公开(公告)号：US20250136715A1

公开(公告)日：2025-05-01

申请号：US18835795

申请日：2023-02-03

Applicant: GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE ,  MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON

Inventor： Alexandre DETAPPE ,  Xavier PIVOT ,  Pierre COLIAT ,  Olivier TILLEMENT ,  Thomas GREA ,  François LUX ,  Laurent DAVID

IPC: C07K16/32 ,  A61K47/36 ,  C07K16/28

Abstract: A pharmaceutical formulation of a pharmaceutically active protein including an effective amount of a protein or a combination of proteins, a chitosan A and at least one statistic polysaccharide B. Also, a kit including the at least one first container containing the chitosan A and the statistic polysaccharide B and at least one second container containing the protein or combination of proteins. Further, the pharmaceutical formulation or the kit for use in the treatment of cancer, typically breast or gastric cancer.

公开(公告)号：US20240374630A1

公开(公告)日：2024-11-14

申请号：US18291693

申请日：2022-07-28

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

Inventor： Olivier TILLEMENT ,  François LUX ,  Thomas BRICHART ,  Coralie GRANGE ,  Marco NATUZZI ,  Jordyn HOWARD ,  Juan SALAZAR ARIZA ,  Aymeric COUTURIER ,  Fabien ROSSETTI

IPC: A61K31/715 ,  A61K31/395 ,  A61M1/16 ,  A61P39/04

Abstract: The invention relates to a method for treating dialysis water and fluids, in particular for capturing certain toxic metals such as lead, aluminium, chromium, nickel or cadmium, and preventing their passage into the blood of a patient during dialysis, i.e. hemodialysis, hemofiltration or hemodiafiltration. In particular, it relates to a dialysis composition, comprising a polymer with a weight-average molecular weight of 20 kDa and 1000 kDa having at least one chelating agent of at least one toxic exogenous metal such as lead, aluminium, chromium, nickel and cadmium, said polymer being present in a sufficient quantity to be at a concentration comprised between 0.01 mg/L and 10 mg/L when used during a dialysis of a patient.

公开(公告)号：US20250018102A1

公开(公告)日：2025-01-16

申请号：US18782422

申请日：2024-07-24

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

Inventor： Olivier TILLEMENT ,  François LUX ,  Marie VICTOR ,  Denise BECHET ,  Marco NATUZZI ,  Thomas BRICHART

IPC: A61M1/36 ,  A61K47/69 ,  A61M1/16

Abstract: The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.

公开(公告)号：US20240409724A1

公开(公告)日：2024-12-12

申请号：US18698471

申请日：2022-10-03

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： Olivier TILLEMENT ,  François LUX ,  Thomas GREA ,  Coralie GRANGE ,  Axel AIGLE ,  Anouk ROUDIER ,  Laurent DAVID ,  Alexandra MONTEMBAULT ,  Augustin TILLEMENT ,  Renaud PASSIEUX ,  Juan Felipe SALAZAR ARIZA

IPC: C08L5/08 ,  A61K47/36 ,  A61L15/28 ,  A61L15/60 ,  A61L24/00 ,  A61L24/04 ,  A61L31/04 ,  A61L31/14

Abstract: The present invention relates to the field of compositions comprising a polymer bearing a chelating group capable of chelating one or more metals, and to the various uses thereof. In particular, the present invention relates to compositions comprising a copolysaccharide carrying a chelating group, which compositions may be in the form of a gel, as well as to the threads obtained from this gel.

