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公开(公告)号：US07754207B2
公开(公告)日：2010-07-13
申请号：US11925330
申请日：2007-10-26
Applicant: William Glass , Lynne Murray
Inventor： William Glass , Lynne Murray
IPC: A61K39/395 , C07K14/435
CPC classification number: C07K16/244
Abstract: Methods for treating pathological pulmonary conditions and bleomycin associated pulmonary fibrosis administer IL-16 antagonists, for example, anti-IL-16 antibodies, to subjects.
Abstract translation: 用于治疗病理性肺病和博来霉素相关肺纤维化的方法将受试者的IL-16拮抗剂，例如抗IL-16抗体。
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公开(公告)号：US20110071277A1
公开(公告)日：2011-03-24
申请号：US12722950
申请日：2010-03-12
Applicant: Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
Inventor： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC: C07K16/00
CPC classification number: C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
Abstract translation: 公开了抵抗素拮抗剂，包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。
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公开(公告)号：US09082459B2
公开(公告)日：2015-07-14
申请号：US11865358
申请日：2007-10-01
Applicant: Shawn Allen Ruden , Sabrina Lynne Murray
Inventor： Shawn Allen Ruden , Sabrina Lynne Murray
CPC classification number: G11B33/0472
Abstract: A disc caddy and associated method for handling is characterized by a disc cassette having opposing longitudinal side walls joined to opposing lateral end walls forming a substantially rectangular structure defining open first and second ends. A first removable cover is provided for closing the first end, and a second removable cover is provided for closing the second end. The second removable cover defines barb members that latchingly engage respective strikes defined by the first removable cover that extend substantially parallel to the end walls. The disc cassette has protuberant features defining reference hold-down surfaces, and the first removable cover defines clearance apertures through which the hold-down surfaces extend.
Abstract translation: 圆盘盒和相关的处理方法的特征在于盘盒具有连接到相对的侧端壁的相对的纵向侧壁，其形成限定开口的第一和第二端的基本上矩形的结构。 提供第一可移除盖以封闭第一端，并且提供第二可移除盖以闭合第二端。 第二可移除盖限定倒钩构件，其闩锁地接合由基本上平行于端壁延伸的第一可移除盖限定的相应撞击。 盘盒具有限定参考压紧表面的突出特征，并且第一可移除盖限定了压紧表面延伸通过的间隙孔。
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Patent Agency Ranking
公开(公告)号：US20100074886A1
公开(公告)日：2010-03-25
申请号：US12442404
申请日：2007-10-05
Applicant: Anuk Das , Lynne Murray , Fahrat Syed
Inventor： Anuk Das , Lynne Murray , Fahrat Syed
IPC: A61K39/395 , A61K38/16 , A61K31/404 , A61P7/00
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: Anti-MCP-1/CCR2 antagonist therapy is provided for the control or reversal of fibrosis related diseases, including, e.g., but not limited to MCP-1/CCR2 antagonist therapy for the modulation of profibrotic markers associated with fibrotic processes including collagen matrix deposition and alveolar collapse.
Abstract translation: 提供了抗MCP-1 / CCR2拮抗剂治疗用于控制或逆转纤维化相关疾病，包括例如但不限于MCP-1 / CCR2拮抗剂治疗用于调节纤维化过程（包括胶原基质沉积）的纤维化性标记 和肺泡塌陷。
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公开(公告)号：US20090117122A1
公开(公告)日：2009-05-07
申请号：US12233683
申请日：2008-09-19
Applicant: Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
Inventor： Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
IPC: A61K39/395 , C07K16/18 , C07K7/08 , C07H21/00
CPC classification number: C07H21/04 , A61K2039/505 , C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Antigens useful for raising antibodies against human resistin are also disclosed.
Abstract translation: 公开了抗性拮抗剂，包括与限定的表位反应的抗体。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了可用于提高抗人抵抗素抗体的抗原。
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公开(公告)号：US20090162375A1
公开(公告)日：2009-06-25
申请号：US11924108
申请日：2007-10-25
Applicant: Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
Inventor： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC: A61K39/395 , C07K16/26 , C07K7/08 , C07H21/00 , C12Q1/02
CPC classification number: C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
Abstract translation: 公开了抗性拮抗剂，包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。
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公开(公告)号：US20090084696A1
公开(公告)日：2009-04-02
申请号：US11865358
申请日：2007-10-01
Applicant: Shawn Allen Ruden , Sabrina Lynne Murray
Inventor： Shawn Allen Ruden , Sabrina Lynne Murray
CPC classification number: G11B33/0472
Abstract: A disc caddy and associated method for handling is characterized by a disc cassette having opposing longitudinal side walls joined to opposing lateral end walls forming a substantially rectangular structure defining open first and second ends. A first removable cover is provided for closing the first end, and a second removable cover is provided for closing the second end. The second removable cover defines barb members that latchingly engage respective strikes defined by the first removable cover that extend substantially parallel to the end walls. The disc cassette has protuberant features defining reference hold-down surfaces, and the first removable cover defines clearance apertures through which the hold-down surfaces extend.
Abstract translation: 圆盘盒和相关的处理方法的特征在于盘盒具有连接到相对的侧端壁的相对的纵向侧壁，其形成限定开口的第一和第二端的基本上矩形的结构。 提供第一可移除盖以封闭第一端，并且提供第二可移除盖以闭合第二端。 第二可移除盖限定倒钩构件，其闩锁地接合由基本上平行于端壁延伸的第一可移除盖限定的相应撞击。 盘盒具有限定参考压紧表面的突出特征，并且第一可移除盖限定了压紧表面延伸通过的间隙孔。
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8.发明申请Method for Treating Pathological Pulmonary Conditions and Bleomycin Associated Pulmonary Fibrosis 有权治疗病理性肺病和博来霉素相关肺纤维化的方法公开(公告)号：US20080311128A1
公开(公告)日：2008-12-18
申请号：US11925330
申请日：2007-10-26
Applicant: William Glass , Lynne Murray
Inventor： William Glass , Lynne Murray
IPC: A61K39/395 , A61P11/00
CPC classification number: C07K16/244
Abstract: Methods for treating pathological pulmonary conditions and bleomycin associated pulmonary fibrosis administer IL-16 antagonists, for example, anti-IL-16 antibodies, to subjects.
Abstract translation: 用于治疗病理性肺病和博来霉素相关肺纤维化的方法将受试者的IL-16拮抗剂，例如抗IL-16抗体。
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