公开(公告)号：US06861506B1

公开(公告)日：2005-03-01

申请号：US09534825

申请日：2000-03-23

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/15 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/68 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/12022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。

公开(公告)号：US20130052195A1

公开(公告)日：2013-02-28

申请号：US13518184

申请日：2010-12-23

申请人： Lynda E. Misher ,  Alan Keith Lofquist

发明人： Lynda E. Misher ,  Alan Keith Lofquist

IPC分类号： A61K39/395 ,  A61P1/00 ,  A61P19/04 ,  A61P17/06 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07K16/248 ,  A61K2039/507 ,  C07K16/241

摘要： The present disclosure relates to compositions and methods for treating autoimmune diseases including rheumatoid arthritis. In particular, the present disclosure relates to compositions comprising IL-6 antagonists (e.g., anti-IL6 or anti-IL6R or anti-hyperIL6) and TNF-α antagonists (e.g., (anti-TNF or etanercept) and methods of using same in the treatment of rheumatoid arthritis.

摘要翻译： 本公开涉及用于治疗包括类风湿性关节炎的自身免疫性疾病的组合物和方法。 特别地，本公开内容涉及包含IL-6拮抗剂（例如，抗IL6或抗IL6R或抗-ILIL6）和TNF-α拮抗剂（例如，（抗TNF或依那西普）的组合物及其使用方法 治疗类风湿性关节炎。

公开(公告)号：US07241876B2

公开(公告)日：2007-07-10

申请号：US09924400

申请日：2001-08-07

申请人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker ,  Craig H. Day ,  Samuel X. Li ,  Ta Deng

发明人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker ,  Craig H. Day ,  Samuel X. Li ,  Ta Deng

IPC分类号： C07H21/02

CPC分类号： C12Q1/6886 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/14022 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US06828431B1

公开(公告)日：2004-12-07

申请号：US09699295

申请日：2000-10-26

申请人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker

发明人： Tony N. Frudakis ,  Steven G. Reed ,  John M. Smith ,  Lynda E. Misher ,  Davin C. Dillon ,  Marc W. Retter ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Susan L. Harlocker

IPC分类号： C12Q170

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/11022 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S436/813

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.