公开(公告)号：US20230173155A1

公开(公告)日：2023-06-08

申请号：US17997763

申请日：2021-04-30

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  INSTITUT GUSTAVE ROUSSY ,  VETAGRO-SUP INSTITUT D'ENSEIGNEMENT SUPÉRIEUR ET DE RECHERCHE

Inventor： Marco NATUZZI ,  Thomas BRICHART ,  Fabien ROSSETTI ,  Matteo MARTINI ,  François LUX ,  Olivier TILLEMENT ,  Jean-Luc PERFETTINI ,  Vanessa LOUZIER ,  Jeanne-Marie BONNET-GARIN ,  Jean-Yves AYOUB

IPC: A61M1/16

CPC classification number: A61M1/1621 ,  A61M1/1654

Abstract: The present invention relates to the field of medical devices, more particularly the field of devices for extracting circulating molecules from the blood of a mammal, and their therapeutic uses, in particular in treating sepsis, cytokine release syndrome and/or any other form of systemic inflammatory response or cytokine shock, caused by bacterial, parasitic, fungal or viral infections, in particular caused by a viral infection, for example coronaviruses with human respiratory tract tropism.

公开(公告)号：US20230346971A1

公开(公告)日：2023-11-02

申请号：US18253694

申请日：2021-11-19

Applicant: NH THERAGUIX ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  MEXBRAIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  HOSPICES CIVILS DE LYON ,  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

Inventor： Olivier TILLEMENT ,  François LUX ,  Delphine VERNOS ,  Claire RODRIGUEZ-LAFRASSE ,  Thomas BRICHART ,  Marco NATUZZI ,  Alain GELOEN ,  Simon CHAMPAGNE ,  Matteo MARTINI ,  Paul ROCCHI

IPC: A61K47/69 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10

CPC classification number: A61K47/6935 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10 ,  A61N2005/1098

Abstract: The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

公开(公告)号：US20230263912A1

公开(公告)日：2023-08-24

申请号：US18007254

申请日：2021-07-29

Applicant: MEXBRAIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  UNIVERSITE CLAUDE BERNARD LYON 1

Inventor： Olivier TILLEMENT ,  François LUX ,  Fabien ROSSETTI ,  Marco NATUZZI ,  Thomas BRICHART ,  Laurent DAVID ,  Paula NUNES DE OLIVEIRA ,  Alexandra MONTEBAULT

IPC: A61K49/12 ,  C08B37/08

CPC classification number: A61K49/128 ,  C08B37/003

Abstract: The invention relates to a statistical polysaccharide with a weight-average molecular weight of between 100 kDa and 1000 kDa of the following formula (I): in which: each Rc independently represents a group containing a chelating agent, each Z independently represents a binder which may be a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said chain able to be either linear or branched and being able to contain one or more unsaturations and being able to contain one or more heteroatoms, preferably chosen from nitrogen, oxygen, sulfur and atoms of the halogen family, x is between 0.005 and 0.7, preferably between 0.05 and 0.7, and preferentially between 0.2 and 0.6, y is between 0.01 and 0.7, preferably between 0.05 and 0.2, the ratio of y/x being greater than or equal to 0.05, preferably greater than or equal to 0.15, and the sum of x+y being greater than or equal to 0.30, preferably greater than or equal to 0.35. The invention also relates to the use of said polysaccharide in a dialysis process in order to capture at least one metal, in an MRI imaging process, in a brachytherapy process or in a process for marking foodstuffs to prevent forgeries.

公开(公告)号：US20220118164A1

公开(公告)日：2022-04-21

申请号：US17425147

申请日：2020-01-24

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

Inventor： Olivier TILLEMENT ,  François LUX ,  Marie VICTOR ,  Denise BECHET ,  Marco NATUZZI ,  Jules Tillement ,  Thomas BRICHART

IPC: A61M1/36 ,  A61K47/69

Abstract: The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.

公开(公告)号：US20210205213A1

公开(公告)日：2021-07-08

申请号：US16955923

申请日：2018-12-21

Applicant: MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

Inventor： François LUX ,  Olivier TILLEMENT ,  Yannick CREMILLEUX ,  Thomas BRICHART ,  Sébastien GROYER

IPC: A61K9/00 ,  A61M1/16 ,  A61K9/51 ,  A61K31/395

Abstract: The present invention relates to the field of medical devices, more particularly to devices for extracting metals from an organism. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of metal homeostasis in the organism, for example neurological diseases.