公开(公告)号：US20100290655A1

公开(公告)日：2010-11-18

申请号：US12865523

申请日：2010-03-08

申请人： Keiichi Takeda ,  Yosimasa Simogochi ,  Minoru Tada ,  Makoto Yagi ,  Fumihiro Asayama

发明人： Keiichi Takeda ,  Yosimasa Simogochi ,  Minoru Tada ,  Makoto Yagi ,  Fumihiro Asayama

IPC分类号： H04R25/00

CPC分类号： H04R25/602 ,  H04R2225/61

摘要： A hearing aid (100) comprises a main body (10) and a battery holder (50) that can be opened and closed with respect to the main body by revolving around a revolving shaft. The main body (10) has a lock bar (12) provided so as to traverse the space in which the battery holder (50) is installed, and a protruding portion (14) that protrudes toward this installation space. The battery holder (50) has a first concave portion (62) and a second concave portion (64) that latch the lock bar and the protruding portion.

摘要翻译： 助听器（100）包括主体（10）和电池保持器（50），所述主体（10）和电池保持器（50）能够围绕旋转轴旋转而相对于主体打开和关闭。 主体（10）具有设置成横过安装有电池保持架（50）的空间的锁定杆（12）和向该安装空间突出的突出部（14）。 电池座（50）具有锁定锁定杆和突出部的第一凹部（62）和第二凹部（64）。

公开(公告)号：US07763652B2

公开(公告)日：2010-07-27

申请号：US10521115

申请日：2003-07-11

申请人： Fumie Sato ,  Tohru Tanami ,  Makoto Yagi ,  Naoya Ono

发明人： Fumie Sato ,  Tohru Tanami ,  Makoto Yagi ,  Naoya Ono

IPC分类号： A61K31/215 ,  A61K31/557

CPC分类号： C07C405/0033

摘要： A prostaglandin derivative represented by Formula (I): wherein X is a halogen atom in the α- or β-substitution, Y is an ethylene group, a vinylene group or an ethynylene group, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 straight or branched chain alkyl group or a C4-13 cycloalkylalkyl group, R2 is a hydrogen atom or a CO2R3 group (R3 is a hydrogen atom, a C1-4 straight or branched chain alkyl group or a C2-4 straight or branched chain alkenyl group), n is an integer of 1 to 4 and p is 0, 1 or 2, a pharmaceutically acceptable salt thereof or a hydrate thereof.

摘要翻译： 由式（I）表示的前列腺素衍生物：其中X是α-或/或b-取代基中的卤素原子，Y是亚乙基，亚乙烯基或亚乙炔基，R 1是C 3-10环烷基， 被C 1-4直链或支链烷基或C4-13环烷基烷基取代的C3-10环烷基，R2是氢原子或CO2R3基（R3是氢原子，C1-4直链或支链烷基 基团或C2-4直链或支链烯基），n为1〜4的整数，p为0,1或2，其药学上可接受的盐或其水合物。

公开(公告)号：US07718701B2

公开(公告)日：2010-05-18

申请号：US10493693

申请日：2003-08-07

申请人： Fumie Sato ,  Iwao Arai ,  Norikazu Takano ,  Tohru Tanami ,  Makoto Yagi

发明人： Fumie Sato ,  Iwao Arai ,  Norikazu Takano ,  Tohru Tanami ,  Makoto Yagi

IPC分类号： A01N53/00 ,  C07C59/00 ,  C07C69/74

CPC分类号： A61K31/5575 ,  Y10S514/861 ,  Y10S514/887

摘要： A method of treating atopy-evoked pruritic symptoms by administering a prostaglandin derivative.

