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公开(公告)号：US5981194A
公开(公告)日：1999-11-09
申请号：US520933
申请日：1995-08-31
申请人： Wilfred A. Jefferies , Patrick L. McGeer , Sylvia Rothenberger , Michael R. Food , Tatsuo Yamada , Malcolm Kennard
发明人： Wilfred A. Jefferies , Patrick L. McGeer , Sylvia Rothenberger , Michael R. Food , Tatsuo Yamada , Malcolm Kennard
IPC分类号： G01N33/50 , A61K38/00 , A61K51/08 , C07K14/79 , C12N5/02 , G01N33/53 , G01N33/68 , C07K16/00
CPC分类号： C07K14/79 , G01N33/6896 , A61K2121/00 , A61K2123/00 , A61K38/00 , G01N2333/4709 , G01N2800/2821
摘要： The invention related to a GPI-anchored p97 and a soluble form of p97 and derivatives thereof and methods for preparing the same. Methods of using p97 in modulating iron transport, in the delivery of therapeutic agents, and in the treatment of conditions involving disturbances in iron metabolism are described. The treatment and diagnosis of Alzheimer's Disease in view of the finding that p97 and transferrin receptor are markers for microglial cells associated with senile plaques are also described.
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2.发明授权公开(公告)号：US06455494B1
公开(公告)日：2002-09-24
申请号：US09285040
申请日：1999-04-01
申请人： Wilfred A. Jefferies , Patrick L. McGeer , Sylvia Rothenberger , Michael R. Food , Tatsuo Yamada , Malcolm Kennard
发明人： Wilfred A. Jefferies , Patrick L. McGeer , Sylvia Rothenberger , Michael R. Food , Tatsuo Yamada , Malcolm Kennard
IPC分类号： A61K3800
CPC分类号： C07K14/79 , A61K38/00 , A61K2121/00 , A61K2123/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention related to a GPI-anchored p97 and a soluble form of p97 and derivatives thereof and methods for preparing the same. Methods of using p97 in modulating iron transport, in the delivery of therapeutic agents, and in the treatment of conditions involving disturbances in iron metabolism are described. The treatment and diagnosis of Alzheimer's Disease in view of the finding that p97 and transferrin receptor are markers for microglial cells associated with senile plaques are also described.
摘要翻译： 本发明涉及GPI锚定的p97和可溶性形式的p97及其衍生物及其制备方法。 描述了使用p97调节铁转运，递送治疗剂以及治疗涉及铁代谢紊乱的病症的方法。 鉴于p97和转铁蛋白受体是与老年斑相关的小胶质细胞的标志物的发现，阿尔茨海默病的治疗和诊断也被描述。
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公开(公告)号：US10966945B2
公开(公告)日：2021-04-06
申请号：US13195216
申请日：2011-08-01
申请人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
发明人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
摘要： This patent pertains to selective inhibition of assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by the membrane attack complex. These diseases include, but are not limited to, Alzheimer disease, age related macular degeneration, and atherosclerosis.
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4.发明申请Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex 审中-公开选择性抑制由aurin三羧酸合成复合物的低分子量组分补体的膜攻击复合物公开(公告)号：US20130035388A1
公开(公告)日：2013-02-07
申请号：US13195216
申请日：2011-08-01
申请人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
发明人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
IPC分类号： A61K31/235 , A61P27/02 , A61P25/28 , A61P9/10 , C12N5/071 , A61K31/194
CPC分类号： A61K31/194
摘要： This patent pertains to selective inhibition of assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by the membrane attack complex. These diseases include, but are not limited to, Alzheimer disease, age related macular degeneration, and atherosclerosis.
