公开(公告)号：US20120301450A1

公开(公告)日：2012-11-29

申请号：US13577314

申请日：2011-02-09

申请人： Hirokuni Miyamoto ,  Hiroaki Kodama ,  Takumi Nishiuchi ,  Teruo Matsushita ,  Hisashi Miyamoto ,  Sankichi Horiuchi ,  Manami Seta ,  Kenichi Mori ,  Masahira Hattori ,  Kazuo Ogawa

发明人： Hirokuni Miyamoto ,  Hiroaki Kodama ,  Takumi Nishiuchi ,  Teruo Matsushita ,  Hisashi Miyamoto ,  Sankichi Horiuchi ,  Manami Seta ,  Kenichi Mori ,  Masahira Hattori ,  Kazuo Ogawa

IPC分类号： A61K35/74 ,  A61P37/04 ,  A61P3/00

CPC分类号： A61K35/741 ,  C12R1/01 ,  C12R1/07

摘要： To provide a mixture, a dissolving solution and a pharmaceutical agent, which contain a thermophilic microorganism to make it possible to regulate a mucous membrane immune system gene cluster and metabolism-related gene clusters of the intestines and the liver. Each of them is prepared by fermentation of an organic material containing a thermophilic microorganism at a temperature of 50° C. or more and 90° C. or less. By being administered to the animal, it regulates at least one of a mucous membrane immune system gene cluster, a metabolism-related gene cluster in the intestines, and a metabolism-related gene cluster in the liver of the animal. The microorganism includes at least one species of the genus Bacillus, Oceanobacillus, Paenibacillus, Anoxybacillus, Lysinibacillus, Methanopyrus, Geogemma, Pyrolobus, Pyrodictium, Hyperthermus, Pyrococcus, Pyrobaculum, Thermococcus, Aeropyrum, Aquifex, Thermotoga, Thermodesulfobacterium, Thermus, Geobacillus, and Thermomyces.

摘要翻译： 提供含有嗜热微生物的混合物，溶解溶液和药剂，以便调节粘膜免疫系统基因簇和代谢相关的肠和肝的基因簇。 它们各自通过在50℃以上且90℃以下的温度下发酵含有嗜热微生物的有机材料来制备。 通过施用于动物，其调节粘膜免疫系统基因簇，肠中代谢相关基因簇和动物肝脏中代谢相关基因簇中的至少一种。 微生物包括芽孢杆菌属，海洋芽孢杆菌属，芽孢杆菌属，厌氧杆菌属，嗜热芽孢杆菌属，甲烷us霉，地热质属，火焰菌属，火炬菌属，热原，热球菌属，火腿菌属，热球菌属，艾氏梭菌属，Aquifex菌，热酵母菌，热链球菌属，栖热菌属，土芽孢杆菌属和Thermomyces 。