Provided herein are methods for selecting a population of cells expressing a target polypeptide. In some aspects, the disclosure provides methods for sorting and selecting populations of transfected host cells based on their early expression of a selectable polypeptide. In certain embodiments, the sorting is performed using fluorescence-activated cell sorting or magnetic-activated cell sorting based on the selectable polypeptide. Such selection methods can be further utilized to generate clonal populations of producer cells, e.g. for large-scale manufacturing of a target polypeptide of interest.
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