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公开(公告)号:US08741917B2
公开(公告)日:2014-06-03
申请号:US13144675
申请日:2010-01-15
申请人: Edmond J. LaVoie , Ajit Parhi , Daniel S. Pilch , Malvika Kaul
发明人: Edmond J. LaVoie , Ajit Parhi , Daniel S. Pilch , Malvika Kaul
IPC分类号: A01N43/42 , A61K31/44 , C07D221/22 , C07D221/18
CPC分类号: C07D221/12
摘要: The present invention provides compounds of formula I: formula (I) wherein X1-X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.
摘要翻译: 本发明提供式I化合物:式(I)其中X1-X4和R1-R12具有说明书中定义的任何值,以及其盐和前药,其抑制与细菌细胞分裂相关的主要分子机制, 增殖,从而可用于治疗和/或预防细菌感染。 本发明还提供包含这些化合物的组合物以及使用这些化合物抑制细菌细胞分裂和增殖并治疗细菌感染的方法。
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公开(公告)号:US20120059026A1
公开(公告)日:2012-03-08
申请号:US13266740
申请日:2010-04-30
申请人: Edmond J. LaVoie , Daniel S. Pilch , Ajit Parhi , Malvika Kaul
发明人: Edmond J. LaVoie , Daniel S. Pilch , Ajit Parhi , Malvika Kaul
IPC分类号: A61K31/472 , A01N43/42 , A61P31/04 , A61K31/473 , A01P1/00 , C07D217/02 , C07D221/18
CPC分类号: C07D455/03 , C07D217/02 , C07D217/10 , C07D217/12 , C07D405/04
摘要: The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1-R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.
摘要翻译: 本发明提供式(I)化合物或其盐或前药,其中Y,W,Z,Z 1,Z 2,Z 3,Z 4和R 1 -R 12具有说明书中描述的任何值,以及 组合物,其包含式(I)化合物。 这些化合物可用作抗菌剂。
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公开(公告)号:US20120022061A1
公开(公告)日:2012-01-26
申请号:US13144675
申请日:2010-01-15
申请人: Edmond J. LaVoie , Ajit Parhi , Daniel S. Pilch , Malvika Kaul
发明人: Edmond J. LaVoie , Ajit Parhi , Daniel S. Pilch , Malvika Kaul
IPC分类号: A61K31/5377 , C07D221/18 , C07D405/10 , C07D413/10 , C07D401/10 , A61P31/04 , A61K31/4355 , A61K31/435 , A01N43/90 , A01N43/42 , A01N43/84 , A01P1/00 , C07D491/056 , C07D491/153
CPC分类号: C07D221/12
摘要: The present invention provides compounds of formula I: formula (I) wherein X1-X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.
摘要翻译: 本发明提供式I化合物:式(I)其中X1-X4和R1-R12具有说明书中定义的任何值,以及其盐和前药,其抑制与细菌细胞分裂相关的主要分子机制, 增殖,从而可用于治疗和/或预防细菌感染。 本发明还提供包含这些化合物的组合物以及使用这些化合物抑制细菌细胞分裂和增殖并治疗细菌感染的方法。
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公开(公告)号:US06613569B1
公开(公告)日:2003-09-02
申请号:US09979681
申请日:2002-03-05
IPC分类号: C12N508
CPC分类号: C12N7/00 , C07K14/005 , C12N15/86 , C12N2740/16041 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2830/002 , C12N2830/50 , C12N2840/20 , C12N2840/203
摘要: Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of unregulated expression of certain envelope proteins and lentiviral proteins. Various embodiments of the cell lines are disclosed, which are suitable for different purposes that range from in vitro screening assays to gene therapy in vivo.
摘要翻译: 公开了用于生产慢病毒载体的新型包装细胞系。 细胞系利用蜕皮激素诱导系统进行病毒生产,从而避免某些包膜蛋白和慢病毒蛋白的不受调节表达的细胞毒作用。 公开了细胞系的各种实施方案,其适用于从体外筛选测定到体内基因治疗的不同目的。
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