公开(公告)号：US20240268948A1

公开(公告)日：2024-08-15

申请号：US18567531

申请日：2022-06-07

申请人： UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  HOSPICES CIVILS DE LYON

发明人： Benoit COSSET

IPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/89

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/061

摘要： A fenestrated endoprosthesis of the thoracic aorta including a first mesh of stents, a main tubular endoprosthesis made of fabric, the main tubular endoprosthesis being rigidly attached to the first mesh, and having an arcuate central portion configured to be received in the aortic arch of a patient, the arcuate central portion extending between a first and a second end, each configured to be received respectively in a portion of the ascending or descending aorta, respectively. The fenestrated endoprosthesis further includes a flange also made of fabric and associated with a second mesh of stents, the flange having a substantially frustoconical shape and having a base, the base of the flange being mounted on an opening made in the upper face of the arcuate central portion, the flange being configured to be received at the base of the supra-aortic trunks of the patient.

公开(公告)号：US20240216547A1

公开(公告)日：2024-07-04

申请号：US18558054

申请日：2022-04-28

申请人： UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG ,  CENTRE HOSPITALIER UNIVERSITAIRE

发明人： Philippe GAIN ,  Gilles THURET ,  Emilie COURRIER ,  Zhiguo HE ,  Gilles ULRICH ,  Antoinette DE NICOLA ,  Corantin MAURIN ,  Corentin MARET

IPC分类号： A61K49/00 ,  G01N21/64

CPC分类号： A61K49/0043 ,  A61K49/0073 ,  G01N21/6428 ,  G01N2021/6439

摘要： The invention relates to fluorescein derivative compounds and the use thereof as fluorescent markers. Said markers can be used in particular in biology and in medicine, particularly in the field of ophthalmology. The non-fluorescent fluorescein derivatives are activated in the cell, thereby allowing the detection of living cells as well as the quantification of cell viability by fluorescence, without being toxic to cells.

公开(公告)号：US20240018715A1

公开(公告)日：2024-01-18

申请号：US18032044

申请日：2021-10-15

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite Jean Monnet Saint Etienne ,  La Tannerie Vegetale ,  Université Claude Bernard Lyon 1

发明人： Fanny DELEAGE ,  Yvan CHALAMET

IPC分类号： D06N3/00 ,  C14C3/26

CPC分类号： D06N3/0061 ,  C14C3/26

摘要： The present disclosure relates to a method for the preparation, from a mixture comprising (i) plant proteins, (ii) one or more plant tanning agents, (iii) one or more plasticizers, of a biobased material that may resemble animal leather.

公开(公告)号：US20230134190A1

公开(公告)日：2023-05-04

申请号：US17951231

申请日：2022-09-23

申请人： KERANOVA ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

发明人： Fabrizio ROMANO ,  Aurelien BERNARD ,  Cyril MAUCLAIR ,  Emmanuel BAUBEAU

IPC分类号： A61F9/008

摘要： The present invention relates to an apparatus for cutting-out including a device for treating a L.A.S.E.R. beam generated by a femtosecond laser (1), and positioned downstream from said femtosecond laser, the treatment device comprising: a shaping system (3) positioned on the trajectory of said beam, for modulating the phase of the wave front of the L.A.S.E.R. beam according to a modulation set value calculated for distributing the energy of the L.A.S.E.R. beam in at least two impact points forming a pattern in its focal plane, an optical focusing system (5) downstream from the shaping system, the optical focusing system comprising a concentrator module for focusing the phase-modulated L.A.S.E.R. beam in a focusing plane and a depth-positioning module for displacing the focusing plane into a plurality of cutting-out planes, a sweeping optical scanner (4) positioned between the concentrator module and the depth-positioning module for displacing the pattern in the cutting-out plane in a plurality of positions.

公开(公告)号：US20220162239A1

公开(公告)日：2022-05-26

申请号：US17432510

申请日：2020-02-21

申请人： UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

发明人： JACQUES BODENNEC ,  AMOR BELMEGUENAÏ ,  SELENA BODENNEC ,  LAURENT BEZIN ,  BÉATRICE GEORGES ,  VICTOR BLOT

IPC分类号： C07F9/40 ,  A61P25/08 ,  C07F9/38

摘要： The present invention relates to structured molecular vectors of formula (I), compounds of formula (II) and pharmaceutical compositions comprising such compounds. The invention also relates to such pharmaceutical compositions for use for preventing and/or treating a disease chosen among an inflammatory disease or a disease associated with a cognitive disorder. The invention further relates to such pharmaceutical compositions for use for preventing cognitive decline or restoring cognitive functions altered in brain injuries and/or in traumatic brain injuries and/or in a neuroinflammatory disease, and/or in a neurodegenerative disease.

公开(公告)号：US10980600B2

公开(公告)日：2021-04-20

申请号：US16343369

申请日：2017-09-18

申请人： INSTITUT MINES-TÉLÉCOM ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT-ETIENNE

发明人： David Perrin ,  Stéphane Avril ,  Pierre Badel ,  Jean-Noël Albertini

IPC分类号： A61B34/10 ,  G06T7/12 ,  A61F2/07 ,  G06T7/00 ,  A61B90/00 ,  A61B17/00 ,  A61F2/06

摘要： The method of assisting the production of an implantable unfurlable made to measure device comprises: three-dimensional reconstruction of a complex surface of the cavity in which the device will be implanted; Production of a first finite element mesh of this complex surface; Choosing of generic components of the device; Production of a second finite element mesh of these assembled generic components; Determination of the morphosis parameters for morphosing from the first mesh to a mesh of a set of simple linked volumes which is representative of the part of the cavity, and then deformation of the first mesh by this morphosis; Simulation of a deformation of the second mesh, by inverse morphosis dependent on the determined parameters, to the complex surface, simulating unfurling of the device; Determination of dimensioning of points of interest by projection onto the second deformed mesh; and Generation of a production blueprint plan of the device.