摘要翻译： 通过施用前列腺素衍生物治疗特应性诱发的瘙痒症状的方法。

公开(公告)号：US20060094788A1

公开(公告)日：2006-05-04

申请号：US10521115

申请日：2003-07-11

申请人： Fumie Sato ,  Tohru Tanami ,  Makoto Yagi ,  Naoya Ono

发明人： Fumie Sato ,  Tohru Tanami ,  Makoto Yagi ,  Naoya Ono

IPC分类号： A61K31/557 ,  C07C317/20

CPC分类号： C07C405/0033

摘要： A prostaglandin derivative represented by Formula (I): wherein X is a halogen atom in the α- or β-substitution, Y is an ethylene group, a vinylene group or an ethynylene group, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 straight or branched chain alkyl group or a C4-13 cycloalkylalkyl group, R2 is a hydrogen atom or a CO2R3 group (R3 is a hydrogen atom, a C1-4 straight or branched chain alkyl group or a C2-4 straight or branched chain alkenyl group), n is an integer of 1 to 4 and p is 0, 1 or 2, a pharmaceutically acceptable salt thereof or a hydrate thereof.

摘要翻译： 由式（I）表示的前列腺素衍生物：其中X是α-取代或β-取代中的卤素原子，Y是亚乙基，亚乙烯基或亚乙炔基，R 1是 C 3-10环烷基，被C 1-4直链或支链烷基取代的C 3-10环烷基或 C 4-13环烷基烷基，R 2是氢原子或CO 2 R 3 R 3基团（R 3是氢原子，C 1-4烷基直链或支链烷基或C 2-4直链或支链烯基 ），n为1〜4的整数，p为0,1或2，其药学上可接受的盐或其水合物。

公开(公告)号：US08345905B2

公开(公告)日：2013-01-01

申请号：US12933193

申请日：2010-03-08

申请人： Keiichi Takeda ,  Yosimasa Simogochi ,  Minoru Tada ,  Makoto Yagi ,  Fumihiro Asayama

发明人： Keiichi Takeda ,  Yosimasa Simogochi ,  Minoru Tada ,  Makoto Yagi ,  Fumihiro Asayama

IPC分类号： H04R25/00

CPC分类号： H04R25/65 ,  H04R25/602

摘要： An arc-shaped waterproof wall is provided around a shaft to which a hearing aid main body case and a battery case are rotatably attached, and waterproof ribs are provided to the outer periphery of the installation face of the battery case and the hearing aid main body case, which improves the ability to prevent the penetration of moisture while also keep the cost low.

摘要翻译： 助听器主体壳体和电池壳体可旋转地安装在轴的周围设置有弧形防水壁，并且在电池壳体的安装面的外周设有防水肋，助听器主体 的情况下，这提高了防止水分渗透的能力，同时也降低了成本。

公开(公告)号：US08022225B2

公开(公告)日：2011-09-20

申请号：US11659103

申请日：2005-08-04

申请人： Naoya Ono ,  Masakazu Sato ,  Fumiyasu Shiozawa ,  Makoto Yagi ,  Tetsuya Yabuuchi ,  Tetsuo Takayama ,  Hironori Katakai

发明人： Naoya Ono ,  Masakazu Sato ,  Fumiyasu Shiozawa ,  Makoto Yagi ,  Tetsuya Yabuuchi ,  Tetsuo Takayama ,  Hironori Katakai

IPC分类号： C07D249/12 ,  C07D249/08

CPC分类号： C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. [where A represents a sulfur atom, an oxygen atom, a formula —SO— or a formula —SO2—; R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; R2 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or the like; R3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a phenyl group or the like; R5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and R6 represents an alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group].

摘要翻译： 由下式（I）表示的化合物或其药学上可接受的盐具有抑制S1P与其受体Edg-1（S1P1）结合的作用，可用作药物。 [其中A表示硫原子，氧原子，式-SO-或式-SO 2 - ; R1表示氢原子，碳原子数1〜6的烷基等; R2表示碳原子数1〜6的烷基，碳原子数3〜8的环烷基等; R3表示氢原子或碳原子数1〜6的烷基。 R4表示氢原子，碳原子数1〜6的烷基，苯基等; R5表示氢原子或碳原子数1〜6的烷基。 R6表示碳原子数1〜6的烷基，苯基或取代苯基]。