摘要翻译： 该专利涉及通过使用小于1kDa分子量的无色三羧酸合成复合物（ATAC）及其衍生物来选择性抑制补体膜复制物的组装。 它还涉及使用这些材料来治疗人类病症，其中通过膜侵袭复合物有宿主组织的自我破坏的证据。 这些疾病包括但不限于阿尔茨海默病，年龄相关性黄斑变性和动脉粥样硬化。
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公开(公告)号：US5532219A
公开(公告)日：1996-07-02
申请号：US042658
申请日：1993-04-05
IPC分类号： A61K31/145 , A61K31/185 , A61K31/426 , A61K31/13
CPC分类号： A61K31/426 , A61K31/145 , A61K31/185
摘要： This invention pertains to the novel use of 4,4'-diaminodiphenylsulfone and its didextrose sulfonate derivative and other closely related sulfones in the prevention and treatment of dementia (Alzheimer's disease). A method of preventing and treating dementia in a human being suffering from dementia which comprises administering to the human being a therapeutic amount of a substance selected from the group consisting of 4,4'-diaminodiphenylsulfone, its didextrose sulfonate derivative, and sulfoxone, sulfetrone and thiazolsulfone, and therapeutically acceptable salts thereof.
摘要翻译： 本发明涉及4,4'-二氨基二苯砜及其二葡萄糖磺酸衍生物及其它密切相关的砜在预防和治疗痴呆症（阿尔茨海默病）中的新用途。 一种预防和治疗患有痴呆症的人的痴呆症的方法，其包括向所述人施用治疗量的选自下组的物质：4,4'-二氨基二苯基砜，其二葡聚糖磺酸酯衍生物和砜酮，磺基和 噻唑砜及其可治疗的盐。
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公开(公告)号：US5192753A
公开(公告)日：1993-03-09
申请号：US689499
申请日：1991-04-23
申请人： Patrick L. McGeer , Joseph Rogers , John Sibley , Edith McGeer
发明人： Patrick L. McGeer , Joseph Rogers , John Sibley , Edith McGeer
IPC分类号： A61K45/00 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/38 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/54 , A61K31/60 , A61P25/28 , A61P29/00
CPC分类号： A61K31/621 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/38 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/54 , A61K31/60
摘要： This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inhibit prostaglandin synthesis in the human being.
摘要翻译： 本发明涉及抗风湿关节炎药物在治疗痴呆症中的新用途。 一种治疗人类痴呆症的方法，其包括向人体施用治疗量的非甾体抗炎药（NSAID），其具有抑制人类前列腺素合成的能力。
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7.发明申请Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex 审中-公开选择性抑制补体和C3转化酶的膜攻击复合物由低分子量成分的三元羧酸合成复合物公开(公告)号：US20130035392A1
公开(公告)日：2013-02-07
申请号：US13541535
申请日：2012-07-03
申请人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
发明人： Patrick L. McGeer , Moonhee Lee , Jian-Ping Guo , Claudia Schwab
CPC分类号： A61K31/194 , Y02A50/411
摘要： It pertains to selective inhibition of C3 convertase of the alternative pathway of complement as well as the previously claimed assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by C3 convertase activation of the alternative complement pathway, or the membrane attack complex, or both pathways. These diseases include, but are not limited to, paroxysmal nocturnal hemoglobinemia, rheumatoid arthritis, multiple sclerosis, malaria infection, Alzheimer disease, age related macular degeneration, and atherosclerosis.
摘要翻译： 它涉及选择性抑制补体途径的C3转化酶的选择性抑制，以及通过使用小于1kDa分子量形式的神经元三羧酸合成复合物（ATAC）的先前要求的补体膜攻击复合物的组合，以及 他们的衍生品。 它还涉及使用这些材料来治疗人类病症，其中有证据表明通过C3转化酶激活替代补体途径或膜攻击复合物或两种途径的宿主组织的自身破坏。 这些疾病包括但不限于阵发性夜间血红蛋白血症，类风湿性关节炎，多发性硬化，疟疾感染，阿尔茨海默病，年龄相关性黄斑变性和动脉粥样硬化。
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公开(公告)号：US5776946A
公开(公告)日：1998-07-07
申请号：US520211
申请日：1995-08-28
IPC分类号： A61K31/5513 , A61K31/47
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/5513
摘要： Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline and benzodiazepine derivatives, such as PK 11195. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are provided. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.
摘要翻译： 与周边苯并二氮杂受体高亲和力结合的化合物可用作抗炎剂。 这样的化合物包括异喹啉和苯并二氮杂衍生物，例如PK11195。提供了一种用这些化合物治疗哺乳动物炎性病症的方法。 提供包含这些化合物的药物组合物。 提供了一种用于鉴定治疗有效治疗炎性病症的化合物的方法。
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