公开(公告)号：US20190282734A1

公开(公告)日：2019-09-19

申请号：US16301908

申请日：2017-05-19

申请人： UNIVERSITE CLAUDE BERNARD LYON I ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET, SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

发明人： Alexandra MONTEMBAULT ,  Laurent DAVID ,  Thierry DELAIR ,  Solene TADIER ,  Laurent GREMILLARD ,  Annelise FAIVRE ,  Florence DESPETIS

IPC分类号： A61L27/46 ,  A61L27/20 ,  A61L27/10

摘要： The invention relates to a product intended for the preparation of an injectable composition containing, separated from one another, at least one first and one second composition(s), and in which: —the first composition, referred to as A, is an aqueous solution of chitosan with a pH in the range extending from 3 to 7, and —the second composition, referred to as B1, corresponds to particles of one or more bioactive glass(es), said product not containing glycerophosphate; and also a process for preparing an injectable composition, the corresponding injectable compositions and devices for packaging a product according to the invention.

公开(公告)号：US10358541B2

公开(公告)日：2019-07-23

申请号：US15537132

申请日：2015-12-21

申请人： ELKEM SILICONES FRANCE SAS ,  Institut National des Sciences Appliquées LYON ,  Université Claude Bernard Lyon 1 ,  Centre national de la recherche scientifique ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

发明人： François Ganachaud ,  Etienne Fleury ,  Daniel Portinha De Almeida ,  Aymeric Genest ,  Emmanuel Pouget

IPC分类号： C08K3/36 ,  A61Q19/00 ,  C08G85/00 ,  C08K5/09 ,  C08K5/10 ,  C08G77/388 ,  A61K8/898 ,  C08G77/38 ,  C08G77/26

摘要： The present invention concerns an organopolysiloxane (A) able to be obtained by the reaction, at a temperature of between 10° C. and 75° C., between—at least one compound (C) chosen from the organic compounds comprising at least one alkene or alkyne functional group, at least one of the substituents of which is an acid functional group and the organic compounds comprising at least one acid functional group and at least one alkene or alkyne functional group, at least one of the substituents of which is an electron-withdrawing group; and—at least one organopolysiloxane (B) chosen from the organopolysiloxanes comprising siloxyl units (I.1) and (I.2) of the following formulae: (I) The present invention also concerns compositions comprising said organopolysiloxanes (A) and the uses thereof. ( I ) Y a ⁢ Z b 1 ⁢ SiO 4 - ( a + b ) 2 ; ( I ⁢ .1 ) Z c 2 ⁢ SiO 4 - c 2 ( I ⁢ .2 )

公开(公告)号：US20150267028A1

公开(公告)日：2015-09-24

申请号：US14438137

申请日：2013-10-23

申请人： COMPAGNIE PLASTIC OMNIUM ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Frederic Viot ,  Philippe Cassagnau ,  Valérie Massardier-Nageotte ,  Flavien Melis

IPC分类号： C08J11/06 ,  B29B9/16 ,  C08J3/12

CPC分类号： C08J11/06 ,  B29B9/06 ,  B29B9/16 ,  B29B17/02 ,  B29B2009/168 ,  B29B2017/0293 ,  B29C47/38 ,  B29K2105/26 ,  B29L2031/3044 ,  C08J3/12 ,  C08J11/08 ,  C08J2300/30 ,  C08J2323/12 ,  Y02W30/622 ,  Y02W30/701 ,  Y10T428/254

摘要： A granulation method that can be used to obtain a polymer from “post-consumer” materials, and a motor vehicle part made from polymers produced by recycling used polymers.

摘要翻译： 可用于从“消费后”材料获得聚合物的造粒方法，以及由通过再循环使用的聚合物制备的聚合物制成的汽车部件。

公开(公告)号：US20150174153A1

公开(公告)日：2015-06-25

申请号：US14414994

申请日：2013-07-16

申请人： UNIVERSITE CLAUDE BERNARD LYON I ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET. SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

发明人： Fatiha Nothias ,  Sylvia Soares ,  Laurent David ,  Alexandra Montembault

IPC分类号： A61K31/722 ,  A61K45/06 ,  A61K9/16

CPC分类号： A61K31/722 ,  A61K9/16 ,  A61K45/06 ,  A61L27/20 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/32 ,  C08L5/08

摘要： The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses.It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.

摘要翻译： 本发明涉及中等尺寸d50的壳聚糖水凝胶微粒，其含量在1〜500μm之间（从数量分布得到），乙酰化程度小于等于20％的壳聚糖，其水凝胶中的浓度在 0.25和5重量％，基于水凝胶的总重量，用于神经元再生和/或神经系统的修复，有利的是中枢神经系统和/或在神经元的嫁接和/或在 治疗神经变性疾病和/或治疗麻痹症。 它还涉及包含与雪旺细胞和/或干细胞和/或营养因子混合的微粒的水性悬浮液的植入物。