公开(公告)号：US20090131438A1

公开(公告)日：2009-05-21

申请号：US11659103

申请日：2005-08-04

申请人： Naoya Ono ,  Masakazu Sato ,  Fumiyasu Shiozawa ,  Makoto Yagi ,  Tetsuya Yabuuchi ,  Tetsuo Takayama ,  Hironori Katakai

发明人： Naoya Ono ,  Masakazu Sato ,  Fumiyasu Shiozawa ,  Makoto Yagi ,  Tetsuya Yabuuchi ,  Tetsuo Takayama ,  Hironori Katakai

IPC分类号： A61K31/4196 ,  A61P37/00 ,  A61P29/00 ,  A61P17/06 ,  C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/454

CPC分类号： C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. [where A represents a sulfur atom, an oxygen atom, a formula —SO— or a formula —SO2—; R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; R2 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or the like; R3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a phenyl group or the like; R5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and R6 represents an alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group].

摘要翻译： 由下式（I）表示的化合物或其药学上可接受的盐具有抑制S1P与其受体Edg-1（S1P1）结合的作用，可用作药物。 [其中A表示硫原子，氧原子，式-SO-或式-SO 2 - ; R1表示氢原子，碳原子数1〜6的烷基等; R2表示碳原子数1〜6的烷基，碳原子数3〜8的环烷基等; R3表示氢原子或碳原子数1〜6的烷基。 R4表示氢原子，碳原子数1〜6的烷基，苯基等; R5表示氢原子或碳原子数1〜6的烷基。 R6表示碳原子数1〜6的烷基，苯基或取代苯基]。

公开(公告)号：US06613932B1

公开(公告)日：2003-09-02

申请号：US10070752

申请日：2002-03-11

申请人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi ,  Hitomi Hirano

发明人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi ,  Hitomi Hirano

IPC分类号： C07C6974

CPC分类号： C07C405/00

摘要： A prostaglandin derivative represented by the formula: [wherein X is CH2, O or S(O)q1, Y is an ethylene group, a vinylene group, an ethynylene group, O(CH2)t1 or S(O)q2(CH2)t1, Z is an ethylene group, a vinylene group or an ethynylene group, R1 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, R2 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-5 alkyl group, a hydroxy-C1-5 alkyl group, a halogeno-C1-5 alkyl group, a C1-5 alkoxy-C1-5 alkyl group, a C2-4 alkoxycarbonyl-C1-5 alkyl group, a carboxyl-C1-5 alkyl group, a cyano-C1-5 alkyl group, a C1-5 alkyl group substituted with a group represented by the formula: —NR7R8, an acyl group, a group represented by the formula: —(CH2)t2CH(NH2)COOR9, etc., and R3 is a hydrogen atom, a C1-10 alkyl group, etc.], a pharmaceutically acceptable salt thereof or a hydrate thereof. Novel prostaglandin derivatives of the present invention have an excellent action in inhibiting the growth of vascular smooth muscle, and are useful as drugs for prevention or treatment of the restenosis after PTCA, etc.

摘要翻译： 由下式表示的前列腺素衍生物[其中X为CH 2，O或S（O）q1，Y为亚乙基，亚乙烯基，亚乙炔基，O（CH 2）t 1或S（O）q 2（CH 2） t1，Z是亚乙基，亚乙烯基或亚乙炔基，R1是氢原子，C1-10烷基或C3-10环烷基，R2是C1-10烷基，C2-10烯基 基团，C 2-10炔基，C 3-10环烷基，C 1-5烷基-C 3-10环烷基，C 3-10环烷基-C 1-5烷基，羟基-C 1-5烷基， 卤代C 1-5烷基，C 1-5烷氧基-C 1-5烷基，C 2-4烷氧基羰基-C 1-5烷基，羧基-C 1-5烷基，氰基-C 1-5烷基， 由下式表示的C1-5烷基：-NR7R8，酰基，由下式表示的基团： - （CH2）t2CH（NH2）COOR9等，R3为氢原子， C 1-10烷基等]，其药学上可接受的盐或其水合物。本发明的新型前列腺素衍生物 在抑制血管平滑肌生长中具有优异的作用，可用作预防或治疗PTCA等后再狭窄的药物。

