公开(公告)号：US07981095B2

公开(公告)日：2011-07-19

申请号：US11541291

申请日：2006-09-29

申请人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

发明人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

IPC分类号： A61M35/00 ,  A61F7/00 ,  A61B18/04

CPC分类号： A61F9/0008 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/0026 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H35/02 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1607 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20110022010A1

公开(公告)日：2011-01-27

申请号：US12887165

申请日：2010-09-21

申请人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

发明人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

IPC分类号： A61M35/00

CPC分类号： A61F9/0008 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/0026 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H35/02 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1607 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US07833205B2

公开(公告)日：2010-11-16

申请号：US11931646

申请日：2007-10-31

申请人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

发明人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

IPC分类号： A61M35/00

CPC分类号： A61F9/00 ,  A61B17/3203 ,  A61B18/04 ,  A61B2018/046 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20070142912A1

公开(公告)日：2007-06-21

申请号：US11707222

申请日：2007-02-15

申请人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

发明人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

IPC分类号： A61F2/16 ,  A61F9/013

CPC分类号： A61F2/1602 ,  A61F2/1608 ,  A61F2002/1681 ,  A61F2220/0008

摘要： A refractive intraocular lens adapted to be inserted within the human eye and to work in combination with the human crystalline lens and comprises an optic, a haptic, a riser and a connector. The optic has an anterior side and a posterior side and is adapted to produce a preselected refractive optical effect for the correction of presbyopia. A haptic is connected to the optic for fixating the refractive intraocular lens within the eye. A riser is operatively associated with the haptic for maintaining the optic in spaced relation from the iris. A connector for attaching the intraocular lens to the iris is provided that penetrates less than the entire thickness of the iris.

摘要翻译： 一种折射型眼内透镜，其适于插入人眼内并与人体晶状体组合工作，并且包括光学元件，触觉件，立管和连接器。 光学元件具有前侧和后侧，并且适于产生用于矫正老花眼的预选折射光学效应。 触觉件连接到光学元件以将折射眼内透镜固定在眼睛内。 提升器与触觉件可操作地相关联，用于将光学元件保持与虹膜间隔开的关系。 提供用于将眼内透镜附接到虹膜的连接器，其穿透小于整个虹膜的厚度。

公开(公告)号：US20070142911A1

公开(公告)日：2007-06-21

申请号：US11706905

申请日：2007-02-15

申请人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

发明人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

IPC分类号： A61F2/16

CPC分类号： A61F2/1602 ,  A61F2002/1681 ,  A61F2220/0008

摘要： A refractive intraocular lens adapted to be inserted within the human eye and to work in combination with the human crystalline lens and comprises an optic, a haptic, a riser and a connector. The optic has an anterior side and a posterior side and is adapted to produce a preselected refractive optical effect for the correction of presbyopia. A haptic is connected to the optic for fixating the refractive intraocular lens within the eye. A riser is operatively associated with the haptic for maintaining the optic in spaced relation from the iris. A connector for attaching the intraocular lens to the iris is provided that penetrates less than the entire thickness of the iris.

公开(公告)号：US20050015143A1

公开(公告)日：2005-01-20

申请号：US10919171

申请日：2004-08-16

申请人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

发明人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

IPC分类号： A61F9/007 ,  A61F2/16

CPC分类号： A61F2/1608 ,  A61F2/15 ,  A61F2220/0008 ,  A61F2220/0016

摘要： A refractive intraocular lens (104) and method of locating the lens within the eye and attaching the lens to the iris. The refractive intraocular lens (104) may be attached via a staple (230), a fastener (312), anchor (412) or by the tip of the haptic (118).

摘要翻译： 折射眼内透镜（104）以及将透镜定位在眼睛内并将透镜附接到虹膜的方法。 屈光眼内透镜（104）可以经由钉（230），紧固件（312），锚固件（412）或由触觉件（118）的尖端附接。

公开(公告)号：US08628504B2

公开(公告)日：2014-01-14

申请号：US12887165

申请日：2010-09-21

申请人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

发明人： Stephen M. Grenon ,  Lyle Paul ,  Steven Roe ,  Donald R. Korb

IPC分类号： A61M35/00

CPC分类号： A61F9/0008 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/0026 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H35/02 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1607 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20070049913A1

公开(公告)日：2007-03-01

申请号：US11541291

申请日：2006-09-29

申请人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

发明人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

IPC分类号： A61B18/04 ,  A61F7/00

CPC分类号： A61F9/0008 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/0026 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H35/02 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1607 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20060142856A1

公开(公告)日：2006-06-29

申请号：US11335080

申请日：2006-01-19

申请人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

发明人： Timothy Willis ,  Lyle Paul ,  Joseph Collin

IPC分类号： A61F2/16

CPC分类号： A61F2/1602 ,  A61F2/1608 ,  A61F2002/1681 ,  A61F2220/0008

摘要： A refractive intraocular lens (104) and method of locating the lens within the eye and attaching the lens to the iris. The refractive intraocular lens (104) may be attached via a staple (230), a fastener (312), anchor (412) or by the tip of the haptic (118). The intraocular lens (104) works in combination with the human crystalline lens to treat conditions selected from the group consisting of myopia, hyperopia and astigmatism.

摘要翻译： 折射眼内透镜（104）以及将透镜定位在眼睛内并将透镜附接到虹膜的方法。 屈光眼内透镜（104）可以经由钉（230），紧固件（312），锚固件（412）或由触觉件（118）的尖端附接。 眼内透镜（104）与人体晶状体组合起作用以治疗选自近视，远视和散光的病症。

公开(公告)号：US20080051741A1

公开(公告)日：2008-02-28

申请号：US11931646

申请日：2007-10-31

申请人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

发明人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

IPC分类号： A61F9/00

CPC分类号： A61F9/00 ,  A61B17/3203 ,  A61B18/04 ,  A61B2018/046 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。