公开(公告)号：US20070167365A1

公开(公告)日：2007-07-19

申请号：US11580497

申请日：2006-10-13

申请人： Richard Beliveau ,  Michel Demeule ,  Joseph Yang ,  Malcolm Kennard ,  Reinhard Gabathuler

发明人： Richard Beliveau ,  Michel Demeule ,  Joseph Yang ,  Malcolm Kennard ,  Reinhard Gabathuler

IPC分类号： A61K38/55 ,  C12N9/24

CPC分类号： A61K38/40 ,  A61K38/177 ,  A61K47/644 ,  A61K2039/505 ,  C07K16/40

摘要： This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by, providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases.

摘要翻译： 本发明提供了治疗性或活性剂与黑色素转铁蛋白或黑色素转铁蛋白受体的其它配体，黑色素转铁蛋白受体调节剂以及调节血脑屏障转运的相关组合物和方法的缀合物，提供了筛选和选择此类缀合物，配体和 体外和体内的调节剂，以及这种缀合物，调节剂和配体在诊断和治疗疾病中的使用方法，特别是包括中枢神经系统或溶酶体贮积病的疾病。

公开(公告)号：US5981194A

公开(公告)日：1999-11-09

申请号：US520933

申请日：1995-08-31

申请人： Wilfred A. Jefferies ,  Patrick L. McGeer ,  Sylvia Rothenberger ,  Michael R. Food ,  Tatsuo Yamada ,  Malcolm Kennard

发明人： Wilfred A. Jefferies ,  Patrick L. McGeer ,  Sylvia Rothenberger ,  Michael R. Food ,  Tatsuo Yamada ,  Malcolm Kennard

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K51/08 ,  C07K14/79 ,  C12N5/02 ,  G01N33/53 ,  G01N33/68 ,  C07K16/00

CPC分类号： C07K14/79 ,  G01N33/6896 ,  A61K2121/00 ,  A61K2123/00 ,  A61K38/00 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The invention related to a GPI-anchored p97 and a soluble form of p97 and derivatives thereof and methods for preparing the same. Methods of using p97 in modulating iron transport, in the delivery of therapeutic agents, and in the treatment of conditions involving disturbances in iron metabolism are described. The treatment and diagnosis of Alzheimer's Disease in view of the finding that p97 and transferrin receptor are markers for microglial cells associated with senile plaques are also described.

公开(公告)号：US06455494B1

公开(公告)日：2002-09-24

申请号：US09285040

申请日：1999-04-01

申请人： Wilfred A. Jefferies ,  Patrick L. McGeer ,  Sylvia Rothenberger ,  Michael R. Food ,  Tatsuo Yamada ,  Malcolm Kennard

发明人： Wilfred A. Jefferies ,  Patrick L. McGeer ,  Sylvia Rothenberger ,  Michael R. Food ,  Tatsuo Yamada ,  Malcolm Kennard

IPC分类号： A61K3800

CPC分类号： C07K14/79 ,  A61K38/00 ,  A61K2121/00 ,  A61K2123/00 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The invention related to a GPI-anchored p97 and a soluble form of p97 and derivatives thereof and methods for preparing the same. Methods of using p97 in modulating iron transport, in the delivery of therapeutic agents, and in the treatment of conditions involving disturbances in iron metabolism are described. The treatment and diagnosis of Alzheimer's Disease in view of the finding that p97 and transferrin receptor are markers for microglial cells associated with senile plaques are also described.

摘要翻译： 本发明涉及GPI锚定的p97和可溶性形式的p97及其衍生物及其制备方法。 描述了使用p97调节铁转运，递送治疗剂以及治疗涉及铁代谢紊乱的病症的方法。 鉴于p97和转铁蛋白受体是与老年斑相关的小胶质细胞的标志物的发现，阿尔茨海默病的治疗和诊断也被描述。