公开(公告)号：US06482990B1

公开(公告)日：2002-11-19

申请号：US10070154

申请日：2002-03-04

申请人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi

发明人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi

IPC分类号： C07L40500

CPC分类号： C07C405/00 ,  C07C405/0025

摘要： A prostaglandin analog represented by Formula (I): [wherein A is an ethylene group, a vinylene group or an ethynylene group, Y1 and Y2 are the same or different, and each a hydrogen atom, a halogen atom, a cyano group, —CONR3R4 (wherein R3 and R4 are the same or different, and each a hydrogen atom or a C1-6 alkyl group, or R3 and R4 together with the nitrogen atom to which they are attached form a C4-8 cyclic amine), a C1-3 aminoalkyl group, a C1-6 hydroxyalkyl group, NR5R6 (wherein R5 and R6 are the same or different, and each a hydrogen atom or a C1-6 alkyl group), a hydroxyl group, a C1-6 alkoxy group, a C1-9 alkyl group, a C1-6 alkyl group substituted with halogen(s), a C1-5 acyl group or COOR7 (wherein R7 is a hydrogen atom, a C1-6 alkyl group or a phenyl group), R1 and R2 are the same or different, and each a hydrogen atom, a halogen atom, a C1-9 alkyl group or a C1-6 alkyl group substituted with halogen(s), m is an integer of 0 to 6, and n is an integer of 0 to 3], a pharmaceutically acceptable salt thereof or a hydrate thereof.

摘要翻译： 由式（I）表示的前列腺素类似物：[其中A是亚乙基，亚乙烯基或亚乙炔基，Y1和Y2相同或不同，氢原子，卤素原子，氰基 - CONR 3 R 4（其中R 3和R 4相同或不同，并且各自为氢原子或C 1-6烷基，或者R 3和R 4与它们所连接的氮原子一起形成C 4-8环胺），C 1 -3氨基烷基，C1-6羟基烷基，NR5R6（其中R5和R6相同或不同，各自为氢原子或C1-6烷基），羟基，C1-6烷氧基， C1-9烷基，被卤素取代的C1-6烷基，C1-5酰基或COOR7（其中R7是氢原子，C1-6烷基或苯基），R1和R2 各自为氢原子，卤素原子，C1-9烷基或被卤素取代的C1-6烷基，m为0〜6的整数，n为整数 0〜3]，药物 其可接受的盐或其水合物。

公开(公告)号：US20120039498A1

公开(公告)日：2012-02-16

申请号：US13266580

申请日：2011-05-23

申请人： Shinichi Yasui ,  Makoto Yagi

发明人： Shinichi Yasui ,  Makoto Yagi

IPC分类号： H04R25/00

CPC分类号： H01M2/1044 ,  H01M12/06 ,  H04R25/602 ,  H04R2460/17

摘要： This auxiliary member for a hearing aid comprises a main body case (1) having an insertion hole (3) of a hearing aid (2) on a top face, a hearing aid accommodating space (1A) provided to the portion corresponding to the insertion hole (3) inside this main body case (1), a holding member (15) that holds the hearing aid (2) accommodated in this hearing aid accommodating space (1A), a manipulation component (11) for manipulating this holding member (15), and an opening component (16) for opening a battery case (5) of the hearing aid (2) accommodated in the hearing aid accommodating space (1A).

摘要翻译： 用于助听器的辅助构件包括：主体壳体（1），其具有在顶面上的助听器（2）的插入孔（3）;助听器容纳空间（1A），设置在与插入件对应的部分 在该主体壳体（1）内的孔（3），容纳在该助听器容纳空间（1A）中的助听器（2）的保持构件（15），用于操纵该保持构件 以及用于打开容纳在助听器容纳空间（1A）中的助听器（2）的电池壳体（5）的开口部件（16）。