公开(公告)号：US08936713B2

公开(公告)日：2015-01-20

申请号：US12965680

申请日：2010-12-10

申请人： James Iain Rodgers ,  Leanne Mills ,  Marco Cardosi ,  Chris Leach ,  James Moffat

发明人： James Iain Rodgers ,  Leanne Mills ,  Marco Cardosi ,  Chris Leach ,  James Moffat

IPC分类号： G01N27/327

CPC分类号： G01N27/3274

摘要： Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.

摘要翻译： 本文描述和示出了具有仪表和测试条的一个示例性方法和测量系统。 测试条具有第一工作电极，参考电极和第二工作电极。 在该方法中，使用来自已知第一电流和已知第二电流的可接受的填充数据来预测在测试序列期间接近第二时间段（对于给定批次的测试条）的估计的第二电流。 然后在实际测试期间，将接近第二时间间隔的估计的第二电流与接近第二时间间隔的测量的实际第二电流进行比较，以确定测量的实际第二电流是否基本上等于或在与估计的 以确定测试条中的生理液体样本的足够体积。

公开(公告)号：US08545693B2

公开(公告)日：2013-10-01

申请号：US12875887

申请日：2010-09-03

申请人： David McColl ,  Adam Craggs ,  Stephen MacKintosh ,  Steve Blythe ,  Marco Cardosi

发明人： David McColl ,  Adam Craggs ,  Stephen MacKintosh ,  Steve Blythe ,  Marco Cardosi

IPC分类号： G01N33/50 ,  C12Q1/00

CPC分类号： G01N27/3274 ,  G01N27/3271

摘要： Described and illustrated herein are systems and exemplary methods of operating a multianalyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a test voltage between a reference electrode and a first working electrode; measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip; estimating a hematocrit-corrected analyte concentration from the first, second and third test currents; and displaying the hematocrit-corrected analyte concentration.

摘要翻译： 本文描述和示出了操作具有仪表和测试条的多分析仪测量系统的系统和示例性方法。 在一个实施例中，该方法可以通过在参考电极和第一工作电极之间施加测试电压来实现; 将含有分析物的血液样本的测量仪在工作电极上测量第一测试电流，第二测试电流和第三测试电流; 从第一，第二和第三测试电流估计血细胞比容校正的分析物浓度; 并显示血细胞比容校正的分析物浓度。

公开(公告)号：US20060069211A1

公开(公告)日：2006-03-30

申请号：US10957441

申请日：2004-09-30

申请人： Zuifang Liu ,  James Rodgers ,  Geoffrey Lillie ,  Marco Cardosi

发明人： Zuifang Liu ,  James Rodgers ,  Geoffrey Lillie ,  Marco Cardosi

IPC分类号： C08F271/02

CPC分类号： C12Q1/004

摘要： Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors include a hydrophilic polymer (such as a hydrophilic polymer backbone) with ionic portions (e.g., cationic monomers incorporated in the hydrophilic polymer backbone) and a plurality of attached redox mediators. The redox mediators can be, for example, covalently attached to the hydrophilic polymer in a pendant manner. An exemplary cationic hydrophilic high molecular weight redox polymer is synthesized by co-polymerization of a hydrophilic acrylamide monomer, [2-(acryloyloxy)ethyl]trimethyl ammonium chloride and vinyl ferrocene.

摘要翻译： 用于酶电化学传感器的离子型亲水性高分子量氧化还原聚合物包括具有离子部分的亲水性聚合物（例如亲水性聚合物主链）（例如并入亲水性聚合物主链中的阳离子单体）和多个附着的氧化还原介体。 氧化还原介体可以例如以悬挂的方式与亲水性聚合物共价连接。 通过亲水丙烯酰胺单体[2-（丙烯酰氧基）乙基]三甲基氯化铵和乙烯基二茂铁的共聚合来合成示例性的阳离子亲水性高分子量氧化还原聚合物。

公开(公告)号：US20130284609A1

公开(公告)日：2013-10-31

申请号：US13460236

申请日：2012-04-30

申请人： Zuifang LIU ,  Steven Setford ,  Marco Cardosi

发明人： Zuifang LIU ,  Steven Setford ,  Marco Cardosi

IPC分类号： G01N27/327 ,  G01N33/50

CPC分类号： C12Q1/004 ,  C12Q1/005

摘要： A nicotinamide adenine dinucleotide (NAD) polymeric coenzyme for use in enzymatic electrochemical-based sensors includes NAD moieties covalently bound as pendent groups to a polymer backbone. An enzymatic electrochemical-based biosensor includes nicotinamide adenine dinucleotide (NAD) polymeric coenzyme, a polymeric electron transfer agent (e.g., polymeric ferrocene) at least one working electrode, and at least one reference electrode.

摘要翻译： 用于基于酶电化学的传感器中的烟酰胺腺嘌呤二核苷酸（NAD）聚合辅酶包括与聚合物主链共价结合作为侧基的NAD部分。 基于酶电化学的生物传感器包括烟酰胺腺嘌呤二核苷酸（NAD）聚合辅酶，聚合电子转移剂（例如聚合二茂铁）至少一个工作电极和至少一个参比电极。

公开(公告)号：US20110144915A1

公开(公告)日：2011-06-16

申请号：US12965680

申请日：2010-12-10

申请人： James Iain RODGERS ,  Leanne MILLS ,  Marco CARDOSI ,  Chris LEACH ,  James MOFFAT

发明人： James Iain RODGERS ,  Leanne MILLS ,  Marco CARDOSI ,  Chris LEACH ,  James MOFFAT

IPC分类号： G06F19/00

CPC分类号： G01N27/3274

摘要： Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.

