摘要:
The present invention provides compounds of formula (I) or salts thereof: having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
摘要:
The present invention provides compounds of formula (I) or salts thereof: having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
摘要:
The invention relates to compounds of formula (I) wherein one of R5 and R6 is hydrogen or R2 and the other is (a) pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the S1P1 receptor.
摘要:
The present invention relates to novel oxadiazole compounds of formula (I) having pharmacological activity, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要:
This invention relates to pyrrolopyrimidine derivatives of formula (I): where R1, X, p, R4, R2 and R3 are as defined herein, and their use as pharmaceuticals.
摘要:
The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial, e.g. to treat pain.
摘要:
The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial, e.g. to treat pain.
摘要:
A disinfectant combination comprises a first supply of a water-soluble hypochlorite; and a second supply of at least one saturated, water-soluble, physiologically acceptable carboxylic acid in solution in an alcoholic solvent which comprises ethanol and optionally water. The combination is used in a method of disinfection, in which a dosed amount of the first supply is mixed with a dosed amount of the second supply to form a disinfectant in situ, and the resulting combined solution, optionally diluted with further water, is applied to a surface or article to be disinfected. In a preferred embodiment, the combination is used for disinfection of endoscopes.
摘要:
Apparatuses and methods for detecting reference marks on magnetic data storage mediums are described herein. In one variation, the apparatus comprises a magnetic servo position demodulator operable to extract information from the magnetic data storage medium utilizing Partial Response/Maximum Likelihood (PRML) technique. Synchronization marks stored within the PRML channel is then detected utilizing a digital filter. For each of the detected synchronization mark, a further refined position of the synchronization mark can be determined utilizing a mathematical prediction model.
摘要:
A device and method is provided wherein a non-extendable strap is attached to the interior of an athletic, or other type of shoe, commencing on the instep side, extending below the user's foot, and ankle, which has been previously fitted with a commercial brace or wrap or taped, which is inserted within the shoe, and the strap is attached within the shoe again on the outstep upper side. The strap element is drawn tight about the user's ankle when the shoe is laced, strapped, or otherwise secured about the user's foot. The strap element extends above the user's ankle, and is pulled taut and affixed to the brace, or wrap, or separately taped, at a position on the outside of the user's lower leg. The device and method of attachment allows the shoe and brace or wrap to act together, as an integrated system, to limit active ankle inversion.