摘要翻译： 本文描述和示出了具有仪表和测试条的一个示例性方法和测量系统。 测试条具有第一工作电极，参考电极和第二工作电极。 在该方法中，使用来自已知第一电流和已知第二电流的可接受的填充数据来预测在测试序列期间接近第二时间段（对于给定批次的测试条）的估计的第二电流。 然后在实际测试期间，将接近第二时间间隔的估计的第二电流与接近第二时间间隔的测量的实际第二电流进行比较，以确定测量的实际第二电流是否基本上等于或在与估计的 以确定测试条中的生理液体样本的足够体积。

公开(公告)号：US20110073494A1

公开(公告)日：2011-03-31

申请号：US12875887

申请日：2010-09-03

申请人： David MCCOLL ,  Adam Craggs ,  Stephen MacKintosh ,  Steve Blythe ,  Marco Cardosi

发明人： David MCCOLL ,  Adam Craggs ,  Stephen MacKintosh ,  Steve Blythe ,  Marco Cardosi

IPC分类号： G01N27/26

CPC分类号： G01N27/3274 ,  G01N27/3271

摘要： Described and illustrated herein are systems and exemplary methods of operating a multianalyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a test voltage between a reference electrode and a first working electrode; measuring a first test current, a second test current and a third test current at the working electrode with the meter after a blood sample containing an analyte is applied to the test strip; estimating a hematocrit-corrected analyte concentration from the first, second and third test currents; and displaying the hematocrit-corrected analyte concentration.

摘要翻译： 本文描述和示出了操作具有仪表和测试条的多分析仪测量系统的系统和示例性方法。 在一个实施例中，该方法可以通过在参考电极和第一工作电极之间施加测试电压来实现; 将含有分析物的血液样本的测量仪在工作电极上测量第一测试电流，第二测试电流和第三测试电流; 从第一，第二和第三测试电流估计血细胞比容校正的分析物浓度; 并显示血细胞比容校正的分析物浓度。

公开(公告)号：US4898816A

公开(公告)日：1990-02-06

申请号：US027979

申请日：1987-03-19

申请人： Anthony P. F. Turner ,  Ann Swain ,  Graham Ramsay ,  Marco Cardosi ,  Bernard H. Schneider

发明人： Anthony P. F. Turner ,  Ann Swain ,  Graham Ramsay ,  Marco Cardosi ,  Bernard H. Schneider

IPC分类号： C12Q1/00 ,  C12Q1/02

CPC分类号： C12Q1/004 ,  C12Q1/02

摘要： 1,4-Benzoquinone can act as a mediator of electron transfer in bioelectrochemical cells for measuring microbiological activity in a sample. In combination with ferricyanide it can provide a surprisingly high level of mediator activity with many microorganisms, and a more even response when the sample may contain a mixture of microorganisms.

摘要翻译： 1,4-苯醌可用作生物电化学电池中电子转移的介质，用于测量样品中的微生物活性。 与铁氰化物一起，它可以提供令人惊讶的高水平的介质活性与许多微生物，当样品可能含有微生物的混合物时，反应更加均匀。

公开(公告)号：US20130220835A1

公开(公告)日：2013-08-29

申请号：US13408970

申请日：2012-02-29

申请人： Zuifang LIU ,  Louise SIMPSON ,  Marco CARDOSI

发明人： Zuifang LIU ,  Louise SIMPSON ,  Marco CARDOSI

IPC分类号： G01N27/327 ,  G01N33/66 ,  G01N33/50 ,  B82Y30/00

CPC分类号： C12Q1/001

摘要： A biosensor (such as an electrochemical-based analytical test strip configured for the determination of glucose in a whole blood sample) includes a substrate, an electrode disposed on the substrate and a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles. Aqueous compositions useful in, for example, the manufacturing of such biosensors include polyVDAT nanoparticles and water with the polyVDAT nanoparticles being present as a dispersion in the water. A method for determining an analyte in a bodily fluid sample containing uric acid includes applying a bodily fluid sample containing uric acid to a biosensor such that the bodily fluid sample comes into contact with a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles and determining the analyte based on an electronic signal produced by the biosensor.

摘要翻译： 生物传感器（例如，配置成用于测定全血样品中的葡萄糖的基于电化学的分析测试条）包括基底，设置在基底上的电极和含有聚合的乙烯基-4,6-二氨基 - 1,3,5-三嗪（polyVDAT）纳米粒子。 可用于例如制造这种生物传感器的水性组合物包括polyVDAT纳米颗粒和水，其中polyVDAT纳米颗粒作为分散体存在于水中。 用于测定含有尿酸的体液样品中的分析物的方法包括将含有尿酸的体液样品施加到生物传感器，使得体液样品与含有聚合的乙烯基-4,6-二氨基的尿酸清除剂层接触 -1,3,5-三嗪（polyVDAT）纳米颗粒，并基于由生物传感器产生的电子信号确定分析物。